Five New Nortropane Alkaloids and Six New Amino Acids from the Fruit of Morus alba LINNE Growing in Turkey.

Kusano, Genjirou; Orihara, Shiho; Tsukamoto, Daisuke; Shibano, Makio; Coşkun, Maksut; Güvenç, Ayşegül; Erdurak, Ceyda Sibel

doi:10.1248/cpb.50.185

Cited by 66 publications

(52 citation statements)

References 13 publications

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“…In addition, cyanidin glucose isolated from M. alba inhibited cerebral ischemic condition caused by oxygen-glucose deprivation in PC12 cells (Kang et al, 2006). A number of prenylated flavonoids, stilbenes, benzofurans, terpenes, alkaloids, and other phenolic compounds were previously reported as chemical constituents of this tree Ueda et al, 1982Ueda et al, , 1984Hano et al, , 1989aHano et al, , 1989bQiu et al, 1996;Asano et al, 2001;Kusano et al, 2002;Lee et al, 2002;Zhang et al, 2009). However, to date, there are a few reports on the chemical constituent of Morus species possessing neuroprotective activity.…”

Section: Introductionmentioning

confidence: 98%

Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells

et al. 2011

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Three known 2-arylbenzofurans, moracin P (1), moracin O (2) and mulberrofuran Q (3) were isolated from the MeOH extract of the Mori Cortex Radicis. These compounds 1-3 enhanced cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells, which was measured by MTT reduction assay. (EC(50) values of 10.4, 12.6, and 15.9 μM, respectively). In addition, the compounds 1-3 were examined for their inhibitory effect on OGD-induced ROS production by FACS analysis. We observed these compounds reduced ROS production in OGD-induced cell death (IC(50) values of 1.9, 0.3 and 12.1 μM, respectively). Consequently, reactive oxygen species (ROS) were overexpressed in OGD-induced cells and all three compounds reduced ROS induced by OGD in dosedependent manner. Taken together, compounds 1-3 might protect neuronal cell death against the oxidative stress induced by OGD, though further studies in vitro and in vivo models are necessary.

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Section: Introductionmentioning

confidence: 98%

Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells

et al. 2011

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“…Wild figs (F. carica and F. palmata) are rich in minerals and sugars, predominantly fructose and glucose. Their fruits are known to be a rich source of minerals, phenolics, anthocyanins and flavonoids [9,10]. The chemical composition and nutritional status of plant edibles may be influenced by the physiological and environmental factors of the area, such as soil chemistry and climatic conditions [11].…”

Section: Introductionmentioning

confidence: 99%

Nutrient and mineral assessment of edible wild fig and mulberry fruits

Sadia

Ahmad

Sultana

et al. 2014

Fruits

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Nutrient and mineral assessment of edible wild fig and mulberry fruits.Abstract -Introduction. Edible wild plants are nature's gift to mankind. Considering the growing need to identify alternative bio-nutritional sources, some underutilized species of figs (Ficus carica L., F. palmata Forssk., F. racemosa L.) and mulberries (Morus alba L., M. nigra L, M. laevigata Wall.) of the family Moraceae were evaluated as wild edible fruits to study their nutritive and mineral composition in order to prioritize their edibility for indigenous people. Materials and methods. The major proximal components (moisture, ash, lipids, proteins, fibers and carbohydrates) were determined by standard AOAC methods. The concentration of various minerals (K, Ca, Mg and Na) and trace elements (Fe, Mn, Zn, Cu and Ni) Résumé -Introduction. Les plantes sauvages comestibles sont un don que fait la nature à l'humanité. Considérant le besoin croissant d'identifier de nouvelles sources de bio-nutrition, certaines espèces sous-utilisées de figuiers (Ficus carica L., F. palmata Forssk., F. racemosa L.) et de mûriers (Morus alba L., M. nigra L, M. laevigata Wall.) de la famille des Moraceae ont été évaluées en tant que fruits sauvages comestibles pour étudier leur composition nutritive et minérale afin de prioriser leur consommation auprès des populations autochtones. Matériel et méthodes. La composition globale des fruits étudiés (humidité, cendres, lipides, protéines, fibres et glucides) a été déterminée par utilisation de méthodes AOAC standards. La concentration en divers miné-raux (K, Ca, Mg et Na) et en oligo-éléments (Fe, Mn, Zn, Cu et Ni) a été déterminée en utilisant un spectrophotomètre d'absorption atomique. Résultats. Nos résultats ont révélé une gamme de teneurs en humidité de 17,82-80,37 g⋅100 g -1 (poids frais) pour F. carica-M. laviegata ; en protéines, de 6,31-13,50 g⋅100 g -1 (poids sec) pour F. glomerata-M. alba ; en graisses brutes, de 1,02-2,71 g⋅100 g -1 pour F. palmate-F. glomerata ; en glucides, de 69,47-75,58 g⋅100 g -1 pour M. alba-M. nigra ; en fibres, de 7,63-17,81 g⋅100 g -1 pour M. laviegata-F. palmate, respectivement. Une valeur énergétique significativement élevée a été calculée pour M. laviegata (367,7 kcal⋅100 g -1 ). En outre, des quantités non négligeables d'éléments essentiels ont été trouvées chez toutes les espèces étudiées. Les plus hauts niveaux de N [(0,24 ± 0,07)

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“…A piper dine alkaloid and some glycoproteins were isolated from the bark and leaves, which had antidiabetic effects (Kusano et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Phytochemical reports on M. alba L. indicates that the plant contains flavonoids, tannins, triterpenes, anthocyanins, anthroquinones, phytosterols, sitosterols, benzofuran derivatives, morusimic acid, oleanolic acid, alkoloids, steroids, saponins and phenolic compounds (El-Beshbishy et al, 2005;Kusano et al, 2002). A survey of the literature on M. alba revealed only a few pharmacological reports on the plant.…”

Section: Introductionmentioning

confidence: 99%

EXPLORATION OF HEALING PROMOTING POTENTIALS OF LEAVES OF <i>MORUS ALBA</i> L. IN ALBINO RATS

Kaushik¹

2013

American Journal of Pharmacology and Toxicology

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To establish the wound healing activity of aqueous and ethanolic extract of roots of Morus alba. Two models were performed to evaluate the wound healing activity i.e., Incision and Excision model. In incision model the parameter which was carried out was breaking strength of wounded skin. In excision model percentage wound contraction and period of epithelialization was established for both the extracts. Reference standard drug was Aloe vera ointment for comparison with other groups. From the observation in both the models, Aq. extract of Morus alba was found to have greater wound healing activity in terms of breaking strength in incision model and percentage wound contraction, period of epithelialization was highest in excision model compared with other groups. In conclusion, our findings suggest that aq. extract of Morus alba possess better healing ability than the ethanolic extract.

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Five New Nortropane Alkaloids and Six New Amino Acids from the Fruit of Morus alba LINNE Growing in Turkey.

Cited by 66 publications

References 13 publications

Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells

Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells

Nutrient and mineral assessment of edible wild fig and mulberry fruits

EXPLORATION OF HEALING PROMOTING POTENTIALS OF LEAVES OF <i>MORUS ALBA</i> L. IN ALBINO RATS

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