FLASH Radiotherapy: What Can FLASH's Ultra High Dose Rate Offer to the Treatment of Patients With Sarcoma?

Cengel, Keith A.; Kim, Michele M.; Diffenderfer, Eric S.; Busch, Theresa M.

doi:10.1016/j.semradonc.2024.02.001

Seminars in Radiation Oncology

2024

DOI: 10.1016/j.semradonc.2024.02.001

|View full text |Cite

FLASH Radiotherapy: What Can FLASH's Ultra High Dose Rate Offer to the Treatment of Patients With Sarcoma?

Keith A. Cengel,

Michele M. Kim,

Eric S. Diffenderfer

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The Role of Radiotherapy in the Contemporary Management of Patients With Sarcoma: Opportunities to Improve Patient Outcomes

Kirsch

2024

Seminars in Radiation Oncology

View full text Add to dashboard Cite

The Role of Radiotherapy in the Contemporary Management of Patients With Sarcoma: Opportunities to Improve Patient Outcomes

Kirsch

2024

Seminars in Radiation Oncology

View full text Add to dashboard Cite

Major contributors to FLASH sparing efficacy emerge from murine skin studies: dose rate, total dose per fraction, anesthesia and oxygenation

Pogue,

Thomas,

Tavakkoli

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

BackgroundNormal tissue sparing from radiation damage upon ultra-high dose rate irradiation, known as the FLASH effect with an equivalent tumor response, has been widely reported in murine skin models, and translation of this type of radiotherapy to humans has already begun, with skin sparing being a primary outcome expected.MethodsThis study reviews the status of the field, focusing on the proposed mechanisms and skin response assays, outlining what has become known in terms of input parameters that might control the magnitude of the FLASH effect.ResultsMurine studies have largely focused on acute damage responses, developing over 3–8 weeks, to single doses of FLASH versus conventional dose rate (CDR), suggesting that at dose rates above tens of Gray per second, with a total dose of more than 20 Gy, the FLASH effect is induced. Fractionated delivery appears to be possible, although fraction sizes >17 Gy appear to be needed for sparing efficacy. The interplay between the dose rate and total dose per fraction remains to be fully elucidated. Oxygen is a modulator of efficacy, with both hypoxia and hyperoxia diminishing the effect of FLASH. Measurement of transient changes in oxygen levels is possible and may be a marker of treatment efficacy.ConclusionTaken together, murine skin data provide important information for translational studies, despite the associated limitations. Studies of later-term sparing effects, as well as studies on pig skin, are needed to take the next step in assessing translational FLASH efficacy. The control of biological factors, such as tissue oxygenation, may be required to understand and control the response.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

FLASH Radiotherapy: What Can FLASH's Ultra High Dose Rate Offer to the Treatment of Patients With Sarcoma?

Cited by 2 publications

References 93 publications

The Role of Radiotherapy in the Contemporary Management of Patients With Sarcoma: Opportunities to Improve Patient Outcomes

The Role of Radiotherapy in the Contemporary Management of Patients With Sarcoma: Opportunities to Improve Patient Outcomes

Major contributors to FLASH sparing efficacy emerge from murine skin studies: dose rate, total dose per fraction, anesthesia and oxygenation

Contact Info

Product

Resources

About