Fixed drug eruption caused by antibiotics contained in food?

Abstract

disproportionally high, for both length (13.8%) and width (12.2%).For the surgical specimen, shrinkage was less for basal cell carcinoma (BCC) than for hyperkeratotic tumours [squamous cell carcinoma (SCC), carcinoma in situ and actinic keratosis] in both length (L1; 9.7% vs. 13.1%, P < 0.001) and width W1 (7.2% vs. 17%, P < 0.01). There was no relationship between mean shrinkage and either age, sex, body mass index, tobacco/alcohol use, phototype or anatomical units of the face (Table 3).With 100 surgical specimens, this study analysing the shrinkage is the largest collection of facial skin tumours, as the previous largest one compared the shrinkage of 67 specimens. 2 As already reported, 3,4 most of this cutaneous shrinkage occurred immediately after excision, due to the retractile properties of the skin, and there was no significant effect of formalin fixation. Our results were also consistent with the study of Blasdale et al. 5 Tumoral tissue should shrink less than the tumour-free margin, due to its proliferative nature and low flexible structure of tissue protein, lipid or water. Moreover, to the best of our knowledge, we show for the first time that SCC tissue shrinks more than BCC tissue. This might be related to histological composition and tension vectors of surrounding tissue differing from these two types of tumours.With the largest collection of facial skin tumours reported to date, our study showed a mean shrinkage of surgical specimens of 12.8% in length and 11.2% in width; this shrinkage being higher for the tumour-free margin. The greater shrinkage of SCC than BCC needs to be confirmed by a larger prospective study. Clinicians, surgeons and dermatopathologists should be aware of this expected range of shrinkage in order to interpret the histological results and margins appropriately.

Neutrophilic fixed drug eruption, a histopathologic variant or an expected finding?—A report of two cases and review of the literature

“…Food and alcohol have also been implicated in the development of FDE. 1,2 Bullous lesions may occur in more severe presentations. Postinflammatory hyperpigmentation upon resolution of lesions is characteristic.…”

“…Lesions occur at the same location upon re‐exposure to the culprit medication. Food and alcohol have also been implicated in the development of FDE 1,2 . Bullous lesions may occur in more severe presentations.…”