Five-Year Trends in Multifocal Electroretinogram for Patients With Birdshot Chorioretinopathy

Mailhac, Adriane; Labarère, José; Aptel, Florent; Berthemy, Sylvie; Bouillet, Laurence; Chiquet, C.

doi:10.1016/j.ajo.2018.11.022

Cited by 11 publications

(9 citation statements)

References 46 publications

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“…More specifically, an increased 30 Hz implicit time seems to correlate with retinal vasculitis and to reflect ongoing disease activity. [57][58][59][60][61][62][63][64][65][66] We could not confirm this finding, as the 30 Hz implicit time did not reach significance after 1 year of treatment, neither did any other ERG parameter. Furthermore, ERG is technically demanding and very uncomfortable to the patient.…”

Section: Clinical Sciencementioning

confidence: 78%

Efficacy and safety of abatacept to treat active birdshot uveitis: a prospective open label interventional proof-of-concept trial

Schauwvlieghe

Calster

Herbort³

et al. 2022

Br J Ophthalmol

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Background/aimsBirdshot uveitis (BU) is a chronic autoimmune posterior uveitis, mostly affecting middle-aged Caucasians. There is a strong association with HLA-A29 and T-cell activation. Safety and efficacy of abatacept, an inhibitor of T-cell costimulation, is tested in active BU.MethodsFifteen patients with active BU were treated with monotherapy of weekly subcutaneous injections of abatacept 125 mg/mL. Time-to-treatment failure was evaluated as a primary outcome. The secondary objective was to evaluate the utility of different outcome measures to monitor disease activity. Safety was evaluated by adverse event reporting and serial blood analyses.ResultsAt the year-1 endpoint, there was significant improvement in vitreous haze grade (p=0.0014), central choroidal thickness (CCT) (p=0.0011), Fluorescein Angiography (FA) Score (p=0.0014), Indocyanine Green Angiography (ICGA) Score (p<0.001) and total dual FA-ICGA Score (p<0.001). Best corrected visual acuity (BCVA) (p=0.8354) and central retinal thickness (CRT) (p=0.3549) did not change significantly. There were no serious adverse events reported. In total, 4 out of 15 patients left the trial during year 1 of whom 2 experienced treatment failure.ConclusionsAbatacept is very efficacious to treat both retinal vasculitis and choroiditis in patients with BU and is well tolerated. BCVA and CRT are inadequate to monitor disease activity. On the other hand, CCT is a promising non-invasive tool to detect treatment response in early active BU and dual FA-ICGA Score is very helpful to evaluate retinal vasculitis and choroiditis quantitatively.Trial registration numberNCT03871361.

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Section: Clinical Sciencementioning

confidence: 78%

Efficacy and safety of abatacept to treat active birdshot uveitis: a prospective open label interventional proof-of-concept trial

Schauwvlieghe

Calster

Herbort³

et al. 2022

Br J Ophthalmol

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“…Also, although the photopic flicker peak time is regarded as the most sensitive parameter in BCR, other ERGs, including scotopic responses, are also affected. 2 , 4 , 5 , 17 – 20 Some studies have suggested that analysis of oscillatory potentials from dark-adapted ERG or multifocal ERG parameters could be more sensitive. The electrooculogram at baseline has also been correlated with long-term outcome.…”

Section: Discussionmentioning

confidence: 99%

“… 21 Such abnormalities will be missed in purely photopic full-field testing. 17 , 18 One possible approach would be the use of portable recordings to identify patients who might then undergo more extended recordings.…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological Assessment in Birdshot Chorioretinopathy: Flicker Electroretinograms Recorded With a Handheld Device

Waldie

Hobby

Chow

et al. 2022

Trans. Vis. Sci. Tech.

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“…Chiquet et al showed that mfERG abnormalities were correlated with functional and anatomical parameters [ 68 ]. The same group reported a deterioration of the mfERG during a 5-year follow-up, where the visual acuity and visual field remained unchanged, suggesting a higher sensitivity of the mfERG in monitoring disease progression [ 69 ].…”

Section: Other Testsmentioning

confidence: 99%

Birdshot Chorioretinopathy: A Review

Bousquet

Duraffour

Debillon

et al. 2022

JCM

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Birdshot chorioretinopathy (BSCR) is a bilateral chronic inflammation of the eye with no extraocular manifestations. BSCR affects middle-aged individuals from European descent and is strongly associated with the human leucocyte antigen (HLA)-A29 allele. The immune mechanisms involved are not fully understood, but recent advances have shown the role of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in disease pathogenesis. Multimodal imaging, including fluorescein angiography, indocyanine angiography, fundus autofluorescence, and optical coherence tomography, are useful in confirming the diagnosis and monitoring disease activity. Visual field testing is also important to assess the disease progression. To date, there is no consensus for optimal treatment regimen and duration. Local and systemic corticosteroids can be used for short periods, but immunosuppressive or biological therapies are usually needed for the long-term management of the disease. Here, we will review publications focused on birdshot chorioretinopathy to give an update on the pathophysiology, the multimodal imaging, and the treatment of the disease.

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Five-Year Trends in Multifocal Electroretinogram for Patients With Birdshot Chorioretinopathy

Cited by 11 publications

References 46 publications

Efficacy and safety of abatacept to treat active birdshot uveitis: a prospective open label interventional proof-of-concept trial

Efficacy and safety of abatacept to treat active birdshot uveitis: a prospective open label interventional proof-of-concept trial

Electrophysiological Assessment in Birdshot Chorioretinopathy: Flicker Electroretinograms Recorded With a Handheld Device

Birdshot Chorioretinopathy: A Review

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