Flexible and high heat-resistant stereocomplex PLLA-PEG-PLLA/PDLA blends prepared by melt process: effect of chain extension

Baimark, Yodthong; Pasee, Supasin; Rungseesantivanon, Wuttipong; Prakymoramas, Natcha

doi:10.1007/s10965-019-1881-7

Cited by 19 publications

(16 citation statements)

References 38 publications

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“…Based on XRD patterns, the crystallinity for homocrystallites (HC-X c,XRD ) (eq 1) and stereocomplex crystallites (SC-X c,XRD ) (eq 2) of different blends were calculated. 44 where S hc and S sc are the integrated intensity peaks for homocrystallites and stereocomplex crystallites, respectively. S a is the integrated intensity of the amorphous halo.…”

Section: Methodsmentioning

confidence: 99%

“…The crystalline structures of PLGA/PDLA and PLCL/PDLA blends were evaluated with an X-ray diffractometer (XRD, Rigaku D/max 2500 VB2+/PC) being operated at 40 kV, 200 mA. Based on XRD patterns, the crystallinity for homocrystallites (HC-X c,XRD ) (eq ) and stereocomplex crystallites (SC-X c,XRD ) (eq ) of different blends were calculated where S hc and S sc are the integrated intensity peaks for homocrystallites and stereocomplex crystallites, respectively.…”

Section: Methodsmentioning

confidence: 99%

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Strengthening the Shape Memory Behaviors of l-Lactide-ased Copolymers via Its Stereocomplexation Effect with Poly(d-Lactide)

Wei

Huang

Fang

et al. 2019

Ind. Eng. Chem. Res.

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Biodegradable shape memory polymers (SMPs) have great application prospects in biomedical fields, particularly, those SMPs with the transition temperature of ∼37 °C have attracted keen interests. In this study, poly(d-lactide) (PDLA) of different molecular weights (5000 or 20 000) was introduced into poly(l-lactide-co-glycolide) (PLGA) or poly(l-lactide-co-ε-caprolactone) (PLCL) copolymers at different amounts (5, 10, 15 wt%) to investigate the effect of PLLA/PDLA stereocomplexation (SC-PLA) on the shape memory performance of the blends. The tested copolymers were in different chemical compositions to adjust the lengths of PLLA segments and the glass transition temperatures (T g). Characterizations on crystallization, mechanical properties, shape fixing, and recovery ratios of the blends were conducted, and the results were discussed to correlate the formation of SC-PLA crystals to the shape memory performances of corresponding blends. It was identified that SC-PLA crystals would act as cross-links and had strengthened the stationary phase within the matrixes, which could significantly improve the shape memory performances of PLGA/PDLA and PLCL/PDLA blends if more SC-PLA crystals had formed. Based on the findings, a kind of porous scaffold was prepared using the PLCL(75:25)/PDLA (5k, 10 wt%) blend, which displayed excellent and reproducible compression and recovery behaviors under 37 °C, showing potentials as body temperature triggered SMPs for in vivo applications such as implantable template to facilitate tissue regeneration.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Strengthening the Shape Memory Behaviors of l-Lactide-ased Copolymers via Its Stereocomplexation Effect with Poly(d-Lactide)

Wei

Huang

Fang

et al. 2019

Ind. Eng. Chem. Res.

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“…As shown in the figure, the macromonomerHSEMA-PLLA 25 has the isomorphous peaks at 2θ = 17 • , 19 • and gel4 has a relatively obvious stereocomplex peak at 2θ = 12 • . According to the relevant literature, the synthesis of stereocomplex gel is successful [38]. Figure 4b is the WXRD pattern of the gels with different PLA polymerization degrees.…”

Section: Analysis Of Complex Structurementioning

confidence: 96%

Temperature/Reduction Dual Response Nanogel Is Formed by In Situ Stereocomplexation of Poly (Lactic Acid)

et al. 2021

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A novel type of dual responsive nanogels was synthesized by physical crosslinking of polylactic acid stereocomplexation: temperature and reduction dual stimulation responsive gels were formed in situ by mixing equal amounts of PLA (Poly (Lactic Acid)) enantiomeric graft copolymer micellar solution; the properties of double stimulation response make it more targeted in the field of drug release. The structural composition of the gels was studied by proton nuclear magnetic resonance (1H NMR) and Fourier transform infrared spectroscopy (FT-IR). Using transmission electron microscope (TEM) and dynamic light scattering (DLS) instruments, the differences in morphology and particle size were analyzed (indicating that nanogels have dual stimulus responses of temperature sensitivity and reduction). The Wide-Angle X-ray diffractionr (WAXD) was used to prove the stereocomplexation of PLA in the gels, the mechanical properties and gelation process of the gels were studied by rheology test. The physically cross-linked gel network generated by the self-recombination of micelles and then stereo-complexation has a more stable structure. The results show that the micelle properties, swelling properties and rheological properties of nanogels can be changed by adjusting the degree of polymerization of polylactic acid. In addition, it provides a safe and practical new method for preparing stable temperature/reduction response physical cross-linked gel.

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“…Moreover, PLLA has been combined with more than one polymer to obtain optimal structures that are suitable for specific TE applications. Among them, PLLA/chitosan/collagen constructs [ 111 ], PLGA/PLLA/PDLLA fibers [ 103 ], and PLLA-PEG-PLLA/PDLA blends [ 154 ] were characterized to assess their high performance as biodegradable materials.…”

Section: Plla Hybrid Scaffoldsmentioning

confidence: 99%

Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications

et al. 2022

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Synthetic biopolymers are effective cues to replace damaged tissue in the tissue engineering (TE) field, both for in vitro and in vivo application. Among them, poly-l-lactic acid (PLLA) has been highlighted as a biomaterial with tunable mechanical properties and biodegradability that allows for the fabrication of porous scaffolds with different micro/nanostructures via various approaches. In this review, we discuss the structure of PLLA, its main properties, and the most recent advances in overcoming its hydrophobic, synthetic nature, which limits biological signaling and protein absorption. With this aim, PLLA-based scaffolds can be exposed to surface modification or combined with other biomaterials, such as natural or synthetic polymers and bioceramics. Further, various fabrication technologies, such as phase separation, electrospinning, and 3D printing, of PLLA-based scaffolds are scrutinized along with the in vitro and in vivo applications employed in various tissue repair strategies. Overall, this review focuses on the properties and applications of PLLA in the TE field, finally affording an insight into future directions and challenges to address an effective improvement of scaffold properties.

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Flexible and high heat-resistant stereocomplex PLLA-PEG-PLLA/PDLA blends prepared by melt process: effect of chain extension

Cited by 19 publications

References 38 publications

Strengthening the Shape Memory Behaviors of l-Lactide-ased Copolymers via Its Stereocomplexation Effect with Poly(d-Lactide)

Strengthening the Shape Memory Behaviors of l-Lactide-ased Copolymers via Its Stereocomplexation Effect with Poly(d-Lactide)

Temperature/Reduction Dual Response Nanogel Is Formed by In Situ Stereocomplexation of Poly (Lactic Acid)

Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications

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