Five miRNAs considered as molecular targets for predicting neuroglioma

Yang, Haiyuan; Wang, Ying

doi:10.1007/s13277-015-3898-9

Cited by 21 publications

(19 citation statements)

References 28 publications

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“…Consistent with our expression results, a previous study by Xu and colleagues also found the decreased miR-1298 expression in NSCLC by a bioinformatics analysis [14]. In addition to NSCLC, the reduced miR-1298 expression has also been identified in patients with gastric cancer [24] and neuroglioma [25], indicating the tumor suppressor role of miR-1298 in tumorigenesis.…”

Section: Discussionsupporting

confidence: 92%

MicroRNA-1298 is downregulated in non-small cell lung cancer and suppresses tumor progression in tumor cells

Wang

et al. 2019

Diagn Pathol

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Background: MicroRNAs (miRNAs) have been reported to serve pivotal roles in tumorigenesis. This study sough to assess the expression and clinical significance of microRNA-1298 (miR-1298) in patients with non-small cell lung cancer (NSCLC), and explore the functional role of miR-1298 in tumorigenesis. Methods: One hundred and twenty-one NSCLC patients were recruited in this study. The expression of miR-1298 was estimated using quantitative real-time PCR. Kaplan-Meier survival curves and Cox regression analysis were used to evaluate the prognostic value of miR-1298. Gain-and loss-of-function experiments were preformed to explore the biological function of miR-1298 in NSCLC cells. Results: Expression levels of miR-1298 were downregulated in NSCLC tissues and cells compared with the corresponding normal controls. The decreased expression of miR-1298 was associated with patients' lymph node metastasis and TNM stage. The low expression of miR-1298 predicted poor overall survival and served as an independent prognostic indicator in NSCLC patients. According to the cell experiments, NSCLC cell proliferation, migration and invasion were inhibited by the overexpression of miR-1298. Conclusion: All the data indicated that the downregulation of miR-1298 predicts poor prognosis of NSCLC, and the overexpression of miR-1298 in NSCLC cells leads to inhibited tumorigenesis. The aberrant miR-1298 may serve as a novel biomarker and therapeutic target in NSCLC.

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Section: Discussionsupporting

confidence: 92%

MicroRNA-1298 is downregulated in non-small cell lung cancer and suppresses tumor progression in tumor cells

Wang

et al. 2019

Diagn Pathol

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“… 22 MiR-1911-3p has been reported to have a correlation with neuroglioma. 23 In addition to the two miRNAs, most identified DE-miRNAs have been confirmed to be associated with tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

Identification of chemoresistance-associated miRNAs in breast cancer

Lou¹,

Liu²,

Ding³

et al. 2018

CMAR

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BackgroundNeoadjuvant chemotherapy (NAC) is an effective therapeutic regimen for patients with breast cancer. However, some individuals cannot benefit from NAC because of drug resistance. To date, valid strategies about enhancing sensitivity of breast cancer to NAC are still scarce. miRNAs have been reported to proverbially be involved in the onset and development of malignancies including drug resistance.MethodsGSE73736 was downloaded from the GEO database. Student’s t-test was conducted to acquire differentially expressed-miRNAs (DE-miRNAs). Potential target genes of DE-miRNAs were predicted by miRTarBase. Gene Ontology annotation and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses for these target genes were performed by database for annotation, visualization, and integrated discovery. Protein–protein interaction network was constructed by STRING database and visualized through Cytoscape software. The hub target gene-miRNA network was also established by Cytoscape software. Next, the expression of potential functional miRNAs in breast cancer cell lines and tissues was determined. Finally, the roles of miR-3617-3p, miR-3136-3p, and miR-520b in modulating breast cancer chemoresistance were further examined.ResultsA total of 123 DE-miRNAs were identified, including 60 upregulated miRNAs and 63 downregulated miRNAs in the chemoresistant breast cancer group when compared with the chemosensitive group. Six hundred and seventeen and 1,146 potential target genes for the top 10 most upregulated and downregulated miRNAs were predicted, respectively. Enrichment analyses revealed that these target genes were enriched in some cancer-associated or chemo-resistance-associated pathways, such as MAPK signaling pathway, wnt signaling pathway, and p53 signaling pathway. MAPK1 and PRDM10 were identified as hub genes in the protein–protein interaction network. The top 25 hub genes were potentially regulated by 16 DE-miRNAs, among which miR-3617-3p and miR-3136-3p were commonly upregulated, whereas miR-520b was downregulated in two chemoresistant breast cancer cells compared with chemosensitive cell. By analyzing TCGA data, we found that expression of miR-3136-3p and miR-520b was increased and decreased in breast cancer tissues, respectively. Moreover, functional experiments demonstrated that miR-3136-3p and miR-3617-3p could reduce chemosensitivity of breast cancer, whereas miR-520b could reverse chemoresistance.ConclusionThe present study, based on bioinformatics analysis and experimental validation, brings to light novel mechanisms of breast cancer NAC resistance.

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“…Recently, abnormal expression of miR‐455 was reported in several human diseases (Ji et al, ; Zhang et al, ). Expression of miR‐455 is elevated in glioblastoma multiforme cells and osteoarthritis (Ujifuku et al, ; Swingler et al, ), but reduced in gastric cancer and neuroglioma (Dong et al, ; Yang and Wang, ). Importantly, upregulation of miR‐455 expression has been shown to suppress cell growth and metastases in melanoma and colorectal cancer (Chai et al, ; Shoshan et al, ).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‐455 suppresses non‐small cell lung cancer through targeting ZEB1

Chen

Tang

et al. 2016

Cell Biology International

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MicroRNA-455 (miRNA-455), which is downregulated in human cancer, potently mediates the multiple steps of carcinogenesis. However, the role of miR-455 in non-small cell lung cancer (NSCLC) carcinogenesis remains unclear. In present study, we determined the mature miRNA-455 expression in NSCLC tissues and cells by real-time PCR. Follow-up studies examined the effects of a miR-455 mimic (gain of function) on cell proliferation, migration, and invasion. Our data indicate that miR-455 was significantly down-regulated in NSCLC cell lines and tissues. In functional assays, overexpression of miR-455 suppressed the proliferation, migration, and invasion of NSCLC cell lines. Data from reporter assays showed that miR-455 directly binds to 3'UTR of ZEB1 and suppresses the endogenous level of ZEB1 protein expression. Furthermore, overexpression of ZEB1 reverses miR-455-suppressed malignant phenotype of NSCLC cells. Moreover, we found that upregulation of ZEB1 expression is inversely associated with miR-455 expression in NSCLC tissues. Taken together, miR-455 as an anti-oncogene in non-small cell lung cancer through up-regulation of ZEB1 and serve as a potential therapeutic target in NSCLC.

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Five miRNAs considered as molecular targets for predicting neuroglioma

Cited by 21 publications

References 28 publications

MicroRNA-1298 is downregulated in non-small cell lung cancer and suppresses tumor progression in tumor cells

MicroRNA-1298 is downregulated in non-small cell lung cancer and suppresses tumor progression in tumor cells

Identification of chemoresistance-associated miRNAs in breast cancer

MicroRNA‐455 suppresses non‐small cell lung cancer through targeting ZEB1

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