Flavonoids from Scutellaria barbata D. Don exert antitumor activity in colorectal cancer through inhibited autophagy and promoted apoptosis via ATF4/sestrin2 pathway

Liu, Lianfang; Liu, Tianya; Tao, Weiwei; Liao, Naikai; Yan, Qiuying; Li, Liu; Tan, Jun; Shen, Weixing; Cheng, Haibo; Sun, Dongdong

doi:10.1016/j.phymed.2022.154007

Cited by 16 publications

(11 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that resveratrol and epigallocatechin gallate (EGCG), the active ingredient of green tea, enhanced cell death by blocking the drug-induced protective autophagy flux and demonstrated synergistic anticancer effect, thereby overcoming drug resistance (87)(88)(89). Flavonoids from S. baicalensis Georgi inhibited autophagy, promoted cell apoptosis, and exerted anti-CRC activity by regulating the ATF4/sestrin2 pathway (90). Sophora flavescens Aiton extract activated the AMPK/mTOR pathway, increased the autophagy flux of colon cancer, and induced apoptosis (91).…”

Section: Cell Deathmentioning

confidence: 99%

Research progress of traditional Chinese medicine as sensitizer in reversing chemoresistance of colorectal cancer

Lin

Yang

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

In recent years, the incidences and mortalities from colorectal cancer (CRC) have been increasing; therefore, there is an urgent need to discover newer drugs that enhance drug sensitivity and reverse drug tolerance in CRC treatment. With this view, the current study focuses on understanding the mechanism of CRC chemoresistance to the drug as well as exploring the potential of different traditional Chinese medicine (TCM) in restoring the sensitivity of CRC to chemotherapeutic drugs. Moreover, the mechanism involved in restoring sensitivity, such as by acting on the target of traditional chemical drugs, assisting drug activation, increasing intracellular accumulation of anticancer drugs, improving tumor microenvironment, relieving immunosuppression, and erasing reversible modification like methylation, have been thoroughly discussed. Furthermore, the effect of TCM along with anticancer drugs in reducing toxicity, increasing efficiency, mediating new ways of cell death, and effectively blocking the drug resistance mechanism has been studied. We aimed to explore the potential of TCM as a sensitizer of anti-CRC drugs for the development of a new natural, less-toxic, and highly effective sensitizer to CRC chemoresistance.

show abstract

Section: Cell Deathmentioning

confidence: 99%

Research progress of traditional Chinese medicine as sensitizer in reversing chemoresistance of colorectal cancer

Lin

Yang

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…Scutellarin and scutellarein are the natural oxyflavonoids obtained from Erigeron breviscapus ; they are naturally glycosylated, perform a wide range of functions and have a variety of medicinal properties [ 13 , 141 , 142 ]. The therapeutic properties are as follows: vasodilating, acting as an anticoagulant and being tumor suppressive.…”

Section: Regulation Of Autophagy By Scutellaria Fl...mentioning

confidence: 99%

“…The various anticancer mechanisms of these flavones have been described in different cancer cell cultures and xenografted animal preclinical models, demonstrating the potential of these compounds to exert anti-inflammatory, cell death-inducing, antimetastatic and antiangiogenic properties in different cancer types [ 8 , 9 , 10 , 11 ]. Furthermore, among several other mechanisms, Scutellaria flavones have been shown to suppress malignant growth through the modulation of autophagy [ 12 , 13 ]. Moreover, depending on various factors, such as the cancer cell type, activated cellular signaling network and molecular characteristics of the isolated compounds, Scutellaria-derived flavonoids can exert antitumor activity [ 13 , 14 ] by inducing autophagic processes [ 12 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, among several other mechanisms, Scutellaria flavones have been shown to suppress malignant growth through the modulation of autophagy [ 12 , 13 ]. Moreover, depending on various factors, such as the cancer cell type, activated cellular signaling network and molecular characteristics of the isolated compounds, Scutellaria-derived flavonoids can exert antitumor activity [ 13 , 14 ] by inducing autophagic processes [ 12 , 15 ]. The present review focused on the potential of Scutellaria flavones to regulate the autophagic machinery in diverse cancer models.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Autophagy Induction by Scutellaria Flavones in Cancer: Recent Advances

