1999
DOI: 10.1016/s0024-3205(99)00120-4
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Flavonoids: Old and new aspects of a class of natural therapeutic drugs

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Cited by 1,138 publications
(806 citation statements)
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“…In fact, dietary modifications by selected nutritional and botanical agents-for instance, NDGA, EGCG, curcumin, quercetin, and omega-3 fatty acids-favorably influence eicosanoid production and effectively strengthen the enzymatic line of defense against oxidative molecules by retaining NF-κB in the cytoplasm by an inhibitor of NF-κB, IκBα protein [35][36][37][38]. Based on the several reports about the antioxidative effect of ginseng against lipid peroxidation [39], our current study could be a critical point of mechanisms of RGE on AA metabolism through 5-LOX inhibition.…”
Section: Discussionmentioning
confidence: 99%
“…In fact, dietary modifications by selected nutritional and botanical agents-for instance, NDGA, EGCG, curcumin, quercetin, and omega-3 fatty acids-favorably influence eicosanoid production and effectively strengthen the enzymatic line of defense against oxidative molecules by retaining NF-κB in the cytoplasm by an inhibitor of NF-κB, IκBα protein [35][36][37][38]. Based on the several reports about the antioxidative effect of ginseng against lipid peroxidation [39], our current study could be a critical point of mechanisms of RGE on AA metabolism through 5-LOX inhibition.…”
Section: Discussionmentioning
confidence: 99%
“…1 Special attention has been also given to flavonoids due to the many studies that suggest that these compounds have beneficial effects in age-associated diseases such as cardiovascular and cerebrovascular diseases, some forms of cancer and Parkinson's and Alzheimer's diseases. 2 The wide use of flavonoids in the treatment of several diseases requires application of simple and sensitive analytical procedures Vol.…”
Section: Introductionmentioning
confidence: 99%
“…Various flavonoids such as quercetin, naringin, and saponins have been used as a remedy for inflammatory diseases in folk medicine around the world (5,6). Several gastroprotective mechanisms of flavonoids have been suggested including increasing endogenous PG, decreasing histamine secretion, inhibiting Helicobactor pylori, and scavenging oxygen-derived free radicals.…”
mentioning
confidence: 99%