Five cases of intermittent left anterior hemiblock

Rosenbaum, Mauricio B.; Elizari, Marcelo V.; Levi, Raúl J.; Nau, Gerardo; Pisani, N.; Lázzari, Julio O.; Halpern, M. Susana

doi:10.1016/0002-9149(69)90044-7

Cited by 69 publications

(10 citation statements)

References 19 publications

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“…It seems likely that delayed anterior fascicular conduction due to myocardial fibrosis in the ventricular septum results in a leftward shift of the frontal QRS axis. 23 The same explanation may be applied to prolonged QRS duration as a marker for the detection of myocardial fibrosis because left anterior hemiblock could cause an increase in QRS duration of 10-20 ms. 24 Abnormal Q wave or fragmented QRS is considered to be a good marker of myocardial fibrosis in patients with CAD, 19,25 but neither was significantly associated with myocardial fibrosis in the present study. This may be explained by the difference in myocardial fibrosis between CAD and HCM patients.…”

contrasting

confidence: 43%

Notched QRS for the Assessment of Myocardial Fibrosis in Hypertrophic Cardiomyopathy

Kawasaki

Harimoto

Honda

et al. 2015

Circ J

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contrasting

confidence: 43%

Notched QRS for the Assessment of Myocardial Fibrosis in Hypertrophic Cardiomyopathy

Kawasaki

Harimoto

Honda

et al. 2015

Circ J

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“…18,20 The critical difference with LBBB (recently described in detail 21 ) is that the QRS scoring definition for LBBB requires the presence of mid-QRS notching and a minimum duration of 140 ms for men and 130 ms for women. To satisfy LAFB classification for QRS-scoring, we have used a minimum QRS duration of 100 ms because a block in the left anterior fascicle causes a prolongation of the QRS complex by 20 ms. 22 However, because women have shorter baseline QRS duration then men, 23 we propose a minimum QRS duration of 90 ms in women and 100 ms in men for defining LAFB. With regard to the lack of an upper boundary for QRS duration, LAFB may coexist with other QRS prolonging conduction defects such as LVH, a dilated ventricle or diffuse interstitial fibrosis leading to delayed intra-mural conduction.…”

Section: Performing Qrs Scoringmentioning

confidence: 99%

A detailed guide for quantification of myocardial scar with the Selvester QRS score in the presence of electrocardiogram confounders

Loring

Chelliah

Selvester

et al. 2011

Journal of Electrocardiology

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The Selvester QRS score translates subtle changes in ventricular depolarization measured by the electrocardiogram (ECG) into information about myocardial scar location and size. This estimation of scar has been shown to have a high degree of correlation with autopsy-measured myocardial infarct (MI) size. Additionally, multiple studies have demonstrated the value of the QRS score in post-MI patients to provide prognostic information. Recent studies have demonstrated that increasing QRS score is predictive of increased implantable defibrillator (ICD) shocks for ventricular tachycardia and fibrillation as well as decreased response to cardiac resynchronization therapy (CRT). While QRS scoring has never achieved widespread clinical use, increased interest in patient selection and risk-stratification techniques for ICDs and CRT has led to renewed interest in QRS scoring and its potential to identify which patients will benefit from device therapy. The QRS score criteria were updated in 2009 to expand their utility to a broader population by accounting for the different ventricular depolarization sequences in patients with bundle branch/fascicular blocks or ventricular hypertrophy. However, these changes also introduced additional complexity and nuance to the scoring procedure. This paper provides detailed instructions and examples on how to apply the QRS score criteria in the presence of confounding conduction types to facilitate understanding and enable development and application of automated QRS-scoring.

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“…reported that retrograde Purkinje activation allowed for more realistic simulation results in case of LBBB, they also found that to obtain typical patterns of left anterior fascicular block (LAFB) [91], it was necessary not only to cut off a part of the LV Purkinje network but also to disable reentry in the disconnected part [61]. Bacharova et al.…”

Section: Applications Of Computer Heart Modelsmentioning

confidence: 99%

Mathematical Modeling and Simulation of Ventricular Activation Sequences: Implications for Cardiac Resynchronization Therapy

Potse

2012

J. of Cardiovasc. Trans. Res.

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Next to clinical and experimental research, mathematical modeling plays a crucial role in medicine. Biomedical research takes place on many different levels, from molecules to the whole organism. Due to the complexity of biological systems, the interactions between components are often difficult or impossible to understand without the help of mathematical models. Mathematical models of cardiac electrophysiology have made a tremendous progress since the first numerical ECG simulations in the 1960s. This paper briefly reviews the development of this field and discusses some example cases where models have helped us forward, emphasizing applications that are relevant for the study of heart failure and cardiac resynchronization therapy.

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Five cases of intermittent left anterior hemiblock

Cited by 69 publications

References 19 publications

Notched QRS for the Assessment of Myocardial Fibrosis in Hypertrophic Cardiomyopathy

Notched QRS for the Assessment of Myocardial Fibrosis in Hypertrophic Cardiomyopathy

A detailed guide for quantification of myocardial scar with the Selvester QRS score in the presence of electrocardiogram confounders

Mathematical Modeling and Simulation of Ventricular Activation Sequences: Implications for Cardiac Resynchronization Therapy

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