Flagellated Magnetotactic Bacteria as Controlled MRI-trackable Propulsion and Steering Systems for Medical Nanorobots Operating in the Human Microvasculature

Martel, Sylvain; Mohammadi, Mohammad; Felfoul, Ouajdi; Zhao, Lidan; Pouponneau, Pierre

doi:10.1177/0278364908100924

Cited by 412 publications

(292 citation statements)

References 32 publications

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“…This class of bacteria synthesizes nanomagnets in their cell membrane, providing a permanent magnet of the order of M = 1 × 10 −16 A m 2 [11,12]. These magnetosomes enable them to be very easily remotely controlled by a magnetic field, which orients the motion of the bacteria by a magnetic torque [13]. The motion of the driven magnetotactic bacteria Magnetococcus marinus strain MC-1 is experimentally studied here in the presence of a steady Poiseuille flow.…”

Section: Introductionmentioning

confidence: 99%

Destabilization of a flow focused suspension of magnetotactic bacteria

et al. 2016

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Active matter is a new class of intrinsically out-of equilibrium material with intriguing properties. The recent upsurge of studies in this field has mostly focused on the spontaneous behavior of these systems. Yet, many systems evolve under external constraints and driving forces, being subjected to both flow and various taxis. We present a new experimental system based on the directional control of magnetotactic bacteria which enables quantitative investigations to complement the challenging theoretical description of such systems. We explore the behavior of self-propelled magnetotactic bacteria as a particularly rich and versatile class of driven matter, whose behavior can be studied under a range of hydrodynamic and magnetic field stimuli. In particular we demonstrate that the competition between cell orientation toward a magnetic field and hydrodynamic flow lead not only to jetting, but to a new pearling instability. This model system illustrates new structuring capabilities of driven active matter.

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Section: Introductionmentioning

confidence: 99%

Destabilization of a flow focused suspension of magnetotactic bacteria

et al. 2016

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“…Nano robots induce oral analgesia, Desensitize tooth; manipulate the tissue to re-align and straighten irregular set of teeth and to improve durability of teeth. Further it is explained that how nano robots are used to do preventive, restorative, curative procedures [26,27]. Nano dental techniques involve many tissue engineering procedures for major tooth repair.…”

Section: Nano Robots In Dentistrymentioning

confidence: 99%

Brief Review on Nano Robots in Bio Medical Applications

Sivasankar¹,

Durairaj

2012

Adv Robot Autom

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Nano-robots are the robots that are simply known as that controllable machine at the nano (10 -9 ) meter or molecular scale, composed of nano-components. More specifically, nano robotics refers to the still largely hypothetical nanotechnology engineering discipline of designing and building nano robots. Even though the field of nano robotics is fundamentally different from that of the macro robots due to the differences in scale and material, there are many similarities in design and control techniques that eventually could be projected and applied. Due to the modern scientific capabilities, it has become possible to attempt the creation of nano robotic devices and interface them with the macro world for control. There are countless such machines which exist in nature and there is an opportunity to build more of them by mimicking nature. Nowadays these nano robots play a vital role in the field of Bio Medicine. Especially in the treatment of cancer, Cerebral Aneurysm, kidney stones removal, also to remove the defected part in our DNA structure and some other treatments that has the greatest aid to save human lives. This paper guides to the recent research on nano robots in the Bio medical applications.

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“…Magnetotactic bacteria were initially used as bacterial microrobots to push a 3 μm polystyrene bead to a desired orientation at an average speed of 7.5 μm/s (Martel et al 2006). Then magnetotactic bacteria were also used to transport drugs to tumors (Martel et al 2009a(Martel et al , 2009b. Recently, magnetotactic bacteria were firstly demonstrated to carry and separate pathogen (Chen et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Controlled regular locomotion of algae cell microrobots

Xie

Jiao

Tung

et al. 2016

Biomed Microdevices

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Algae cells can be considered as microrobots from the perspective of engineering. These organisms not only have a strong reproductive ability but can also sense the environment, harvest energy from the surroundings, and swim very efficiently, accommodating all these functions in a body of size on the order of dozens of micrometers. An interesting topic with respect to random swimming motions of algae cells in a liquid is how to precisely control them as microrobots such that they swim according to manually set routes. This study developed an ingenious method to steer swimming cells based on the phototaxis. The method used a varying light signal to direct the motion of the cells. The swimming trajectory, speed, and force of algae cells were analyzed in detail. Then the algae cell could be controlled to swim back and forth, and traverse a crossroad as a microrobot obeying specific traffic rules. Furthermore, their motions along arbitrarily set trajectories such as zigzag, and triangle were realized successfully under optical control. Robotize algae cells can be used to precisely transport and deliver cargo such as drug particles in microfluidic chip for biomedical treatment and pharmacodynamic analysis. The study findings are expected to bring significant breakthrough in biological drives and new biomedical applications.

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Flagellated Magnetotactic Bacteria as Controlled MRI-trackable Propulsion and Steering Systems for Medical Nanorobots Operating in the Human Microvasculature

Cited by 412 publications

References 32 publications

Destabilization of a flow focused suspension of magnetotactic bacteria

Destabilization of a flow focused suspension of magnetotactic bacteria

Brief Review on Nano Robots in Bio Medical Applications

Controlled regular locomotion of algae cell microrobots

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