Fleming’s penicillin producing strain is not Penicillium chrysogenum but P. rubens

Houbraken, Jos; Frisvad, Jens Christian; Samson, Robert A.

doi:10.5598/imafungus.2011.02.01.12

Cited by 218 publications

(165 citation statements)

References 27 publications

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“…Curiously, to date, P. rubens has not shown any link to clinical isolates, although it is a recently resurrected species, closely related to P. chrysogenum (29). In contrast, P. chrysogenum has already been identified as a human pathogen associated with cutaneous and invasive infections (8,30,31).…”

Section: Discussionmentioning

confidence: 99%

Identification and Antifungal Susceptibility of Penicillium-Like Fungi from Clinical Samples in the United States

et al. 2016

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bPenicillium species are some of the most common fungi observed worldwide and have an important economic impact as well as being occasional agents of human and animal mycoses. A total of 118 isolates thought to belong to the genus Penicillium based on morphological features were obtained from the Fungus Testing Laboratory at the University of Texas Health Science Center in San Antonio (United States). The isolates were studied phenotypically using standard growth conditions. Molecular identification was made using two genetic markers, the internal transcribed spacer (ITS) and a fragment of the ␤-tubulin gene. In order to assess phylogenetic relationships, maximum likelihood and Bayesian inference assessments were used. Antifungal susceptibility testing was performed according to CLSI document M38-A2 for nine antifungal drugs. The isolates were identified within three genera, i.e., Penicillium, Talaromyces, and Rasamsonia. The most frequent species in our study were Penicillium rubens, P. citrinum, and Talaromyces amestolkiae. The potent in vitro activity of amphotericin B (AMB) and terbinafine (TRB) and of the echinocandins against Penicillium and Talaromyces species might offer a good therapeutic alternative for the treatment of infections caused by these fungi.

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Section: Discussionmentioning

confidence: 99%

Identification and Antifungal Susceptibility of Penicillium-Like Fungi from Clinical Samples in the United States

et al. 2016

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“…In the present study, we found different Penicillium taxa associated with the Antarctic macroalgae. According to Frisvad and Samson (2004), Scott et al (2004) and Houbraken et al (2011), the taxonomy of the group Penicillium has been regarded to be especially difficult and needs a polyphasic study including physiological, morphological, multilocus sequence typing and chemical methods. For these reasons, the Penicillium sp.…”

Section: Discussionmentioning

confidence: 99%

Diversity and bioprospecting of fungal communities associated with endemic and cold-adapted macroalgae in Antarctica

et al. 2013

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We surveyed the distribution and diversity of fungi associated with eight macroalgae from Antarctica and their capability to produce bioactive compounds. The collections yielded 148 fungal isolates, which were identified using molecular methods as belonging to 21 genera and 50 taxa. The most frequent taxa were Geomyces species (sp.), Penicillium sp. and Metschnikowia australis. Seven fungal isolates associated with the endemic Antarctic macroalgae Monostroma hariotii (Chlorophyte) displayed high internal transcribed spacer sequences similarities with the psychrophilic pathogenic fungus Geomyces destructans. Thirty-three fungal singletons (66%) were identified, representing rare components of the fungal communities. The fungal communities displayed high diversity, richness and dominance indices; however, rarefaction curves indicated that not all of the fungal diversity present was recovered. Penicillium sp. UFMGCB 6034 and Penicillium sp. UFMGCB 6120, recovered from the endemic species Palmaria decipiens (Rhodophyte) and M. hariotii, respectively, yielded extracts with high and selective antifungal and/or trypanocidal activities, in which a preliminary spectral analysis using proton nuclear magnetic resonance spectroscopy indicated the presence of highly functionalised aromatic compounds. These results suggest that the endemic and cold-adapted macroalgae of Antarctica shelter a rich, diversity and complex fungal communities consisting of a few dominant indigenous or mesophilic cold-adapted species, and a large number of rare and/or endemic taxa, which may provide an interesting model of algal-fungal interactions under extreme conditions as well as a potential source of bioactive compounds.

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“…A number of compounds from this genus have been characterised and used for drugs and mycotoxins. For example, the antibiotic penicillin is produced by Penicillium rubens (Houbraken et al 2011), the immunosuppressive drug mycophenolic acid is produced by Penicillium brevicompactum (Regueira et al 2011). There were many new compounds that have been found constantly in the following years with impressive anticancer and antifungal activities (Bladt et al 2013; Kozlovskii et al 2013; Tang et al 2015; Koul et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Chemical diversity from the Tibetan Plateau fungi Penicillium kongii and P. brasilianum

Liu

et al. 2017

Mycology

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Two new secondary metabolites, kongiilines A and B (1, 7), and two asperphenamate derivatives, asperphenamates B and C (5–6), together with 16 known compounds (2–4, 8–20), were isolated from Tibetan Plateau fungi Penicillium kongii and Penicillium brasilianum. This is the first report on asperphenamates B and C as naturally occurring compounds, and that aspterric acid is isolated from P. brasilianum for the first time. Their structures were elucidated by different spectroscopic techniques including high-resolution electrospray ionisation mass spectrum, 1D nuclear magnetic resonance (NMR), and 2D NMR as well as electronic circular dichroism. Compounds 4, 5, and 10 exhibited cytotoxicity activities against human colon carcinoma HCT116 cell line with IC50 values of 88.16, 77.68, and 36.92 μM, respectively. Fungi from Tibetan Plateau represent important and rich resources for the investigation of new chemicals.

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Fleming’s penicillin producing strain is not Penicillium chrysogenum but P. rubens

Cited by 218 publications

References 27 publications

Identification and Antifungal Susceptibility of Penicillium-Like Fungi from Clinical Samples in the United States

Identification and Antifungal Susceptibility of Penicillium-Like Fungi from Clinical Samples in the United States

Diversity and bioprospecting of fungal communities associated with endemic and cold-adapted macroalgae in Antarctica

Chemical diversity from the Tibetan Plateau fungi Penicillium kongii and P. brasilianum

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