Flavonoids from Maytenus buchananii as potential cholera chemotherapeutic agents

Tebou, Perrin Lanversin Foning; Tamokou, Jean-De-Dieu; Ngnokam, David; Voutquenne-Nazabadioko, Laurence; Kuiaté, Jules Roger; Bag, Prasanta K.

doi:10.1016/j.sajb.2016.12.019

Cited by 23 publications

(16 citation statements)

References 38 publications

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“…For example, among the compounds extracted from Maytenus buchananii , quercetin‐3‐O‐[α‐L‐rhamnopyranosyl‐(1 → 6)‐β‐D glucopyranoside] ( 9 ) with a disaccharide group at the same position was the better inhibitor of S . aureus growth than amentoflavone‐7″,4‴‐dimethyl‐ether ( 6 ) with monosaccharide group (quercetin‐3‐O‐β‐D‐glucopyranoside; Tebou et al, ). Substitution that decrease activity is methoxylation at position 3.…”

Section: Structure–activity Relationshipmentioning

confidence: 99%

Antibacterial activity of flavonoids and their structure–activity relationship: An update review

Farhadi

Khameneh

Iranshahi

et al. 2018

Phytotherapy Research

489

305

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Based on World Health Organization reports, resistance of bacteria to well-known antibiotics is a major global health challenge now and in the future. Different strategies have been proposed to tackle this problem including inhibition of multidrug resistance pumps and biofilm formation in bacteria and development of new antibiotics with novel mechanism of action. Flavonoids are a large class of natural compounds, have been extensively studied for their antibacterial activity, and more than 150 articles have been published on this topic since 2005. Over the past decade, some promising results were obtained with the antibacterial activity of flavonoids. In some cases, flavonoids (especially chalcones) showed up to sixfold stronger antibacterial activities than standard drugs in the market. Some synthetic derivatives of flavonoids also exhibited remarkable antibacterial activities with 20-to 80-fold more potent activity than the standard drug against multidrug-resistant Gram-negative and Gram-positive bacteria (including Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus). This review summarizes the ever changing information on antibacterial activity of flavonoids since 2005, with a special focus on the structure-activity relationship and mechanisms of actions of this broad class of natural compounds.

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Section: Structure–activity Relationshipmentioning

confidence: 99%

Antibacterial activity of flavonoids and their structure–activity relationship: An update review

Farhadi

Khameneh

Iranshahi

et al. 2018

Phytotherapy Research

489

305

View full text Add to dashboard Cite

show abstract

“…The need for ecologically safe compounds as therapeutic agents against drug-resistant microorganisms has driven many studies toward medicinal plants. Literature shows thousands of plant species that have been tested in vitro against many fungal and bacterial strains, and a good number of medicinal plant extracts and pure compounds have now been proven to be active against fungi, Gram-positive and Gram-negative bacteria [ 2 – 5 ]. Medicinal plants contain therapeutic amount of secondary metabolites including flavonoids.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activities of flavonoid glycosides from Graptophyllum grandulosum and their mechanism of antibacterial action

Tagousop

Tamokou

Ekom

et al. 2018

BMC Complement Altern Med

128

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BackgroundThe search for new antimicrobials should take into account drug resistance phenomenon. Medicinal plants are known as sources of potent antimicrobial compounds including flavonoids. The objective of this investigation was to evaluate the antimicrobial activities of flavonoid glycosides from Graptophyllum grandulosum, as well as to determine their mechanism of antibacterial action using lysis, leakage and osmotic stress assays.MethodsThe plant extracts were prepared by maceration in organic solvents. Column chromatography of the n-butanol extract followed by purification of different fractions led to the isolation of five flavonoid glycosides. The antimicrobial activities of extracts/compounds were evaluated using the broth microdilution method. The bacteriolytic activity was evaluated using the time-kill kinetic method. The effect of extracts on the red blood cells and bacterial cell membrane was determined by spectrophotometric methods.ResultsChrysoeriol-7-O-β-D-xyloside (1), luteolin-7-O-β-D-apiofuranosyl-(1 → 2)-β-D-xylopyranoside (2), chrysoeriol-7-O-β-D-apiofuranosyl-(1 → 2)-β-D-xylopyranoside (3), chrysoeriol-7-O-α-L-rhamnopyranosyl-(1 → 6)-β-D-(4"-hydrogeno sulfate) glucopyranoside (4) and isorhamnetin-3-O-α-L-rhamnopyranosyl-(1 → 6)-β-D-glucopyranoside (5) were isolated from G. grandulosum and showed different degrees of antimicrobial activities. Their antibacterial activities against multi-drug-resistant Vibrio cholerae strains were in some cases equal to, or higher than those of ciprofloxacin used as reference antibiotic. The antibacterial activities of flavonoid glycosides and chloramphenicol increased under osmotic stress (5% NaCl) whereas that of vancomycin decreased under this condition. V. cholerae suspension treated with flavonoid glycosides, showed a significant increase in the optical density at 260 nm, suggesting that nucleic acids were lost through a damaged cytoplasmic membrane. A decrease in the optical density of V. cholerae NB2 suspension treated with the isolated compounds was observed, indicating the lysis of bacterial cells. The tested samples were non-toxic to normal cells highlighting their good selectivity index.ConclusionsThe results of the present study indicate that the purified flavonoids from G. glandulosum possess antimicrobial activities. Their mode of antibacterial activity is due to cell lysis and disruption of the cytoplasmic membrane upon membrane permeability.

