Five spectrophotometric methods for simultaneous determination of Amlodipine besylate and celecoxib in presence of its toxic impurity

Sharkawi, Marco M Z; Mohamed, Norhan R.; El‐Saadi, Mohammed T.; Amin, Noha H.

doi:10.1016/j.saa.2021.120137

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…1), classified as a COX-2 selective NSAID, is commonly prescribed for patients with osteoarthritis and rheumatoid arthritis, being more advantageous than other NSAIDs because of its reduced gastrointestinal side effects [8]. Several analytical methods are reported in the literature for celecoxib solely or in combinations such as HPLC [9][10][11][12], spectrophotometric methods [13][14][15], TLC [16][17][18] in addition to electrochemical methods [19][20][21]. 1), an analgesic medication with dual monoaminergic reuptake inhibitory and opioid receptor agonist activities, is used for neuropathic pain, osteoarthritic pain as well as low back and rheumatoid arthritis [22].…”

Section: Introductionmentioning

confidence: 99%

First derivative synchronous spectrofluorimetric method for the simultaneous determination of tramadol and celecoxib in their dosage forms and human plasma

Ramadan,

Abdel Salam,

Hadad

et al. 2024

Luminescence

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One of the most common features of many different clinical conditions is pain; hence, there is a crucial need for eliminating or reducing it to a tolerable level to retrieve physical, psychological and social functioning. A first derivative synchronous spectrofluorimetry technique is proposed for the simultaneous determination of celecoxib and tramadol HCl, a recent coformulation authorized for treating acute pain in adults. The method includes using synchronous spectrofluorimetry at ∆λ = 80 nm where tramadol HCl was determined using first derivative technique at λ = 230.2 nm, while celecoxib was determined at λ = 288.24 nm. The proposed method was successfully applied to their co‐formulated dosage forms in addition to spiked human plasma and validated in agreement with the guidelines of the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH). The linear ranges were found to be 0.50–5.0 and 0.15–0.50, the limits of detection to be 0.088 and 0.011 and the limits of quantification to be 0.266 and 0.032 μg/ml for celecoxib and tramadol, respectively. Statistical analysis revealed no significant difference when compared with previously reported methods as evidenced by the values of the variance ratio F‐test and Student t‐test. The proposed method was successfully applied to commercial dosage forms and spiked human samples. Moreover, the greenness of the proposed method was investigated based on the analytical eco‐scale approach, with the results showing an excellent green scale with a score of 95.

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Section: Introductionmentioning

confidence: 99%

First derivative synchronous spectrofluorimetric method for the simultaneous determination of tramadol and celecoxib in their dosage forms and human plasma

Ramadan,

Abdel Salam,

Hadad

et al. 2024

Luminescence

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show abstract

“…Scientists have reported different analytical methods for the quantification of the above fixed dose combination in synthetic mixtures, pharmaceutical formulation and biological fluids. For instance, UV [8][9][10][11][12] , TLC 13 , HPLC [14][15][16] and LC-MS/MS 17 methods have been developed. Overall, 10 studies have been reported for the estimation of Celecoxib and Amlodipine simultaneously among which only two papers had described quantification of the two drugs in biological samples using HPLC and LC-MS/MS.…”

Section: Introductionmentioning

confidence: 99%

Novel Validated LC-MS/MS Method For Simultaneous Estimation of Celecoxib and Amlodipine in Rat Plasma and Its Application to A Pharmacokinetic Study

Eswarudu¹

2022

Journal of Pharmaceutical Negative Results

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The combination of celecoxib (CLX) and Amlodipine (AMD) was approved for hypertensive patients with osteoarthritis by US-FDA. Hence, a potential analytical method that can simultaneously quantify these two drugs is required. In view of this, a novel and fully validated liquid chromatography-electrospray ionization-tandem mass spectrometric (LC-ESI-MS/MS) method has been established for the quantification of CLX and AMD in rat plasma simultaneously. protein precipitation extraction technique was employed for the extraction of analytes and their deuterated analogues from rat plasma quantitatively. The analytes were separated using the mobile phase comprising of acetonitrile–water with 0.1% formic acid buffer (70:30 v/v) and a flow-rate of 1.0 mL/min and 10 min run time on Agilent SB-C18 analytical column. The multiple reaction monitoring transitions, m/z 504.7→98.1 for CLX, 492.8→129.3 for AMD; 385.6→102.8 for CLX-D4 and 496.8.5→412.3 for AMD-D4 were utilized for the analysis in order to attain high selectivity. The method showed good sensitivity and linearity in the range of the concentration 20–800 ng/mL for CLX and 0.25–10 ng/mL for AMD respectively. Moreover, the method also displayed decent accuracy (87.9-100.27% and 99.28-103.26%) for CLX and AMD and precision according to US-FDA guidelines. The precision values for inter- and intra-day were between 1.92.02-7.085% and 0.083-3.43% and for CLX and AMD respectively. Further, the results of the pharmacokinetic parameters including Cmax, tmax, AUC0-t, AUC0-∞ and t1/2 values of drugs indicated that the developed method is valuable for the successful quantification of the analytes in rat plasma. The developed method is significant and is useful for simultaneous quantification of CLX and AMD.

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Green synthesis of silver nanoparticle for estimation of dextrose in the presence of cysteine, methionine and urea by derivative method

Ismail,

Amjad,

Reshak

et al. 2024

Microchemical Journal

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Five spectrophotometric methods for simultaneous determination of Amlodipine besylate and celecoxib in presence of its toxic impurity

Cited by 7 publications

References 20 publications

First derivative synchronous spectrofluorimetric method for the simultaneous determination of tramadol and celecoxib in their dosage forms and human plasma

First derivative synchronous spectrofluorimetric method for the simultaneous determination of tramadol and celecoxib in their dosage forms and human plasma

Novel Validated LC-MS/MS Method For Simultaneous Estimation of Celecoxib and Amlodipine in Rat Plasma and Its Application to A Pharmacokinetic Study

Green synthesis of silver nanoparticle for estimation of dextrose in the presence of cysteine, methionine and urea by derivative method

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