Fixed-Drug Eruption Due to Tetracycline

Tarnowski, William M.

doi:10.1001/archderm.1970.04000080106026

Cited by 4 publications

(5 citation statements)

References 3 publications

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“…Moreover, the phenomenon of cross‐sensitivity and polysensitivity may make it even more difficult to identify a drug in subsequent relapses, 79,80 especially for drugs that are closely related chemically. This is apparent amongst various tetracycline derivatives, 81–83 phenylbutazone derivatives, 84 and other groups 85–87 . In polysensitivity or polyallergic sensitization, the patient is sensitive to various drugs with totally different chemical structures 6,33,88 .…”

Section: Cross‐sensitivity and Polysensitivitymentioning

confidence: 99%

“…Amongst the antibiotics causing FDE are tetracyclines, 80–83,92 penicillin, 93,94 ampicillin, 45,95 amoxicillin, 96 trimethoprim, 97,98 erythromycin, 54,99 rifampicin, 53,100 clarithromycin, 101 and fluoroquinolones 102,103 . Of the sulfa drugs, sulfamethoxazole is the single major antibacterial agent responsible for a large number of FDEs throughout the world 104–107 .…”

Section: Drugs Causing Fdementioning

confidence: 99%

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Fixed drug eruption (FDE): changing scenario of incriminating drugs

Sehgal¹,

Srivastava²

2006

Int J Dermatology

106

115

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Section: Cross‐sensitivity and Polysensitivitymentioning

confidence: 99%

Section: Drugs Causing Fdementioning

confidence: 99%

Fixed drug eruption (FDE): changing scenario of incriminating drugs

Sehgal¹,

Srivastava²

2006

Int J Dermatology

106

115

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“…Fixed drug reactions have rarely been noted intraorally or on the entire body [15,16]. In addition, many patients had previously received tetracycline prior to the fixed drug incident, with one patient receiving up to five documented courses prior to the reaction [17]. Notably absent from the literature are more severe and widespread dermatologic reactions such as Stevens-Johnson syndrome (SJS) and Drug Rash with Eosinophilia and Systemic Symptoms (DRESS), which has rarely been associated with other tetracycline derivatives such as minocycline and doxycycline.…”

Section: Resultsmentioning

confidence: 99%

Tetracycline Allergy

Hamilton

Guarascio

2019

Pharmacy

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Despite the widespread use of tetracycline antibiotics since the late 1940s, tetracycline hypersensitivity reactions have rarely been described in the literature. A comprehensive PubMed search was performed, including allergic and serious adverse reactions attributed to the tetracyclines class of antibiotics. Of the evaluated tetracycline analogs, minocycline was attributed to the greatest overall number and severity of serious adverse events reported in the literature, with notable reactions primarily reported as respiratory and dermatologic in nature. Reactions to tetracycline have also been well described in the literature, and although dermatologic reactions are typically less severe in comparison with minocycline and doxycycline, various reports of anaphylactic reactions exist. Although doxycycline has been noted to have had the fewest reports of severe allergic reactions, rare descriptions of life-threatening reactions are still reported in the literature. Allergic reactions regarding tetracyclines are rare; however, adverse reaction type, severity, and frequency among different tetracycline analogs is somewhat variable. A consideration of hypersensitivity and adverse reaction incidence should be performed prior to the selection of individual tetracycline entities.

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“…Later, the tendency for tetracycline to stain developing teeth was discovered while photo sensitivity and onycholysis were subsequently added to the warning information on the p:1ckage insert. Only within the past decade, however, have scattered reports appeared incriminating tetra cycline as a cause of fixed drug eruptions (2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Eruptionmentioning

confidence: 99%