Flavanones from the Twigs and Barks of &lt;i&gt;Artocarpus lakoocha&lt;/i&gt; Having Antiplasmodial and Anti-TB Activities

Boonyaketgoson, Sirada; Du, Yongle; Murillo, Ana L. Valenciano; Cassera, María B.; Kingston, David G. I.; Trisuwan, Kongkiat

doi:10.1248/cpb.c20-00080

Cited by 8 publications

(4 citation statements)

References 12 publications

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“…The content of phenols, flavonoids, and carotenoids was determined on the fresh extract of the flowers of both plants. Total carotenoids in the flowers were estimated as per the method of Lee [ 17 ], where fresh sample (5 g) was mixed with 50 mL of a mixture of n-hexane/acetone/ethanol ( v/v ; 50:25:25) and placed in an incubator shaker (Excella E24, Eppendorf, Mumbai, India) at 25 °C for 10 min at 200 rpm. The mixture was centrifuged (Eppendorf 5430R, Hamburg, Germany) to separate the sediment and supernatant at 6500 rpm at 4 °C for 10 min.…”

Section: Methodsmentioning

confidence: 99%

“…The tree of AL is mostly known for its wood and edible fruits due to its excellent nutraceutical properties [ 14 ]. In the foothills of the Himalayas in Nepal, the leaves and flowers of this tree also act as fresh fodder for lactating animals due to its excellent source of bioactive compounds [ 15 , 16 , 17 ]. Traditionally, it is also taken as medicine for people suffering from liver-related diseases [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Artocarpus lakoocha Roxb. and Artocarpus heterophyllus Lam. Flowers: New Sources of Bioactive Compounds

Gupta

Rather

Jha

et al. 2020

Plants

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Artocarpus heterophyllus Lam. (AH) and Artocarpus lakoocha Roxb. (AL) are two endemic plants that grow on the Asian continent. To date, their applications have been aimed at using their fruit as a food source or for some of their therapeutic virtues. In this study, attention was given to the flowers of AH and AL. Initially, the cytotoxicity of the phytoextracts was assessed, and the content of minerals, phenols, and flavonoids was determined. Furthermore, some antioxidant components were identified by HPLC. Furthermore, the ability of AH and AL extracts to modulate the gene expression of some targets involved in the antioxidant response was studied. The results obtained highlighted the nutritional and antioxidant value of the AH and AL flower extracts. This study will contribute to enhancing the use of AH and AL flowers as potential supplements in human nutrition.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Artocarpus lakoocha Roxb. and Artocarpus heterophyllus Lam. Flowers: New Sources of Bioactive Compounds

Gupta

Rather

Jha

et al. 2020

Plants

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“…Cyclocommunin displays modest anti-proliferative effects against hepatocellular carcinoma cells (IC50 = 14-33 M depending on cell line) whereas Art-A and Art-B were inactive against these HCC cell lines (Ma et al 2010). Recently, it was reported that cyclocommunin displays a significant antimycobacterial activity against Mycobacterium tuberculosis (laboratory strain H37Ra) with a minimum inhibitory concentration (MIC) of 12.3 µM (Boonyaketgoson et al 2020).…”

Section: Prenyl Flavonoids From Artocarpus Elasticusmentioning

confidence: 99%

Anticancer mechanism of artonin E and related prenylated flavonoids from the medicinal plant Artocarpus elasticus

Bailly

2021

Asian J Nat Prod Biochem

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Abstract. Bailly C. 2021. Anticancer mechanism of artonin E and related prenylated flavonoids from the medicinal plant Artocarpus elasticus. Asian J Nat Prod Biochem 19: 44-56. Plants of the Artocarpus genus are largely distributed throughout tropical Asia and Oceania. Species such as A. altilis (Parkinson) Fosberg and A. heterophyllus Lam. are popular trees known as breadfruit and jackfruit, respectively. They contain a large structural diversity of bioactive prenylated flavonoids. Here we have focused on the less known species Artocarpus elasticus Reinw. ex Blume which is well distributed in southeast Asia, and used in traditional medicine to treat dysentery, tuberculosis, and other diseases. Numerous prenylated flavonoids have been isolated from the leaves and bark of A. elasticus, such as artocarpesin, artocarpin, artelastin, and many others. They are endowed with antioxidant, anti-inflammatory, and anticancer properties. A focus is made of the subgroup of compounds designated artonins, with the derivative artonin E as a lead anticancer agent. Art-E has revealed marked anticancer effects in vitro and in vivo, after oral administration. The mechanism of action of Art-E is discussed, to highlight the structural and functional analogy between Art-E and the antitumor natural product morusin. Both compounds trigger TRAIL-mediated apoptosis of cancer cells. They can be considered further for the development of novel anticancer agents.