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“…Black tea derived thearubigin and theaflavins are anti-angiogenic [43]. The constituent epicatechin of Maytenus buchananii (a small evergreen tree), a traditional Cameroonian anti-cancer treatment, has an excellent MIC of 32 to 128 μg/ml against Staphylococcus aureus [56].…”

Section: Phenolsmentioning

confidence: 99%

“…Quercetin-3-O-β-D-glucopyranoside also has an EC50 of 1.42 μg/ml and a TEAC of 89.76 μg/ml [56]. Maytenus was initially studied for maytansine, an excessively cytotoxic antileukemic, single macrocyclic ring compound.…”

Section: Phenolsmentioning

confidence: 99%

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Nutraceuticals: Curative Integrative Cancer Treatment

Nwanodi¹

2017

Altern Integr Med

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Statement of Purpose: Although 75% of breast cancer patients may use integrative medicine, only 11.5% earlystage breast cancer patients believe integrative medicine has anticancer activity. The gap in users of and firm believers in integrative medicine indicates a need to increase awareness of integrative medicine's applicability to curative cancer treatment. As diet, nutraceuticals, and traditional Chinese medicine are used by up to 82% of cancer patients who use integrative medicine, this paper focuses on nutraceuticals. As female cancer patients are most likely to use integrative medicine, nutraceuticals specific to breast, cervical, endometrial, and ovarian cancer are reviewed.Methods: PubMed searches in September 2016 and January 2017, and accompanying hand searches were performed for English language, free full text articles published from 2012 onwards. Search terms were combinations of the key words: Homeopathy, phytochemicals, breast cancer, cervical cancer, endometrial cancer, ovarian cancer, cancer, prevention, treatment. Curative nutraceutical treatments were taken from these searches. Supplemental hand searches were performed as needed. Findings:Integrative nutraceutical therapies are based on biologic plausibility. Individual nutraceuticals are frequently comprised of numerous phytochemical types, and have multiple mechanisms of action. Agonistantagonist mechanisms are not exclusive to phytoestrogens, complicating which derivative or whole nutraceutical to use. Research on breast and cervical cancer inhibitors has seemingly outpaced that for endometrial and ovarian cancer. Breast cancer inhibitors include terpenes, isoflavones, organosulphurs, organoselenium compounds, and withanolides. Conclusion and Significance:Potential nutraceutical candidates for curative cancer treatment abound. Discerning which constituents, which extraction method, and which delivery method to use for an efficacious treatment is an essential, lengthy process. If nutraceuticals such as limonene and Kahalalide F move forward to Phase III trials a nutraceutical cancer treatment pipeline may be established. Withaferin-A and derivatives for breast and ovarian cancer appear to be the leading gynecologic cancer nutraceutical drug candidates.

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Flavonoids from Maytenus buchananii as potential cholera chemotherapeutic agents

Cited by 23 publications

References 38 publications

Antibacterial activity of flavonoids and their structure–activity relationship: An update review

Antibacterial activity of flavonoids and their structure–activity relationship: An update review

Antimicrobial activities of flavonoid glycosides from Graptophyllum grandulosum and their mechanism of antibacterial action

Nutraceuticals: Curative Integrative Cancer Treatment

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