Five-Fraction Radiosurgery Using a Biologically Equivalent Dose of a Single Fraction of 24 Gy for a 3-cm Parasagittal Para-Central Sulcus Brain Metastasis From Adenocarcinoma of the Cecum

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General radiotherapeutic management for >10 brain metastases (BMs) totaling >100 cm 3 , including multiple large lesions (>10-30 cm 3 ) in close proximity, demonstrated limited efficacy and/or safety. We describe a case of 12 BMs, summating 122.2 cm 3 , including a 39.6 cm 3 maximum lesion and adjacent ones. The patient had an 8.1-year treatment history for recurrent/metastatic breast cancer refractory to endocrine and chemotherapy. BMs were treated with conventional whole-brain radiotherapy (WBRT) with 30 Gy/10 fractions (fr), followed by an immediate stereotactic radiosurgery (SRS) boost with 27 Gy/5 fr (52-64% isodoses) which covers the gross tumor boundaries of selected eight lesions (total 118.4 cm 3 ). The SRS dose was defined to ensure the cumulative biologically effective dose (BED 10 ) of just ≥80 Gy while minimizing the risk of radiation injury. The SRS was performed using a CyberKnife (CK) robotic system (Accuray Incorporated, Sunnyvale, California, United States) with a variable-sized collimator (10-40 mm), for which en bloc consecutive irradiation, using 215 beams based on a comprehensively optimized single plan (path), was adopted. The treatment time per fraction was ≤45 min (mean 5.6 min per lesion). Afterward, BMs demonstrated remarkable regression over six months, causing the total residual visible lesions of 12.6 cm 3 (10.3%) at 11.4 months, despite the absence of obvious lesion shrinkage during the radiotherapy. WBRT, followed by an immediate 5-fr SRS boost with a total BED 10 of 80 Gy to large and/or culprit lesions, can be an efficacious and safe treatment option for multiple BMs, totaling >120 cm 3 . En bloc consecutive irradiation with a single path provides overwhelmingly more efficient delivery for treating multiple lesions using CK in terms of irradiation time and comprehensive reduction of normal brain dose compared to individual planning. Volumetric-modulated arc-based >10-fr SRS with simultaneously integrated reduced-dose WBRT may be an alternative to further enhance efficacy and safety.

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Case Presentationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Robotic Radiosurgical Boost After Whole-Brain Radiotherapy for 12 Brain Metastases: En Bloc Consecutive Irradiation With Comprehensively Optimized Single Plan for Eight Lesions Totaling 118 cc

Ohtakara,

Tanahashi,

Yamada

et al. 2023

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Fifteen-Fraction Radiosurgery Followed by Reduced-Dose Whole-Brain Irradiation With a Total Biologically Effective Dose of >90-100 Gy for a Locally Invasive Brain Metastasis From Lung Adenocarcinoma With a High Dissemination Potential

Ohtakara,

Ohka,

Tanahashi

et al. 2023

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A deep-seated, locally infiltrative 5.8-cm brain metastasis (BM) involving the ventricular wall and optic radiation is deemed unamenable for a safe total resection, while preventing tumor seeding. Meanwhile, radiotherapeutic management alone for such a BM close to the brainstem is also challenging.We describe such a BM (gross tumor volume [GTV] 40.3 cm 3 ) from lung adenocarcinoma (LAC), located in the left temporo-occipital lobes, with extensive invasion to the tentorium cerebelli and a high potential for dissemination. The BM was treated with 15-fraction(s) (fr) stereotactic radiosurgery (SRS) followed by whole-brain irradiation (WBI) at 27 Gy/15 fr with a 19-day interval. During the SRS, the solid component away from the tentorium showed obvious shrinkage. The cumulative biologically effective doses (BEDs) of the minimum and D 99% of the GTV were ≥92.3 Gy and ≥102.6 Gy, respectively, where the BED was based on the linear-quadratic formula at an alpha/beta ratio of 10 (BED 10 ). Despite a maximum response with nearly complete regression at 7.5 months, local tumor regrowth near the tentorial incisura became gradually apparent from 11.2 to 19.3 months. Salvage re-SRS with 53 Gy/10 fr specific to these lesions resulted in obvious regression at 5.8 months. However, radiation injury concomitant with triventriculomegaly progressed from 7.9 to 13.9 months, eventually leading to meningeal dissemination and patient mortality at 34.6 months. This case demonstrates that a BED 10 ≥90-100 Gy in 30 fr to the GTV boundary with a more than two-week interval without combined systemic therapy is insufficient for achieving complete local tumor eradication of a 40-cc LAC-BM. Shorter treatment duration with a steeper dose gradient outside and inside the GTV in the SRS or a volumetric modulated arc-based SRS combined with simultaneously integrated WBI may improve efficacy and safety.

Non-coplanar Arc-Involved Beam Arrangement With Sufficient Arc Rotations Is Suitable for Volumetric-Modulated Arc-Based Radiosurgery for Single Brain Metastasis

Ohtakara,

Suzuki

2024

Introduction In linac-based stereotactic radiosurgery (SRS) leveraging a multileaf collimator (MLC) for brain metastasis (BM), volumetric-modulated arcs (VMAs) enable the generation of a suitable dose distribution with efficient planning and delivery. However, the arc arrangement, including the number of arcs, allocation, and rotation ranges, varies substantially among devices and facilities. Some modalities allow coplanar arc(s) (CA(s)) or beam(s) alone, and some facilities only use them intentionally despite the availability of non-coplanar arcs (NCAs). The study was conducted to examine the significance of NCAs and the optimal arc rotation ranges in VMA-based SRS for a single BM. Materials and methods This was a planning study for the clinical scenario of a single BM, including 20 clinical cases with a gross tumor volume (GTV) of 0.72-44.30 cc. Three different arc arrangements were compared: 1) reciprocating double CA alone of each 360º rotation with different collimator angles of 0 and 90º, 2) one CA and two NCAs of each 120º rotation with the shortest beam path lengths to the irradiation isocenter (NCA_L), and 3) one CA of 360º rotation and two NCAs of each 180º rotation (NCA_F). The three arcs were allocated similarly to equally divide the cranial hemisphere with different collimator angles of 0, 45, and 90º. Three VMA-based SRS plans were generated for each GTV using a 5 mm leaf-width MLC with the identical optimization method that prioritized the steepness of dose gradient outside the GTV boundary without any constraints to the GTV internal dose. A prescribed dose was uniformly assigned to the GTV D V-0.01 cc , the minimum dose of GTV minus 0.01 cc. The GTV dose conformity, the steepness of dose gradients both outside and inside the GTV boundary, the degree of concentric lamellarity of the dose gradients, and the appropriateness of the dose attenuation margin outside the GTV boundary were evaluated using metrics appropriate for each. Results The arc arrangements including NCAs showed significantly steeper dose gradients both outside and inside the GTV boundary with smaller dose attenuation margins than the CAs alone, while NCAs showed no significant advantage on the GTV dose conformity. In the NCA-involved arc arrangements, the NCA_F was significantly superior to the NCA_L in terms of the GTV dose conformity, the steepness of dose gradient outside the GTV, the degree of concentric lamellarity of the dose gradients outside and inside the GTV boundary, and the appropriateness of dose attenuation margin. However, the NCA_F showed no significant advantage on the steepness of dose increase inside the GTV boundary over the NCA_L. The dose increase just inside the prescribed isodose surface to the GTV boundary was significantly steeper with the NCA_L than the NCA_F. Conclusions In VMA-based SRS for a single BM, an arc arrangement including NCAs is indispensable, and sufficient arc rotations are ...