Flavanoids from Dalea elegans: Chemical reassignment and determination of kinetics parameters related to their anti-tyrosinase activity

Peralta, Mariana Andrea; Santi, María Daniela; Agnese, Alicia Mariel; Cabrera, José Luis; Ortega, Marı́a Gabriela

doi:10.1016/j.phytol.2014.10.012

Cited by 26 publications

(23 citation statements)

References 22 publications

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“…13 C-NMR (CDCl 3 , 75 MHz) δ (ppm) 196.2, 163.7, 162.2, 159.6, 138.7, 134.6, 128.7, 128.6, 127.9, 125.9, 125.1, 121.6, 106.3, 103.3, 96.9, 78.9, 43.2, 25.7, 21.8, 17.8. These data are in agreement with those reported [32].…”

Section: Resultssupporting

confidence: 94%

Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathway

et al. 2019

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Inflammation represents an adaptive response generated by injuries or harmful stimuli. Natural remedies represent an interesting alternative to traditional therapies, involving several biochemical pathways. Besides, the valorization of agrochemical wastes nowadays seems to be a feasible way to reduce the health spending and improve the accessibility at bioactive natural compounds. In this context, the chemical composition of three Glycyrrhiza glabra L. (licorice) leaf extracts, obtained through maceration or ultrasound-assisted method (fresh and dried leaves) was investigated. A guided fractionation obtained three main components: pinocembrin, glabranin and licoflavanone. All the extracts showed similar antioxidant properties, evaluated by 2,2′-diphenyl-1-picrylhydrazyl (DPPH) or 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) Diammonium Salt (ABTS) assay, while, among the isolated compounds, licoflavanone exhibited the best antioxidant activity. The anti-inflammatory activity of the extracts and the purified compounds was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages. Extract C and licoflavanone showed a good anti-inflammatory activity without affecting cell viability, as they decreased nitrite levels even when used at 12.5 μg/mL (p < 0.005) and 50 μM concentration (p < 0.001), respectively. Interestingly, licoflavanone markedly decreased pro-inflammatory cytokines and cyclooxygenase 2/inducible nitric oxide synthase (COX-2/iNOS) expression levels (p < 0.001). A modulation of nuclear factor kappa B/mitogen-activated protein kinases (NF-kB/MAPK) pathway underlay such behavior, highlighting the potential of this natural compound as a new scaffold in anti-inflammatory drug research.

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Section: Resultssupporting

confidence: 94%

Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathway

et al. 2019

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“…17 Oxidative stress is caused by an imbalance between the produc- Extraction and isolation 67 The flavonoid 8PP (Fig. 1) was isolated and purified from roots of 68 D. elegans (Cafaratti et al 1994) and its structure was characterized 69 by UV, NMR 1H and 13C and HRMS, according to Peralta et al (2014). 70 The purity of 8PP was determined as 95% by using a Varian (Palo Alto, 71 CA) ProStar HPLC equipment which was coupled with a UV detec-72 tor (Varian).…”

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confidence: 99%

Antifungal activity of a prenylated flavonoid from Dalea elegans against Candida albicans biofilms

et al. 2015

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“…Pinocembrin 5 was active only against MCF-7 cancer cells (▶Table 2) and showed little inhibition against S. aureus (▶ Table 1). It is a widespread flavonoid in plants [22] and has also been found in propolis [23].…”

Section: Mcf-7 Skbr3mentioning

confidence: 99%

“…In our antibacterial assays, it showed not to be active against S. aureus (▶ Table 2). Isoglabranin has been isolated for the first time from Derris rariflora, a Brazilian member of Leguminosae [24], and then reported from Dalea elegans (Fabaceae) [22] and Helichrysum teretifolium (Compositae) [25].…”

Section: Mcf-7 Skbr3mentioning

confidence: 99%

Cytotoxic, Anti-bacterial, and Wound-healing Activity of Prenylated Phenols from the Kurdish Traditional Medicinal Plant Onobrychis Carduchorum (Fabaceae)

Clericuzio

Hussain

Amin

et al. 2020

Planta Medica International Open

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Onobrychis carduchorum (Fabaceae) is a plant widely employed in Kurdish traditional medicine to cure wounds, inflammations, and other skin diseases. We could isolate ten different polyphenols from the acetone extract of this plant: 1–4 are isoflavones, having a genistein skeleton; 5–7 are flavanones, having a naringenin skeleton; and 8–10 are prenylated dihydro-stilbenes. In particular, 8–10 have been isolated, so far, only from Glycyrrhiza glabra (liquorice). Many of the above prenylated phenols showed significant toxicity on some human breast cancer cell lines, and a relevant growth inhibition of Staphylococcus aureus strains. In addition, 9 and 10 had marked wound healing activity. It is suggested that these bioactivities are responsible, at least partly, for the plant’s traditional use.

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Flavanoids from Dalea elegans: Chemical reassignment and determination of kinetics parameters related to their anti-tyrosinase activity

Cited by 26 publications

References 22 publications

Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathway

Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathway

Antifungal activity of a prenylated flavonoid from Dalea elegans against Candida albicans biofilms

Cytotoxic, Anti-bacterial, and Wound-healing Activity of Prenylated Phenols from the Kurdish Traditional Medicinal Plant Onobrychis Carduchorum (Fabaceae)

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