Fixed drug eruption on the tongue due to clarithromycin

Alonso, Juanjo; Melgosa, A Callejo; Gonzalo, M. J. Fuentes; García, Camino López

doi:10.1111/j.0105-1873.2005.0650h.x

Cited by 17 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the lesions on the lower back were compatible with PFDE. Some cases of PFDE induced by clarithromycin have been reported 2‐5 . However, to the best of our knowledge, this is the first report of a coexisting NPFDE and PFDE due to this particular drug.…”

Section: Discussionmentioning

confidence: 69%

Nonpigmenting and pigmenting fixed drug eruptions due to clarithromycin

et al. 2021

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 69%

Nonpigmenting and pigmenting fixed drug eruptions due to clarithromycin

et al. 2021

View full text Add to dashboard Cite

“…[123] A FDE is characterized by the presence of a single or multiple, pruritic, well circumscribed erythematous plaques or macules. These lesions have a tendency to recur at same sites and heal with residual hyperpigmentation.…”

Section: Discussionmentioning

confidence: 99%

Fixed drug eruption due to clarithromycin

Malkarnekar

Naveen

2013

J Res Pharm Pract

View full text Add to dashboard Cite

Fixed drug eruption (FDE) is an unusual adverse effect of any drug, especially antibiotics like clarithromycin. Herein we report a case of clarithromycin induced FDE in a 30-year-old man who presented with recurrent erythematous and pruritic cutaneous lesions on the lower lip, right hand and left thigh. The lesions were initially misdiagnosed as lichen planus and treated with topical steroids. Each recurrence was at the same site and the lesions faded within 2 weeks leaving behind violacceous pigmentation. All the cutaneous lesions were reproduced following an oral provocation test thus confirming the diagnosis of clarithromycin induced FDE, which is a rare occurrence. When it does occur, it is often misdiagnosed, so physicians should be aware of this condition in order to prevent future recurrences as it causes a lot of cosmetic and physical discomfort to the patient.

show abstract

“…The utility of PT in IM-ADRs caused by quinolones and trimethoprim-sulfamethoxazole (TMP-SMX) is notoriously poor [112,119,120]. PT has been demonstrated to be effective in a small number of antibiotic-associated SJS/TEN [114,121–123], AGEP [70,112,120,124,125], FDE [126–128], DRESS [112,129], MPE [130] and EM [131] case series. To date, success with PT in cases of suspected antiretroviral hypersensitivity has been limited to abacavir.…”

Section: Historical Approaches To T-cell-mediated Hypersensitivitiesmentioning

confidence: 99%

Old dog begging for new tricks: current practices and future directions in the diagnosis of delayed antimicrobial hypersensitivity

Konvinse

Phillips

White

et al. 2016

Current Opinion in Infectious Diseases

View full text Add to dashboard Cite

Purpose of review Antimicrobials are a leading cause of severe T-cell-mediated adverse drug reactions (ADRs). The purpose of this review is to address the current understanding of antimicrobial cross-reactivity and the ready availability of and evidence for in vitro, in vivo and ex vivo diagnostics for T-cell-mediated ADRs. Recent findings Recent literature has evaluated the efficacy of traditional antibiotic allergy management including patch testing, skin prick testing, intradermal testing and oral challenge. While patch and intradermal testing are specific for the diagnosis of immune-mediated (IM) ADRs, they suffer from drug-specific limitations in sensitivity. The use of ex vivo diagnostics, especially ELISpot has been highlighted as a promising new approach to assigning causality. Knowledge of true rates of antimicrobial cross-reactivity aids empirical antibiotic choice in the setting of previous IM-ADRs. Summary In an era of increasing antimicrobial resistance and use of broad-spectrum antimicrobial therapy, ensuring patients are assigned the correct “allergy label” is essential. Re-exposure to implicated antimicrobials, especially in the setting of severe adverse cutaneous reaction is associated with significant morbidity and mortality. The process through which an antibiotic label gets assigned, acted on and maintained is still imprecise. Predicting T-cell-mediated ADRs via personalised approaches, including HLA-typing may pave future pathways to safer antimicrobial prescribing guidelines.

show abstract

Fixed drug eruption on the tongue due to clarithromycin

Cited by 17 publications

References 10 publications

Nonpigmenting and pigmenting fixed drug eruptions due to clarithromycin

Nonpigmenting and pigmenting fixed drug eruptions due to clarithromycin

Fixed drug eruption due to clarithromycin

Old dog begging for new tricks: current practices and future directions in the diagnosis of delayed antimicrobial hypersensitivity

Contact Info

Product

Resources

About