Flavor, Nicotine Content, Vaping Regime, and Lung Region Matter: Alarm Anti-Proteases and Anti-Microbial Defensins Are Important for Electronic Cigarette Related Pulmonary Response

Ganguly, Koustav; Thimraj, Tania A.; Nordström, Axel; Ramström, Malin; Lin, Elizabeth Z.; O’Brien, Fiona; Koelmel, Jeremy P.; Ernstgård, Lena; Johanson, Gunnar; Pollitt, Krystal J. Godri; Palmberg, Lena; Upadhyay, Swapna

doi:10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2768

Cited by 1 publication

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“…Physiologically relevant multicellular bronchial (normal and chronic bronchitis-like) [56] and alveolar mucosa models [57] developed at the air-liquid interface can be used to understand the molecular patho-mechanism of BMS exposure following controlled exposure (acute and repeated) experiments. This would enable realistic exposure experiments in contrast to sub-cultured experiments.…”

Section: Controlled Exposure Experimentsmentioning

confidence: 99%

Clinical, Epidemiological and Experimental Approaches to Assess Adverse Health Outcomes of Indoor Biomass Smoke Exposure: Conclusions from An Indo-Swedish Workshop in Mysuru, January 2020

Anand

Larsson

Johanson

et al. 2020

Toxics

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This report summarizes the outcome of a workshop held in Mysuru, India in January 2020 addressing the adverse health effects of exposure to biomass smoke (BMS). The aim of the workshop was to identify uncertainties and gaps in knowledge and possible methods to address them in the Mysuru study on Determinants of Health in Rural Adults (MUDHRA) cohort. Specific aims were to discuss the possibility to improve and introduce new screening methods for exposure and effect, logistic limitations and other potential obstacles, and plausible strategies to overcome these in future studies. Field visits were included in the workshop prior to discussing these issues. The workshop concluded that multi-disciplinary approaches to perform: (a) indoor and personalized exposure assessment; (b) clinical and epidemiological field studies among children, adolescents, and adults; (c) controlled exposure experiments using physiologically relevant in vitro and in vivo models to understand molecular patho-mechanisms are warranted to dissect BMS-induced adverse health effects. It was perceived that assessment of dietary exposure (like phytochemical index) may serve as an important indicator for understanding potential protective mechanisms. Well trained field teams and close collaboration with the participating hospital were identified as the key requirements to successfully carry out the study objectives.

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Section: Controlled Exposure Experimentsmentioning

confidence: 99%