Tuli

Bhushan

Kumar³

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

In parallel with a steady rise in cancer incidence worldwide, the scientific community is increasingly focused on finding novel, safer and more efficient modalities for managing this disease. Over the past decades, natural products have been described as a significant source of new structural leads for novel drug candidates. Scutellaria root is one of the most studied natural products because of its anticancer potential. Besides just describing the cytotoxic properties of plant constituents, their molecular mechanisms of action in different cancer types are equally important. Therefore, this review article focuses on the role of the Scutellaria flavones wogonin, baicalein, baicalin, scutellarein and scutellarin in regulating the autophagic machinery in diverse cancer models, highlighting these molecules as potential lead compounds for the fight against malignant neoplasms. The knowledge that autophagy can function as a dual-edged sword, acting in both a pro- and antitumorigenic manner, further complicates the issue, revealing an amazing property of flavonoids that behave either as anti- or proautophagic agents.

show abstract

“…The autophagy process can be a tumor suppressor or a pro-oncogenic mechanism and many studies have revealed the dual role of autophagy, promoting either cell death or cell survival in cancer progression [12]. Consequently, regulation of autophagy using both natural product or synthetic drugs can be used as reliable interventional strategies for cancer treatment [13].…”

Section: Introductionmentioning

confidence: 99%

Baicalein 5, 6, 7-trimethyl ether from Physalis pubescens L. leaves ameliorate the effect of epirubicin in HepG2 cancer cells by inducing apoptosis and autophagy

Al-Ashmawy

Abo-Saif

El-Sherbeni

2022

Preprint

View full text Add to dashboard Cite

Context: flavonoids have a pivotal cytotoxic effect against hepatocellular carcinoma (HCC). Aims To reveal which flavonoid isolated from Physalis pubescens L. leaves exerts the most cytotoxic effect against HepG2 liver cancer cells and if it could ameliorate epirubicin efficacy and safety through regulating apoptosis and autophagy. Methods Baicalein trimethyl ether (BTE), rutin, quercitrin and myricitrin were isolated from Physalis Pubescens L. leaves. HepG2 cells were treated with the isolated flavonoids as well as a combination of BTE and epirubicin. Cell viability was assessed by MTT assay after 48hr treatment. In addition, the chromosomal DNA fragmentation in HepG2 cells, a biochemical hallmark of apoptosis, was assessed. Autophagy and apoptosis markers, ATG7 and TGF-β1, were determined by RT-qPCR. Results BTE showed the best cytotoxic effect against HepG2 cells (IC50 = 95.6 ± 5.849 µg/mL). Combination of epirubicin with (200µg/mL) BTE significantly decreased the IC50 of epirubicin from 2.79 ± 0.626 µg/mL to 0.76 ± 0.258 µg/mL (p = 0.04). Moreover, the same combination significantly increased the IC50 of BTE against WI-38 normal cells (p < 0.0001). DNA fragmentation was increased in HepG2 cells treated with BTE and BTE + epirubicin compared to untreated cells. BTE and BTE + epirubicin significantly downregulated gene expression of TGF-β1 while upregulated ATG7 gene expression. Conclusions BTE (200µg/mL) significantly increased the cytotoxicity of epirubicin against HepG2 cells and increased its safety profile. It could exert anti-hepatocarcinoma effect via increasing apoptosis and autophagy. It could be a promising adjuvant therapy to ameliorate epirubicin cytotoxicity against HCC with less adverse effects.

show abstract

Flavonoids from Scutellaria barbata D. Don exert antitumor activity in colorectal cancer through inhibited autophagy and promoted apoptosis via ATF4/sestrin2 pathway

Cited by 16 publications

References 41 publications

Research progress of traditional Chinese medicine as sensitizer in reversing chemoresistance of colorectal cancer

Research progress of traditional Chinese medicine as sensitizer in reversing chemoresistance of colorectal cancer

Autophagy Induction by Scutellaria Flavones in Cancer: Recent Advances

Baicalein 5, 6, 7-trimethyl ether from Physalis pubescens L. leaves ameliorate the effect of epirubicin in HepG2 cancer cells by inducing apoptosis and autophagy

Contact Info

Product

Resources

About