Flash technology-based self-assembly in nanoformulation: Fabrication to biomedical applications

Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment

“…ThermoDox [ 133 ], a thermo-sensitive liposome already in the clinical stage, is a good example. Although there are advances in mass production technologies (e.g., Microfluidics [ 134 ], Non-wetting formwork technology [ 135 ] and Coaxial turbulent jet mixer [ 136 ]), further breakthroughs are still demanded to speed up the clinical transformation of stimulus-responsive drug delivery materials. Fourth, criteria for toxicity assessment of nanomaterials as delivery systems are lacking, which makes the evaluation indicators for each team in the stage of developing new nanomaterials often varying.…”

Advanced Microfluidic Technologies for Lipid Nano-Microsystems from Synthesis to Biological Application

“…In this perspective, flash technologies facilitate nanoparticles' self-assembly and formulation in a low-cost, high-throughput, and controllable manner. Flash nano complexation (FCN) and flash nanoprecipitation (FCP) involve rapid mixing in confined impingement jets mixers (CIJM) or multiple inlet vortex mixers (MIVM) [135] (Figure 3). FCN and core-shell nanostructures have been combined for oral gene delivery application.…”

Effect of the disulfide bond and polyethylene glycol on the degradation and biophysicochemical properties of polyurethane micelles

“…18 Many powerful nanoformulations have been developed by sophisticated design and fabrication, which involves combining many functional molecules to satisfy all the demands. 19–22 However, to our knowledge, the principal characteristics of the nanoformulations approved by the Food and Drug Administration (FDA), such as those of liposomal doxorubicin, albumin-based nanoparticles and paclitaxel-loaded micelles, are simple and have unambiguous structure. 23,24 Despite the remarkable advances achieved in the recent few decades, there are no multifunctional nanotechnology therapeutic products clinically approved by the FDA for cancer therapy so far.…”