Flavonols reduce aortic atherosclerosis lesion area in apolipoprotein E deficient mice: A systematic review and meta-analysis

Phie, James; Krishna, Smriti Murali; Moxon, Joseph V.; Omer, Safraz Mohamed; Kinobe, Robert T.; Golledge, Jonathan

doi:10.1371/journal.pone.0181832

Cited by 19 publications

(9 citation statements)

References 51 publications

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“…Overexpression of human ApoD could protect drosophila against various extrinsic stresses and extend its normal lifespan ( 45 ). ApoE is an important element in the lipoprotein metabolism and cholesterol transport ( 46 ). Cholesterol plays a key role in vitamin D and steroid hormones synthesis, which is critical to the development of the newborns ( 47 ).…”

Section: Discussionmentioning

confidence: 99%

Quantitative Label-Free Proteomic Analysis of Milk Fat Globule Membrane in Donkey and Human Milk

Zhang

Jiang

Ji³

et al. 2021

Front. Nutr.

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Previous studies have found donkey milk (DM) has the similar compositions with human milk (HM) and could be used as a potential hypoallergenic replacement diet for babies suffering from cow's milk allergy. Milk fat globule membrane (MFGM) proteins are involved in many biological functions, behaving as important indicators of the nutritional quality of milk. In this study, we used label-free proteomics to quantify the differentially expressed MFGM proteins (DEP) between DM (in 4–5 months of lactation) and HM (in 6–8 months of lactation). In total, 293 DEP were found in these two groups. Gene Ontology (GO) enrichment analysis revealed that the majority of DEP participated in regulation of immune system process, membrane invagination and lymphocyte activation. Several significant Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were determined for the DEP, such as lysosome, galactose metabolism and peroxisome proliferator-activated receptor (PPAR) signaling pathway. Our study may provide valuable information in the composition of MFGM proteins in DM and HM, and expand our knowledge of different biological functions between DM and HM.

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Section: Discussionmentioning

confidence: 99%

Quantitative Label-Free Proteomic Analysis of Milk Fat Globule Membrane in Donkey and Human Milk

Zhang

Jiang

Ji³

et al. 2021

Front. Nutr.

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“…ApoE is a crucial element in the lipoprotein metabolism,[ 51 ] lipid transportation,[ 52 ] and clearance of amyloid proteins in brain. [ 53 ] APOE gene locates on the chromosome 19q13.2 with 3 alleles (e2, e3, and e4) and 6 genotypes (E2E2, E2E3, E2E4, E3E3, E3E4, and E4E4).…”

Section: A Polipoprotein S Uperfamilymentioning

confidence: 99%

Relationship between Apolipoprotein Superfamily and Parkinson's Disease

Liu

et al. 2017

Chinese Medical Journal

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Objective:Parkinson's disease (PD) is featured with motor disorder and nonmotor manifestations including psychological symptoms, autonomic nervous system dysfunction, and paresthesia, which results in great inconvenience to the patients’ life. The apolipoprotein (Apo) superfamily, as a group of potentially modifiable biomarkers in clinical practice, is of increasing significance in the diagnosis, evaluation, and prognosis of PD. The present review summarized the current understanding and emerging findings of the relationship between Apo superfamily and PD.Data Sources:All literatures were identified by systematically searching PubMed, Embase, and Cochrane electronic databases with terms “Parkinson disease,” “apolipoprotein,” and their synonyms until May 2017.Study Selection:We have thoroughly examined titles and abstracts of all the literatures that met our search strategy and the full text if the research is identified or not so definite. Reference lists of retrieved articles were also scrutinized for additional relevant studies.Results:The levels of plasma ApoA1 are inversely correlated with the risk of PD and the lower levels of ApoA1 trend toward association with poorer motor performance. Higher ApoD expression in neurons represents more puissant protection against PD, which is critical in delaying the neurodegeneration process of PD. It is suggested that APOE alleles are related to development and progression of cognitive decline and age of PD onset, but conclusions are not completely identical, which may be attributed to different ApoE isoforms. APOJ gene expressions are upregulated in PD patients and it is possible that high ApoJ level is an indicator of PD dementia and correlates with specific phenotypic variations in PD.Conclusions:The Apo superfamily has been proved to be closely involved in the initiation, progression, and prognosis of PD. Apos and their genes are of great value in predicting the susceptibility of PD and hopeful to become the target of medical intervention to prevent the onset of PD or slow down the progress. Therefore, further large-scale studies are warranted to elucidate the precise mechanisms of Apos in PD.

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“…In DM milk fat globule membrane (MFGM), ApoA1 was upregulated in colostrum compared with mature milk [22]. ApoE and ApoH are also crucial elements in the lipoprotein metabolism and cholesterol transport [23,24]. The higher concentrations of ApoE in CM and HM were found in early lactation, and signi cantly decreased over lactation, indicating the importance of cholesterol in the development of the neonate [25,26].…”

Section: Discussionmentioning

confidence: 99%

Comparative Whey Proteome Profiling of Donkey Milk With Human and Cow Milk

Zhang

Jiang

Ji³

et al. 2020

Preprint

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Background: Donkey milk (DM), similar to human milk (HM) in compositions, has been suggested as the best potential hypoallergenic replacement diet for babies suffering from cow milk (CM) protein allergens. Despite advances in proteomics technologies, studies of the DM whey proteome are relatively sparse. In this study, label-free mass spectrometry analysis was conducted to quantitatively identify the differentially expressed whey proteins (DEPs) in DM vs HM group and DM vs CM group. Results: In total, 249 and 418 DEPs were found in these two groups respectively. DEPs were then subjected to intensive bioinformatic analysis. Results revealed that the majority of DEPs participated in lipid metabolic process, regulation of cytokine production, chemical homeostasis and catabolic process. Kyoto Encyclopedia of Gene and Genomes (KEGG) pathways analysis found that these DEPs mainly participated in complement and coagulation cascades, and cholesterol metabolism. Conclusion: These results may provide valuable information in the composition of milk whey proteins in DM, HM and CM, especially for low abundant components, and expand our knowledge of different biological functions between DM and HM or CM.

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Flavonols reduce aortic atherosclerosis lesion area in apolipoprotein E deficient mice: A systematic review and meta-analysis

Cited by 19 publications

References 51 publications

Quantitative Label-Free Proteomic Analysis of Milk Fat Globule Membrane in Donkey and Human Milk

Quantitative Label-Free Proteomic Analysis of Milk Fat Globule Membrane in Donkey and Human Milk

Relationship between Apolipoprotein Superfamily and Parkinson's Disease

Comparative Whey Proteome Profiling of Donkey Milk With Human and Cow Milk

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