Flaxseed oligosaccharides alleviate DSS-induced colitis through modulation of gut microbiota and repair of the intestinal barrier in mice

Xu, Zhenxia; Chen, Wenchao; Deng, Qianchun; Huang, Qingde; Wang, Xu; Yang, Czau‐Siung; Huang, Fenghong

doi:10.1039/d0fo01105c

Cited by 67 publications

(42 citation statements)

References 58 publications

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“…During the last twenty years, multiple publications identified a changed composition and metabolism of the gut microbiota associated with increased SCFA concentrations as a possible anti-inflammatory mechanism [ 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 ]. In contrast, high-sugar diet was shown to enhance susceptibility to DSS-colitis via depletion of luminal short chain fatty acids [ 181 ].…”

Section: Short Chain Fatty Acidsmentioning

confidence: 99%

Role of Short Chain Fatty Acids and Apolipoproteins in the Regulation of Eosinophilia-Associated Diseases

Sturm

Knuplez

Marsche

2021

IJMS

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Eosinophils are key components of our host defense and potent effectors in allergic and inflammatory diseases. Once recruited to the inflammatory site, eosinophils release their cytotoxic granule proteins as well as cytokines and lipid mediators, contributing to parasite clearance but also to exacerbation of inflammation and tissue damage. However, eosinophils have recently been shown to play an important homeostatic role in different tissues under steady state. Despite the tremendous progress in the treatment of eosinophilic disorders with the implementation of biologics, there is an unmet need for novel therapies that specifically target the cytotoxic effector functions of eosinophils without completely depleting this multifunctional immune cell type. Recent studies have uncovered several endogenous molecules that decrease eosinophil migration and activation. These include short chain fatty acids (SCFAs) such as butyrate, which are produced in large quantities in the gastrointestinal tract by commensal bacteria and enter the systemic circulation. In addition, high-density lipoprotein-associated anti-inflammatory apolipoproteins have recently been shown to attenuate eosinophil migration and activation. Here, we focus on the anti-pathogenic properties of SCFAs and apolipoproteins on eosinophil effector function and provide insights into the potential use of SCFAs and apolipoproteins (and their mimetics) as effective agents to combat eosinophilic inflammation.

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Section: Short Chain Fatty Acidsmentioning

confidence: 99%

Role of Short Chain Fatty Acids and Apolipoproteins in the Regulation of Eosinophilia-Associated Diseases

Sturm

Knuplez

Marsche

2021

IJMS

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“…Many of them (e.g., Flavonifractor , Enterorhabdus , Desulfovibrio , Elusimicrobium , Roseburia , Candidatus _ Saccharimonas , Anaerovorax , Caproiciproducens , Lachnoclostridium , Ruminiclostridium , Intestinimonas ) play a key role in immunity regulation and intestinal health ( Zhang et al, 2020a ; Zhang et al, 2020b ; Zhao, Jiang & Chu, 2020 ; Ward et al, 2017 ; Zhang et al, 2020a ; Zhang et al, 2020b ). However, Unidentified_Clostridiales , Oscillibacter , Anaerofilum , Parasutterella , Tyzzerella , Blautia , Peptococcus , Mycoplasma , Helicobacter , Butyricimonas have pathogenic and pro-inflammatory effects ( Xu et al, 2020 ; Xue et al, 2020 ; Xie et al, 2020 ). The change in their abundance of these bacteria with age may be a potential reason for the shorter life span (around one year) of Brandt’s voles in the wild.…”

Section: Discussionmentioning

confidence: 99%

Sex- and age-specific variation of gut microbiota in Brandt’s voles

Zhang

2021

PeerJ

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Background Gut microbiota plays a key role in the survival and reproduction of wild animals which rely on microbiota to break down plant compounds for nutrients. As compared to laboratory animals, wild animals face much more threat of environmental changes (e.g. food shortages and risk of infection). Therefore, studying the gut microbiota of wild animals can help us better understand the mechanisms animals use to adapt to their environment. Methods We collected the feces of Brandt’s voles in the grassland, of three age groups (juvenile, adult and old), in both sexes. We studied the gut microbiota by 16S rRNA sequencing. Results The main members of gut microbiota in Brandt’s voles were Firmicutes, Bacteroidetes and Proteobacteria. As voles get older, the proportion of Firmicutes increased gradually, and the proportion of Bacteroides decreased gradually. The diversity of the microbiota of juveniles is lower, seems like there is still a lot of space for colonization, and there are large variations in the composition of the microbiome between individuals. In adulthood, the gut microbiota tends to be stable, and the diversity is highest. In adult, the abundances of Christensenellaceae and Peptococcus of female were significantly higher than male voles. Conclusions The gut microbiota of Brandt’s vole was influenced by sex and age, probably due to growth needs and hormone levels. Gut microbiota of wild animals were much influenced by their life-history reflected by their age and sex. Future studies will be directed to identify functions of these “wild microbiota” in regulating physiological or behavioral processes of wild animals in different life stage or sexes.

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“…Many studies suggested the signatures of micriobial composition and metabolites might be used to predict the action mechanisms of prebiotic or probiotic. 24,[35][36][37][38] The presenting results suggested that FOS supplementation might prevent the DSS-induced dysbiosis of gut microbiota, by increasing the abundance of potentially beneficial bacteria (e.g., Faecalibaculum and Bifidobacterium) and decreasing the abundance of potentially harmful bacteria (e.g., Mucispirillum), but the mechanisms need to be further explored.…”

Section: The Modulation Of Gut Microbiota By Fos Supplementation In Acute Colitis Micementioning

confidence: 95%

Fructooligosaccharide supplementation alleviated the pathological immune response and prevented the impairment of intestinal barrier in DSS-induced acute colitis mice

Liao

Qiu

et al. 2021

Food Funct.

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Flaxseed oligosaccharides alleviate DSS-induced colitis through modulation of gut microbiota and repair of the intestinal barrier in mice

Abstract: Intestinal epithelial barrier dysfunction with dysbiosis of gut microbiota contributes to the occurrence and acceleration of colitis. This study aimed to evaluate the effect of flaxseed oligosaccharides (FOS) on dextran...

Cited by 67 publications

References 58 publications

Role of Short Chain Fatty Acids and Apolipoproteins in the Regulation of Eosinophilia-Associated Diseases

Role of Short Chain Fatty Acids and Apolipoproteins in the Regulation of Eosinophilia-Associated Diseases

Sex- and age-specific variation of gut microbiota in Brandt’s voles

Fructooligosaccharide supplementation alleviated the pathological immune response and prevented the impairment of intestinal barrier in DSS-induced acute colitis mice

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