Flav7 + DOX co-loaded separable microneedle for light-triggered chemo-thermal therapy of superficial tumors

Wang, Huixin; Wang, Wenshen; Li, Chengpan; Xu, Ao; Qiu, Bensheng; Li, Fenfen; Ding, Weiping

doi:10.1016/j.cej.2021.131913

Cited by 25 publications

(18 citation statements)

References 55 publications

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Section: Stimuli-responsive Microneedlesmentioning

confidence: 99%

“…In this lane, a study by Wang et al has reported on a DOXloaded light-responsive MN patch for chemo-thermal therapy of superficial malignant tumors (Figure 6). 152 Generally, inorganic materials such as metallic NPs, carbon nanotubes, and semiconducting polymeric NPs are utilized as photothermal agents. However, they pose the issue of both biocompatibility and biodegradability.…”

Section: Exogenous Stimuli-responsive Microneedlesmentioning

confidence: 99%

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Stimuli-Responsive Microneedles as a Transdermal Drug Delivery System: A Demand-Supply Strategy

et al. 2022

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Microneedles are one of the most prominent approaches capable of physically disrupting the stratum corneum without devastating the deeper tissues to deliver both small molecules and macromolecules into the viable epidermis/dermis for local/systemic effects. Over the past two decades, microneedles have caught the attention of many researchers because of their outstanding advantages over oral and parenteral drug delivery systems such as self-administration, pain-free, steady-plasma concentration maintenance, avoidance of first-pass hepatic biotransformation, and so on. So far, scientists have reported various types of microneedle patches to deliver the loaded therapeutics as soon as the microneedles are inserted into the skin, regardless of the demand for therapeutics to treat a specific condition. This way of drug delivery can lead to potential risks such as poor therapeutic efficacy or drug overdose. The stimuliresponsive microneedles are the most predominant tool to achieve the on-demand/need-based drug delivery, leading to safe and effective treatment. Various natural and synthetic polymers that can undergo significant transitions such as swelling, shrinking, dissolution, or disintegration play a pivotal role in the development of stimuli-responsive microneedles. The current Review provides brief information about the history, emergence, type, and working principles of microneedles. Furthermore, it selectively discusses various exogenous and endogenous stimuli-responsive microneedles along with their mechanism of action involved in treating different disease conditions. Collaterally, the emergence of "closed-loop" combinatorial stimuli-responsive microneedle patches for precise delivery of therapeutics is meticulously canvassed. Subsequently, it covers the patents of different stimuli-responsive microneedles and further highlights the existing challenges and future perspectives concerning clinical application and large-scale production.

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Section: Stimuli-responsive Microneedlesmentioning

confidence: 99%

Section: Exogenous Stimuli-responsive Microneedlesmentioning

confidence: 99%

Stimuli-Responsive Microneedles as a Transdermal Drug Delivery System: A Demand-Supply Strategy

et al. 2022

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“…Only after being heated to a certain temperature, the temperature-sensitive liposomes will release the chemotherapeutic agents [ 54 ]. A newly designed microneedle consisting of photothermal agents and DOX is used to realize a NIR-II light-triggered heating, local drug release, and NIR-II fluorescence imaging at the same time [ 39 ]. Furthermore, through a programmable and wireless control of heating duration, the amount of DOX released from the temperature-sensitive liposomes is successfully controlled [ 63 ].…”

Section: Cancer Treatments Combined With Thermal Therapymentioning

confidence: 99%

Synergetic Thermal Therapy for Cancer: State-of-the-Art and the Future

et al. 2022

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As a safe and minimal-invasive modality, thermal therapy has become an effective treatment in cancer treatment. Other than killing the tumor cells or destroying the tumor entirely, the thermal modality results in profound molecular, cellular and biological effects on both the targeted tissue, surrounding environments, and even the whole body, which has triggered the combination of the thermal therapy with other traditional therapies as chemotherapy and radiation therapy or new therapies like immunotherapy, gene therapy, etc. The combined treatments have shown encouraging therapeutic effects both in research and clinic. In this review, we have summarized the outcomes of the existing synergistic therapies, the underlying mechanisms that lead to these improvements, and the latest research in the past five years. Limitations and future directions of synergistic thermal therapy are also discussed.

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“…Previous reports also have evidenced that a single type of chemotherapeutic drug in a safe dose normally exhibited insufficient capability to inhibit tumor recurrence, , which was frequently seen in CA4 administration for cancer therapy. , Deep into the mechanism of vascular disruption, CA4 specifically binds to tubulin and subsequently depolymerizes the microtubule of the vascular endothelial cells, which eventually cuts off the blood flow into the central area of the solid tumor, preferentially enhancing the inhibition of central tumor growth. Thereby, to further elevate the tumor recurrence inhibition, suppressing the proliferation of the peripheral tumor cells by a combined alternative drug would be promising. ,, Doxorubicin (DOX) is a classic chemotherapeutic drug that has been studied for decades, − presenting satisfactory antitumor ability via intercalating into DNA and disrupting the DNA pairs. Consequently, sequentially releasing CA4 and DOX to completely inhibit the tumor growth in the central and peripheral areas might provide great potential in elevating tumor eradiation.…”

Section: Introductionmentioning

confidence: 99%

Implantable Sandwich-like Scaffold/Fiber Composite Spatiotemporally Releasing Combretastatin A4 and Doxorubicin for Efficient Inhibition of Postoperative Tumor Recurrence

Fang

Liu

Wang

et al. 2022

ACS Appl. Mater. Interfaces

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Tumor recurrence is a critical conundrum in the postoperative therapy, on account of severe bleeding with disseminated tumor cells, residual tumor cells, and the rich nutrient and oxygen supply transported to tumors by the abundant blood vessels. Biodegradable drug-loaded implants, inserted in the resection cavity right away upon the surgery, possess bleeding prevention and efficient chemotherapeutic capabilities, considered to be a promising strategy to efficiently inhibit the recurrence of the solid tumor. Here, we developed a sandwich-like composite consisting of the combretastatin A4 (CA4)-loaded 3D-printed scaffold and doxorubicin (DOX)-loaded electrospun fiber (Scaf-

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Flav7 + DOX co-loaded separable microneedle for light-triggered chemo-thermal therapy of superficial tumors

Cited by 25 publications

References 55 publications

Stimuli-Responsive Microneedles as a Transdermal Drug Delivery System: A Demand-Supply Strategy

Stimuli-Responsive Microneedles as a Transdermal Drug Delivery System: A Demand-Supply Strategy

Synergetic Thermal Therapy for Cancer: State-of-the-Art and the Future

Implantable Sandwich-like Scaffold/Fiber Composite Spatiotemporally Releasing Combretastatin A4 and Doxorubicin for Efficient Inhibition of Postoperative Tumor Recurrence

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