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“…The heartwoods of AL have been traditionally used in Thai folk medicine for various purposes, such as treating tapeworm infections, relieving skin conditions and itching, and acting as a kidney tonic [2]. There have been many reports for its biological activities, such as antiviral (for HSV-1) [3], anti-microbial [4,5], anti-malarial [6], anti-tuberculosis [7], anti-plasmodial [7], anti-atherosclerotic [8], antidiarrhea [9], anti-diabetic [10], wound healing [11], anti-browning for peeling fruit [12], anti-inflammatory [8,9], anti-cancer [13], anti-oxidation [13,14], and skin whitening properties [15]. In addition, bioactive compounds that have skin-whitening properties in AL are mainly found as oxyresveratrol (ORV) and resveratrol, according to recent research reports [16].…”

Section: Introductionmentioning

confidence: 99%

Development of a Ready-to-Use Oxyresveratrol-Enriched Extract from Artocarpus lakoocha Roxb. Using Greener Solvents and Deep Eutectic Solvents for a Whitening Agent

Saesue,

Thanomrak,

Prompan

et al. 2024

Cosmetics

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Oxyresveratrol (ORV) is naturally found in Artocapus lakoocha Roxb. (AL), similar to resveratrol. This AL extract has demonstrated considerable importance in dietary supplements and cosmetics for its anti-tyrosinase and antioxidant properties. There is a great demand for ORV in the cosmetic and pharmaceutical industries. Traditionally, harsh solvents have been used to extract ORV from AL. This study aims to address this issue by introducing green technology with a ready-to-use extract for the enrichment of ORV extraction from AL using deep eutectic solvents (DESs). Thirty-three DESs were synthesized and characterized. The extraction efficiency of these DESs was evaluated by ORV content (g ORV/kg dried plant) and compared with the conventional solvents, analyzed by validated HPLC. Notably, two synthesized DESs, namely choline chloride/citric acid/water (2:1:3) (DES10) and choline chloride/xylose (1:1) (DES17), showed higher ORV content than the conventional solvents and were therefore selected for optimization of extraction conditions using Box–Behnken designs, considering three variable levels: time, temperature, and water as co-solvents. Interestingly, the biological activities of ORV-enriched extracts from DES10 and DES17 were evaluated, and the results showed that they were 74-fold and 252-fold more potent than kojic acid in terms of tyrosinase inhibitory activity. DES17 was 17- fold more potent antioxidants than ascorbic acid. The morphology of AL powder before and after extraction with DESs under SEM suggested that DESs have the same mechanism as classical organic solvents. These ORV-enriched extracts can be directly incorporated into cosmetic formulations and production scales without the need to prepare a stock solution and are therefore referred to as ready-to-use extracts. This study successfully pioneered the use of DESs for environmentally friendly and highly efficient ORV extraction from AL to produce ready-to-use extracts and applications for the pharmaceutical and cosmetic industries.

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Flavanones from the Twigs and Barks of <i>Artocarpus lakoocha</i> Having Antiplasmodial and Anti-TB Activities

Cited by 8 publications

References 12 publications

Artocarpus lakoocha Roxb. and Artocarpus heterophyllus Lam. Flowers: New Sources of Bioactive Compounds

Artocarpus lakoocha Roxb. and Artocarpus heterophyllus Lam. Flowers: New Sources of Bioactive Compounds

Anticancer mechanism of artonin E and related prenylated flavonoids from the medicinal plant Artocarpus elasticus

Development of a Ready-to-Use Oxyresveratrol-Enriched Extract from Artocarpus lakoocha Roxb. Using Greener Solvents and Deep Eutectic Solvents for a Whitening Agent

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