Flash desorption of low‐volatility compounds deposited on a heated solid substrate (90°C) by dripping liquid methanol

Abstract

Rationale Desorption of low‐volatility compounds deposited on a solid substrate by dripping a methanol drop was explored. Methods Low‐volatility compounds such as drugs and explosives were deposited/dried on the substrate at 35°C. After increasing the temperature to 90°C, 5 μL methanol was dripped onto the substrate. The desorbed analytes were ionized by alternating current corona discharge and analyzed by mass spectrometry. Results Flash desorption for drugs and explosives was observed accompanied by the rapid evaporation of methanol. However, saccharides, fullerene, cholesterol, and gramicidin S were not detected by the present method. Conclusions It was suggested that surface‐active compounds were desorbed at the peripheral front region of the spreading liquid methanol accompanied by rapid evaporation of methanol.

Rapid characterization of drugs in a single hair using thermal desorption ionization mass spectrometry

“…22–24 The major ionization mechanism of TDI-MS for analysis of drugs in a single hair was similar to the flash desorption ionization mechanism. 25 First, the hair sample was heated by the MCH. And then the high voltage direct current was applied to the hair.…”

Rapid Characterization of Drugs in Biological Fluid and Seized Material Using Thermal-Assisted Carbon Fiber Ionization Mass Spectrometry

“…The analytes on the carbon fiber could be evaporated by the heated MCH and ionized by charged species, which were produced by the corona discharge. The major ionization mechanism of TCFI included two-step desorption–ionization, which was similar to the flash desorption mechanism . The analyte was initially thermally desorbed, and then, the evaporated analyte was protonated by the reactive charged species.…”

“…The major ionization mechanism of TCFI included two-step desorption−ionization, which was similar to the flash desorption mechanism. 46 The analyte was initially thermally desorbed, and then, the evaporated analyte was protonated by the reactive charged species. Compared with CFI, TCFI can ionize both the nonpolar anthracene and the polar tripeptide of glycyl−glycyl− glycine (see Figure S3), because the solvent vaporization in this process could facilitate the desorption of analytes from the carbon fiber.…”