Flagellate Dermatitis After Bleomycin

The Difference Between Polymyxin B and Polymyxin E in Causing Skin Hyerpigmentation

“…In addition to its known inflammatory effects, IL-6 also inhibits the proliferation and melanogenesis of human melanocytes, When the skin is hyperpigmented, IL-6 is often feedback overexpression which may be for regulation (Jawdat et al, 2004;Mattos et al, 2017). At the same time, studies have shown that mast cell-derived factors (including histamine) can stimulate Langerhans cell migration and are related to the melanin production pathway (Miori et al, 1990). Matzneller et al reported that polymyxin E could decrease inflammatory cytokines, including IL-6, in the blood of L lipopolysaccharide-challenged healthy volunteers in a model of human endotoxiemia (Matzneller et al, 2017).…”