Five Trk Receptors in the Zebrafish

Martin, Stella C.; Marazzi, Giovanna; Sandell, Julie H.; Heinrich, G.

doi:10.1006/dbio.1995.1184

Cited by 81 publications

(95 citation statements)

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“…1C,D). Additionally, neither subpopulation overlapped with the larger trkA (nerve growth factor receptor)-expressing population (17.38±1.66 cells/ganglion) (Knaut et al, 2005;Liu and Ma, 2011;Martin et al, 1995) (Fig. 1D, supplementary material Fig.…”

Section: Subtype-specific Gene Expression Of Trigeminal Sensory Neuronsmentioning

confidence: 98%

Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons

et al. 2012

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SUMMARYHow neurons connect to form functional circuits is central to the understanding of the development and function of the nervous system. In the somatosensory system, perception of sensory stimuli to the head requires specific connections between trigeminal sensory neurons and their many target areas in the central nervous system. Different trigeminal subtypes have specialized functions and downstream circuits, but it has remained unclear how subtype-specific axonal projection patterns are formed. Using zebrafish as a model system, we followed the development of two trigeminal sensory neuron subtypes: one that expresses trpa1b, a nociceptive channel important for sensing environmental chemicals; and a distinct subtype labeled by an islet1 reporter (Isl1SS). We found that Trpa1b and Isl1SS neurons have overall similar axon trajectories but different branching morphologies and distributions of presynaptic sites. Compared with Trpa1b neurons, Isl1SS neurons display reduced branch growth and synaptogenesis at the hindbrain-spinal cord junction. The subtype-specific morphogenesis of Isl1SS neurons depends on the guidance receptor Robo2. robo2 is preferentially expressed in the Isl1SS subset and inhibits branch growth and synaptogenesis. In the absence of Robo2, Isl1SS afferents acquire many of the characteristics of Trpa1b afferents. These results reveal that subtypespecific activity of Robo2 regulates subcircuit morphogenesis in the trigeminal sensory system.

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Section: Subtype-specific Gene Expression Of Trigeminal Sensory Neuronsmentioning

confidence: 98%

Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons

et al. 2012

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“…Bony fish orthologs of NGF, BDNF, NT-3 and NT-4/5 as well as of TrkA, TrkB and TrkC are known [Hallböök et al, 1991;Götz et al, 1994;Martin et al, 1995;Dethleffsen et al, 2003]. A complete set of the 'core' four neurotrophins were retrieved in two pufferfish (Takifugu rubripes and Tetraodon nigroviridis) and the zebrafish (Danio rerio) genome assemblies.…”

Section: Neurotrophins In Bony and Cartilaginous Fishesmentioning

confidence: 99%

“…NT-6/7 as well as fish NGF bind and activate TrkA and their expression suggests that subfunctionalization and to some degree neofunctionalization have occurred after the duplication [Dethleffsen et al, 2003]. Two paralogs of TrkB and of TrkC receptor genes have been identified in both zebrafish [Martin et al, 1995] and pufferfish genomes (TrkB1, TrkB2, TrkC1 and TrkC2) [BenitoGutierrez et al, 2006]. Phylogenetic analysis unambiguously shows that fish NT-6/7 and NGF evolved from the same ancestor and that those two genes, the fish TrkB1 -TrkB2 and TrkC1 -TrkC2 paralogs emerged from 'bony fish-specific' duplications.…”

Section: Neurotrophins In Bony and Cartilaginous Fishesmentioning

confidence: 99%

Formation and Evolution of the Chordate Neurotrophin and Trk Receptor Genes

et al. 2006

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Neurotrophins are structurally related neurotrophic polypeptide factors that regulate neuronal differentiation and are essential for neuronal survival, neurite growth and plasticity. It has until very recently been thought that the neurotrophin system appeared with the vertebrate species, but identification of a cephalochordate neurotrophin receptor (Trk), and more recently neurotrophin sequences in several genomes of deuterostome invertebrates, show that the system already existed at the stem of the deuterostome group. Comparative genomics supports the hypothesis that two whole genome duplications produced many of the vertebrate gene families, among those the neurotrophin and Trk families. It remains to be proven to what extent the whole genome duplications have driven macroevolutionary change, but it appears certain that the formation of the multi-gene copy neurotrophin and Trk receptor families at the stem of vertebrates has provided a foundation from which the various functions and pleiotropic effects produced by each of the four extant neurotrophins have evolved.

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“…With regard to teleost fish, BDNF expression has been confirmed in the brain of the southern platyfish [Götz et al, 1992], in the developing zebrafish brain and retina [Hashimoto and Heinrich, 1997;Lum et al, 2001], and in the tench retina [Caminos et al, 1999]. Five neurotrophin receptors have been described in zebrafish [Martin et al, 1995], two of which have been reported to be isoforms of the Trk B receptor and their mRNA is widely distributed throughout the brain and spinal cord of larval zebrafish [Martin et al, 1995]. Hannestad et al [2000] observed immunoreactivity for Trk B in the adenohypophysis, striatum and retina during development of Dicentrarchus .…”

Section: Introductionmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor mRNA Expression in the Brain of the Teleost Fish, <i>Anguilla anguilla,</i> the European Eel

et al. 2009

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The spatial expression pattern of Brain-Derived Neurotrophic Factor (BDNF) mRNA in the brain of the European eel (Anguilla anguilla) was determined using non-radioactive in situ hybridization, and mapped and compared to that of other vertebrates. Riboprobes were prepared based on a partial cDNA coding sequence for A. anguilla BDNF that was amplified using degenerate primers, cloned and sequenced. As in other animal groups, in the eel, BDNF mRNA expression was seen in the telencephalon, hypothalamus, tectum, many primary and secondary sensory centers, and cranial motor nuclei. However, in contrast to mammals, BDNF mRNA expression was observed in some brain stem nuclei, such as the reticular formation, that contain cell bodies of neurons that project down the spinal cord. We suggest that these differences might relate to the continual growth of teleost fish.

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Five Trk Receptors in the Zebrafish

Cited by 81 publications

References 0 publications

Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons

Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons

Formation and Evolution of the Chordate Neurotrophin and Trk Receptor Genes

Brain-Derived Neurotrophic Factor mRNA Expression in the Brain of the Teleost Fish, <i>Anguilla anguilla,</i> the European Eel

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