Flavonoid Constituents from Eupatorium altissimum L. (Compositae)

Dobberstein, R.H.; Tin‐Wa, M.; Fong, Harry H. S.; Crane, F.A.; Farnsworth, Norman R.

doi:10.1002/jps.2600660441

Cited by 24 publications

(6 citation statements)

References 12 publications

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“…Rutin was reported by Sato and Moreira (1985) as a component of D. littoralis (cited as Eupatorium littorale). Dobberstein et al (1974Dobberstein et al ( , 1977, Herz et al (1978) Wagner et al (1972f, 19721) E. leucolepis 574'/63', 4'/56783', 4'/56783'5', 3'156784'5', -/5678/3'4'-MDO, -/56785'/3'4'-MDO, -/56783'4' Herz and Kulanthaivel (1982) Eupatorium: Eupatorium, a genus of 48 species, is North American, occurring from the Rocky Mountains eastward. Eupatorium has been fairly well studied chemically so that we have information on flavonoids from over 30 species.…”

Section: Flavonoids Of Eupatorieaementioning

confidence: 97%

Flavonoids of the Sunflower Family (Asteraceae)

Bohm

Stuessy

2001

120

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This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machines or similar means, and storage in data banks. This book is dedicated to:Arthur Cronquist Outstanding plant systematist and major contributor to understanding taxonomic relationships within Asteraceae and Ralph E. Alston (1925Alston ( -1967) Visionary natural products chemist and geneticist who pioneered the use of chemical data in studies of plant systematics and evolution PrefaceCertainly many of the readers of this book will remember the early developments of chemosystematics in the late 1950s. We ourselves remember the excitement of these new data bearing on plant interrelationships. The hopes were high, the techniques were rapidly evolving, the quantities of data were large, and young workers were eagerly enthusiastic. Some even went so far as to predict that chemical data would soon replace morphological information as the basis for plant classification. These overly zealous predictions did not materialize, of course, as the history of plant systematics has amply shown during the past two centuries. If there is any distinct characteristic of systematics it is synthesis, as Lincoln Constance (1964) called it, the "unending synthesis." New tools generate new data and provide insights on additional dimensions of plant relationships. This will never change-we will continue to discover new tools and new data in the years ahead, and they will continue to be incorporated into the predictive general reference system of classification.The earlier efforts in chemosystematics focused on secondary plant products: alkaloids, betacyanins, carbohydrates, cyanogenic glycosides, glucosinolates, lipids, terpenoids, and especialiy flavonoids. The latter were particularly well suited for chemosystematic investigation for several reasons: ease of isolation and characterization, small amounts of plant material needed for analysis, stability of compounds especially through routine preparation of herbarium specimens, and low cost to obtain useful information. As a result of these considerable advantages, literally thousands of studies on use of flavonoids in plant systematics have been published. Although now with the present zest for macromolecular data from DNA restriction sites and sequences, there are fewer workers and laboratories dedicated to flavonoid chemosystematic studies; twenty years ago they were the new currency of exciting data in plant systematics.Because of many workers historically interested in the sunflower family, Asteraceae (or Compositae), in part due to its large size (approximately 23,000 species;Bremer, 1994), and because hundreds of flavonoid compounds were discovered in this family, many chemosystematic investigations have been completed on various taxa. Many studies came from the laboratories of R. A. Alston, B. L. Turner, and T. J. Mabry in the Department of Botany ...

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Section: Flavonoids Of Eupatorieaementioning

confidence: 97%

Flavonoids of the Sunflower Family (Asteraceae)

Bohm

Stuessy

2001

120

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“…spicata, whilst 5-hydroxy-7,4 0 -dimethoxyflavone (7,4 0 -di-O-methylapigenin) (66) (Brieskorn and Dömling, 1967) has been obtained from S. marmorea. Other flavones, 5,3 0 -dihydroxy-7,4 0 -dimethoxyflavone (pilloin) (67) (Núñez-Alarcón, 1971) and 5-hydroxy-6,7,3 0 ,4 0 -tetramethoxyflavone (70) (Dobberstein et al, 1974), have been isolated from S. soluta. The 3 0 -O-methyl ether of pilloin (68) was identified in extracts of S. massoniana var.…”

Section: Flavonesmentioning

confidence: 99%

A chemotaxonomic study of nine Canarian Sideritis species

et al. 2009

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“…The compound has shown a moderate cytotoxic effect [101,102] on MK-1 (human gastric adenocarcinoma), HeLa (human uterus carcinoma), B16F10 (murine melanoma), and 26-L5 (murine colon cancer) cell lines. Interestingly, the same compound was totally inactive against P-388 (lymphatic leukemia) cell line [103]. Eupatorin inhibited the growth of MDA-MB-468 (human breast carcinoma) cell line in a dose dependent manner with an IC 50 of 0.5 μM.…”

Section: Anticancer Activity Of Artemisinin and A Annua Flavonoidsmentioning

confidence: 99%

Flavonoids from Artemisia annua L. as Antioxidants and Their Potential Synergism with Artemisinin against Malaria and Cancer

Ferreira¹,

et al. 2010

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Artemisia annua is currently the only commercial source of the sesquiterpene lactone artemisinin. Since artemisinin was discovered as the active component of A. annua in early 1970s, hundreds of papers have focused on the anti-parasitic effects of artemisinin and its semi-synthetic analogs dihydroartemisinin, artemether, arteether, and artesunate. Artemisinin per se has not been used in mainstream clinical practice due to its poor bioavailability when compared to its analogs. In the past decade, the work with artemisinin-based compounds has expanded to their anti-cancer properties. Although artemisinin is a major bioactive component present in the traditional Chinese herbal preparations (tea), leaf flavonoids, also present in the tea, have shown a variety of biological activities and may synergize the effects of artemisinin against malaria and cancer. However, only a few studies have focused on the potential synergistic effects between flavonoids and artemisinin. The resurgent idea that multi-component drug therapy might be better than monotherapy is illustrated by the recent resolution of the World Health Organization to support artemisinin-based combination therapies (ACT), instead of the previously used monotherapy with artemisinins. In this critical review we will discuss OPEN ACCESSMolecules 2010, 15 3136 the possibility that artemisinin and its semi-synthetic analogs might become more effective to treat parasitic diseases (such as malaria) and cancer if simultaneously delivered with flavonoids. The flavonoids present in A. annua leaves have been linked to suppression of CYP450 enzymes responsible for altering the absorption and metabolism of artemisinin in the body, but also have been linked to a beneficial immunomodulatory activity in subjects afflicted with parasitic and chronic diseases.

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Flavonoid Constituents from Eupatorium altissimum L. (Compositae)

Cited by 24 publications

References 12 publications

Flavonoids of the Sunflower Family (Asteraceae)

Flavonoids of the Sunflower Family (Asteraceae)

A chemotaxonomic study of nine Canarian Sideritis species

Flavonoids from Artemisia annua L. as Antioxidants and Their Potential Synergism with Artemisinin against Malaria and Cancer

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