Five undescribed aryltetralin lignans with cytotoxic activities from the fruits of Cleistanthus eberhardtii

Nguyen, Lam Hong; Nguyen, Thi Hue; Tran, Viet Hung; Litaudon, Marc; Nguyen, Van Thanh; Doan, Thi Mai Huong; Pham, Van Cuong

doi:10.1016/j.fitote.2024.105826

Fitoterapia

2024

DOI: 10.1016/j.fitote.2024.105826

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Five undescribed aryltetralin lignans with cytotoxic activities from the fruits of Cleistanthus eberhardtii

Lam Hong Nguyen,

Thi Hue Nguyen,

Viet Hung Tran

et al.

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2024

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Cited by 2 publications

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New Cytotoxic Sesquiterpene Lactones from the Leaves of Tithonia Diversifolia and their Apoptosis Effect Evaluation in KB Cancer Cells

Tran,

Do,

Phi

et al. 2024

Chemistry & Biodiversity

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From the leaves of Tithonia diversifolia, nine sesquiterpenoids (1—9), including two new ones (1, 2) were isolated and structurally determined. Their chemical structures were elucidated by extensive analyses of HRESIMS and NMR spectral data, as well as comparison with the literature. All of the isolated compounds (except compounds 7, 8, 9) significantly exhibited cytotoxic activity against four human cancer cell lines (KB, HepG2, A549 and MCF7), with IC50 values ranging from 0.29‐17.0 µM, which was in the same range as the positive control ellipticine or even lower. Further, the apoptosis induction of two new compounds 1 and 2 were also investigated and reported. While compound 2 did not induce cell apoptosis in KB cells at test concentrations, compound 1 was found to possess anti‐proliferative activity through concentration‐dependently inducing cell cycle arrest at S phase, morphological changes, activation of caspase 3, and an increase in the early‐stage apoptosis of KB cells at a concentration of 7.26 µM.

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New Cytotoxic Sesquiterpene Lactones from the Leaves of Tithonia Diversifolia and their Apoptosis Effect Evaluation in KB Cancer Cells

Tran,

Do,

Phi

et al. 2024

Chemistry & Biodiversity

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show abstract

Acylphloroglucinol derivatives from the aerial parts of Syzygium borneense and their cytotoxic activities

Nguyen,

Do,

Litaudon

et al. 2024

Phytochemistry Letters

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Five undescribed aryltetralin lignans with cytotoxic activities from the fruits of Cleistanthus eberhardtii

Cited by 2 publications

References 19 publications

New Cytotoxic Sesquiterpene Lactones from the Leaves of Tithonia Diversifolia and their Apoptosis Effect Evaluation in KB Cancer Cells

New Cytotoxic Sesquiterpene Lactones from the Leaves of Tithonia Diversifolia and their Apoptosis Effect Evaluation in KB Cancer Cells

Acylphloroglucinol derivatives from the aerial parts of Syzygium borneense and their cytotoxic activities

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