Five-Year Outcomes from 3 Prospective Trials of Image-Guided Proton Therapy for Prostate Cancer

Mendenhall, Nancy P.; Hoppe, Bradford S.; Nichols, R.C.; Mendenhall, William M.; Morris, Christopher G.; Li, Zuofeng; Su, Zhong; Williams, Christopher R.; Costa, Joseph; Henderson, Randal H.

doi:10.1016/j.ijrobp.2013.11.007

Cited by 101 publications

(93 citation statements)

References 33 publications

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“…The University of Florida reported 5-year patientreported outcomes from three prospective trials of image-guided proton-only therapy 76 . Prospectively collected quality-of-life scores during the first 2 years were similar in 1243 men after pbt and 204 men after imrt 77 .…”

Section: Prostatementioning

confidence: 99%

Recommendations for the Referral of Patients for Proton-Beam Therapy, an Alberta Health Services Report: A Model for Canada?

et al. 2014

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able and willing to travel abroad to a proton facility. Commonly accepted indications for referral include chordoma and chondrosarcoma, intraocular melanoma, and solid tumours in children and adolescents who have the greatest risk for long-term sequelae. Current data do not provide sufficient evidence to recommend routine referral of patients with most head-and-neck, breast, lung, gastrointestinal tract, and pelvic cancers, including prostate cancer. It is recommended that all referrals be considered by a multidisciplinary team to select appropriate cases.

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Section: Prostatementioning

confidence: 99%

Recommendations for the Referral of Patients for Proton-Beam Therapy, an Alberta Health Services Report: A Model for Canada?

et al. 2014

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“…With the passing of time after treatment, complication rates rise after 5 years at the G2 level; 21-31% in the urinary tract and 10-18% in the rectum [88,95,96,[102][103][104][105][106][107]. It should be emphasised that late complications are more common for those patients where attempts at dose escalation were made using proton radiotherapy alone or in the booster form after conventional radiation therapy [103,107,109]. A randomised phase III study by Shipley et al indeed confirmed this, where the efficacy of 75.6 Gy (photon radiotherapy with proton "boost") vs 67.2 Gy (photon radiotherapy) was compared.…”

Section: Prostate Cancer (Pc)mentioning

confidence: 99%

“…Proton radiotherapy is also used as a stand-alone radiotherapy so that doses can be increased to 74-78 Gy RBE by conventional fractionation or in hypofractionation dose regimens of 35-60 Gy RBE in 5-20 fractions [99,104,106,107].…”

Section: Prostate Cancer (Pc)mentioning

confidence: 99%

Proton radiotherapy for treating the most common carcinomas

Sas-Korczyńska

Jakubowicz²,

Reinfuss³

2017

Nowotwory. Journal of Oncology

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A literature review is presented on proton radiotherapy when used for treating the most common carcinoma types such as cancer of the lung, breast and prostate. This is based on analytic parameters of dosimetry and clinical outcomes (efficacy and toxicity), along with studies on cost-effectiveness as compared to those achieved by conventional photon radiotherapy. NOWOTWORY J Oncol 2016; 66, 5: 396-402

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“…Mendenhall et all have analyzed the clinical outcomes of 3 prospective trials reporting 99%, 99% and 76% 5-year rates of biochemical control and freedom of disease progression for low, intermediate and high risk patients respectively [21]. On the other hand, some authors have analyzed gastrointestinal effects of proton therapy showing lower rates of rectal toxicity (14.5% grade 2 and 0.9% grade 3 or more) when compared with conventional radiotherapy or IMRT [22].…”

Section: Dose Escalationmentioning

confidence: 99%