Five preventable causes of kidney graft loss in the 1990s: A single-center analysis1

Abstract

This study identified the five major causes of kidney graft loss in the 1990s. Different interventions are required to decrease loss from each of these causes. Future research needs to be directed at such interventions.

Mutação G20210A no gene da protrombina, fator V de Leiden e anticorpos anticardiolipina não influenciam a sobrevida do enxerto renal após o transplante

“…[33][34][35][36] Estas observações sugerem que a identificação de pacientes com risco aumentado de complicações trombóticas e a utilização de anticoagulação profilática podem beneficiar um número significativo de receptores de transplante renal. Contudo, a realização rotineira de testes de identificação da condição de trombofilia e a prescrição de anticoagulação profilática após o transplante renal são ainda assuntos controversos.…”

Inhibition of Prolyl-4-Hydroxylase Ameliorates Chronic Rejection of Mouse Kidney Allografts

“…effective immunosuppression, CAN continues to be the major cause of late graft loss (26). Treatment with ACE inhibitors or angiotensin receptor antagonists have improved renal function in rodent models of CAN (27,28), and have been used in clinical settings with modest improvement (29).…”

Evaluation of Kidney Function and Structure in Potential Living Kidney Donors: Implications for the Donor and Recipient

“…Chronic allograft nephropathy is a common cause of kidney allograft failure [52], and histologically it is characterized by changes that include interstitial fibrosis and tubular atrophy [53]. These changes are associated with reduced renal function and graft survival, and are found in mild forms in protocol biopsies of living donor recipients.…”