Flavonoids are promising safe therapy against COVID-19

Alzaabi, Moza Mohamed; Hamdy, Rania; Ashmawy, Naglaa S.; Hamoda, Alshaimaa M.; Alkhayat, Fatemah; Khademi, Neda Naser; Joud, Sara Mahmoud Abo Al; El‐Keblawy, Ali; Soliman, Sameh S. M.

doi:10.1007/s11101-021-09759-z

Cited by 119 publications

(108 citation statements)

References 168 publications

(193 reference statements)

Supporting

Mentioning

106

Contrasting

Order By: Relevance

“…They also belong to secondary plant metabolites found in fruits, vegetables, seeds, roots, propolis, and other plant products such as tea and wine. With over 9000 structurally identified flavonoids, research has associated many of these compounds with multiple healthpromoting effects, ranging from nutraceutical, pharmaceutical, medicinal, and cosmetic applications to their antioxidative, anti-inflammatory anti-mutagenic, and anti-carcinogenic properties [56,57]. In plants, they play an important role as components of cells to defend against pathogens, insects, and other stressful environments [58][59][60][61][62].…”

Section: Flavonoids and Their Antiviral Propertiesmentioning

confidence: 99%

Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review

Kaul

Paul

Kumar

et al. 2021

IJMS

View full text Add to dashboard Cite

The ongoing COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a globally leading public health concern over the past two years. Despite the development and administration of multiple vaccines, the mutation of newer strains and challenges to universal immunity has shifted the focus to the lack of efficacious drugs for therapeutic intervention for the disease. As with SARS-CoV, MERS-CoV, and other non-respiratory viruses, flavonoids present themselves as a promising therapeutic intervention given their success in silico, in vitro, in vivo, and more recently, in clinical studies. This review focuses on data from in vitro studies analyzing the effects of flavonoids on various key SARS-CoV-2 targets and presents an analysis of the structure-activity relationships for the same. From 27 primary papers, over 69 flavonoids were investigated for their activities against various SARS-CoV-2 targets, ranging from the promising 3C-like protease (3CLpro) to the less explored nucleocapsid (N) protein; the most promising were quercetin and myricetin derivatives, baicalein, baicalin, EGCG, and tannic acid. We further review promising in silico studies featuring activities of flavonoids against SARS-CoV-2 and list ongoing clinical studies involving the therapeutic potential of flavonoid-rich extracts in combination with synthetic drugs or other polyphenols and suggest prospects for the future of flavonoids against SARS-CoV-2.

show abstract

Section: Flavonoids and Their Antiviral Propertiesmentioning

confidence: 99%

Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review

Kaul

Paul

Kumar

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Since bioavailability is the determining factor of the in vivo bioactivity of flavonoids, numerous attempts have been and still are being made by scientists to increase bioavailability, even more so now that the importance of flavonoids in ameliorating various communicable and non-communicable diseases is being discovered and becoming widely known. The recognition of flavonoids as possible prophylactics and therapeutics has increased markedly since the first reports of their inhibitory effects against emerging, devastating pathogenic viruses such as Ebola [260] and currently COVID-19 [261] and further including currently not so widely known, but potentially fatal pandemic-causing viruses like Lassa virus (belonging to the Arenaviruses, which also includes Junin virus, Machupo virus, and Chapare virus) [262]. For increasing bioavailability of individual flavonoids, several methods have been tried (the use of nanotechnology for the effective delivery of flavonoids will be discussed in a later section).…”

Section: Enhancement Of Flavonoid Bioavailability Through Various Means Other Than Nanotechnologymentioning

confidence: 99%

Nanotechnology Applications of Flavonoids for Viral Diseases

et al. 2021

View full text Add to dashboard Cite

Recent years have witnessed the emergence of several viral diseases, including various zoonotic diseases such as the current pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Other viruses, which possess pandemic-causing potential include avian flu, Ebola, dengue, Zika, and Nipah virus, as well as the re-emergence of SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome) coronaviruses. Notably, effective drugs or vaccines against these viruses are still to be discovered. All the newly approved vaccines against the SARS-CoV-2-induced disease COVID-19 possess real-time possibility of becoming obsolete because of the development of ‘variants of concern’. Flavonoids are being increasingly recognized as prophylactic and therapeutic agents against emerging and old viral diseases. Around 10,000 natural flavonoid compounds have been identified, being phytochemicals, all plant-based. Flavonoids have been reported to have lesser side effects than conventional anti-viral agents and are effective against more viral diseases than currently used anti-virals. Despite their abundance in plants, which are a part of human diet, flavonoids have the problem of low bioavailability. Various attempts are in progress to increase the bioavailability of flavonoids, one of the promising fields being nanotechnology. This review is a narrative of some anti-viral dietary flavonoids, their bioavailability, and various means with an emphasis on the nanotechnology system(s) being experimented with to deliver anti-viral flavonoids, whose systems show potential in the efficient delivery of flavonoids, resulting in increased bioavailability.

show abstract

“…ADME properties of target compounds were predicted using Swiss-ADME server [25], using compounds in SMILES format [26]. Two different filters, Lipinski's rule of five and Ghose filter, were used to evaluate the drug-like properties.…”

Section: Pharmacokinetics and Drug Likeness Filter And Target Predictionmentioning

confidence: 99%

New Bioactive Fused Triazolothiadiazoles as Bcl-2-Targeted Anticancer Agents

Hamdy

Jones

El-Sadek

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

A series of 3-(6-substituted phenyl-[1,2,4]-triazolo[3,4-b]-[1,3,4]-thiadiazol-3-yl)-1H-indoles (5a–l) were designed, synthesized and evaluated for anti-apoptotic Bcl-2-inhibitory activity. Synthesis of the target compounds was readily accomplished through a reaction of acyl hydrazide (1) with carbon disulfide in the presence of alcoholic potassium hydroxide to afford the corresponding intermediate potassium thiocarbamate salt (2), which underwent cyclization reaction in the presence of excess hydrazine hydrate to the corresponding triazole thiol (3). Further cyclisation reaction with substituted benzoyl chloride derivatives in the presence of phosphorous oxychloride afforded the final 6-phenyl-indol-3-yl [1,2,4]-triazolo[3,4-b]-[1,3,4]-thiadiazole compounds (5a–l). The novel series showed selective sub-micromolar IC50 growth-inhibitory activity against Bcl-2-expressing human cancer cell lines. The most potent 6-(2,4-dimethoxyphenyl) substituted analogue (5k) showed selective IC50 values of 0.31–0.7 µM against Bcl-2-expressing cell lines without inhibiting the Bcl-2-negative cell line (Jurkat). ELISA binding affinity assay (interruption of Bcl-2-Bim interaction) showed potent binding affinity for (5k) with an IC50 value of 0.32 µM. Moreover, it fulfils drug likeness criteria as a promising drug candidate.

show abstract

Flavonoids are promising safe therapy against COVID-19

Cited by 119 publications

References 168 publications

Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review

Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review

Nanotechnology Applications of Flavonoids for Viral Diseases

New Bioactive Fused Triazolothiadiazoles as Bcl-2-Targeted Anticancer Agents

Contact Info

Product

Resources

About