Flash tooth whitening: A friendly formulation based on a nanoencapsulated reductant

Babot-Marquillas, Clara; Sánchez-Martín, María-Jesús; Rodríguez-Martínez, Jorge; Estelrich, Joan; Busquets, Maria Antònia; Valiente, Manuel

doi:10.1016/j.colsurfb.2020.111241

Cited by 8 publications

(8 citation statements)

References 50 publications

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“…There are several factors that put oral health at risk, such as the popularity of whitening systems with their side effects or the excessive consumption of acidic foods and beverages. − Demineralization caused by regular exposure of the tooth enamel to acids, such as those produced within accumulations of bacterial plaque from dietary carbohydrates, removes mineral ions from HA crystals and may cause a caries lesion. Demineralization in early caries lesions can be reversed by calcium and phosphate in saliva. − However, mature tooth enamel is acellular and does not regenerate itself after substantial loss. , Mechanical properties of the macroscopic enamel tissue are highly dependent on the alignment and orientation of HA crystals.…”

Section: Introductionmentioning

confidence: 99%

Combination of Two Synchrotron Radiation-Based Techniques and Chemometrics to Study an Enhanced Natural Remineralization of Enamel

et al. 2022

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The limitations to assess dental enamel remineralization have been overcome by a methodology resulting from the appropriate combination of synchrotron radiation-based techniques on both, infrared microspectroscopy and micro X-ray diffraction, with the help of specific data mining. Since amelogenin plays a key role in modulating the mineralization of tooth enamel, we propose a controlled ion release for fluorapatite structural ions (Ca 2+ , PO 4 3– , and F – , also including Zn 2+ ) by using weak acid and weak base ion-exchange resins in the presence of amelogenin to remineralize the surface of etched teeth. This combination provides the necessary ions for enamel remineralization and a guide for crystal growth due to the protein. Remineralized tooth samples were analyzed by applying the indicated methodology. The synchrotron data were treated using principal component analysis and multivariate curve resolution to analyze the mineral layer formed in the presence and absence of amelogenin. The remineralizing treatment created a fluorapatite layer free of carbonate impurities and with a similar orientation to that of the natural enamel thanks to amelogenin contribution.

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Section: Introductionmentioning

confidence: 99%

Combination of Two Synchrotron Radiation-Based Techniques and Chemometrics to Study an Enhanced Natural Remineralization of Enamel

et al. 2022

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“…The spectra were acquired in the reflection mode and for each one, 64 scans were carried out from 4000 cm −1 to 600 cm −1 with 4 cm −1 spectral resolution at room temperature, using 10×10 μm 2 of aperture size. A gold mirror was used as background reference the drug transport until the dentin tissue efficiently increasing the diffusion process, despite the drug concentration per application was much lower than in the CBD and OLV control groups (Table 2) [15]. Furthermore, CBD and OLV control groups are completely overlapped in this analysis, confirming that OLV could be used as CBD analog in this experiment.…”

Section: Study Of the Treatments' Effect Over The Dentinmentioning

confidence: 55%

“…This methodology has been described in a previous work [21]. DPPC liposomes were obtained by hydration and mechanical dispersion following a modified method previously described [15]. The complete description of these syntheses can be found in the ESM.…”

Section: Drug Delivery System Synthesismentioning

confidence: 99%

“…CD-MOFs are biocompatible MOFs and they do not induce any toxicity up to 2000 μg/mL of concentration. And DPPC liposomes are well-known as DDS, and they have been already applied successfully in dentistry for other applications such as tooth whitening [15]. Besides, another important aspect for both systems is to verify whether scaling up the production of the formulation from the laboratory level to the industrial level is technically and economically possible.…”

Section: Introductionmentioning

confidence: 99%

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Efficient controlled release of cannabinoids loaded in γ-CD-MOFs and DPPC liposomes as novel delivery systems in oral health

2023

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Olivetol (OLV), as a cannabidiol (CBD) analog, was incorporated in γ-cyclodextrin metal-organic frameworks (γ-CD-MOFs) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes as potential analgesic drug delivery systems (DDS) for dental hypersensitivity (DH) treatment. These DDS have been scarcely employed in oral health, being the first time in case of MOFs loaded with cannabinoids. In vitro experiments using bovine teeth were performed to verify if the drug is able to reach the dentin, where it can flow to the pulp tissues and exert its analgesic effect; enamel and dentin regions were analyzed by synchrotron radiation-based FTIR microspectroscopy. Principal component analysis (PCA) was used to process the spectroscopic data as a powerful chemometric tool, and it revealed a similar behavior in both regions. The studied DDS have been characterized by different techniques, and is was demonstrated that DDS is an efficient way to carry the drug through dental tissues without compromising their structure. Graphical Abstract

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“…If left untreated, the early reversible lesion can progress to the point of being irreversible [14,15]. Another factor that puts oral health at risk and makes it necessary to find a solution is the popularity of the whitening systems and their side effects, such as dental erosion and hypersensitivity [16][17][18][19]. The mature enamel has no residual cellular components that can carry out the repair when it is damaged, so the restoration depends on physicochemical events at the tooth surface [1,2]; here are protective factors that can prevent or reverse it, such as salivary proteins, calcium, phosphate, salivary flow and fluoride in saliva [5,20,21].…”

Section: Introductionmentioning

confidence: 99%

The power of weak ion-exchange resins assisted by amelogenin for natural remineralization of dental enamel: an in vitro study

2022

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This study aims to develop an innovative dental product to remineralize dental enamel by a proper combination of ion-exchange resins as controlled release of mineral ions that form dental enamel, in the presence of amelogenin to guide the appropriate crystal growth. The novel product proposed consists of a combination of ion-exchange resins (weak acid and weak base) individually loaded with the remineralizing ions: Ca2+, PO43− and F−, also including Zn2+ in a minor amount as antibacterial, together with the protein amelogenin. Such cocktail provides onsite controlled release of the ions necessary for enamel remineralization due to the weak character of the resins and at the same time, a guiding tool for related crystal growth by the indicated protein. Amelogenin protein is involved in the structural development of natural enamel and takes a key role in controlling the crystal growth morphology and alignment at the enamel surface. Bovine teeth were treated by applying the resins and protein together with artificial saliva. Treated teeth were evaluated with nanoindentation, scanning electron microscopy and energy-dispersive X-ray spectroscopy. The innovative material induces the dental remineralization creating a fluorapatite layer with a hardness equivalent to sound enamel, with the appropriate alignment of corresponding nanocrystals, being the fluorapatite more acid resistant than the original mineral. Our results suggest that the new product shows potential for promoting long-term remineralization leading to the inhibition of caries and protection of dental structures.

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Flash tooth whitening: A friendly formulation based on a nanoencapsulated reductant

Cited by 8 publications

References 50 publications

Combination of Two Synchrotron Radiation-Based Techniques and Chemometrics to Study an Enhanced Natural Remineralization of Enamel

Combination of Two Synchrotron Radiation-Based Techniques and Chemometrics to Study an Enhanced Natural Remineralization of Enamel

Efficient controlled release of cannabinoids loaded in γ-CD-MOFs and DPPC liposomes as novel delivery systems in oral health

The power of weak ion-exchange resins assisted by amelogenin for natural remineralization of dental enamel: an in vitro study

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