Five and 10 year follow-up of en bloc small pediatric kidneys in adult recipients

Increasing the donor pool using en bloc pediatric kidneys for transplant

“…In contrast, as already reported by others (19,21,23), we found that en bloc kidneys showed significantly better creatinine clearance that adult donor kidneys. The large number of nephrons in two transplanted kidneys contributes to this outcome.…”

“…Indeed, acceptable outcomes and good graft survival have been reported by others who used pediatric donor kidneys for transplant (23)(24)(25).…”

“…Given a growing discrepancy between the number of patients waiting for a kidney and the number of donors, more expanded organs could be used to help reduce the current kidney shortage. There are several ways of expanding the donor pool, including the increased use of kidneys from non-heart-beating donors (10), elderly donors (11), hepatitis C-positive kidneys for hepatitis C-positive recipients (12), and kidneys from pediatric donors (2)(3)(4)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). The use of kidneys from donors younger than 5 years of age is controversial and has been associated with higher complication rates arising from technical difficulties, graft thrombosis, early rejection, and hyperfiltration injury (17,18,21,25).…”

Update on En Bloc Renal Transplantation in Pediatric Recipients

“…While early reports of increased vascular complications with en bloc transplantation were discouraging [14][15][16][17], recent reports have shown more encouraging outcomes [4,[18][19][20], further confirmed by our study findings. This is likely due to increased experience and improvements in surgical techniques over time, which should help further reduce the skepticism in using young donor kidneys for transplantation.…”

Expanding the Organ Donor Pool: Using En Bloc Kidneys in Pediatric Recipients

“…While early reports of increased vascular complications with en bloc transplantation were discouraging [27][28][29][30], recent reports have shown more encouraging outcomes [5,11,26,31]. This is likely due to increased experience and improvements in surgical techniques over time, which should help further reduce the skepticism in using young donors for transplantation.…”