Flexible Battery‐Less Bioelectronic Implants: Wireless Powering and Manipulation by Near‐Infrared Light

Li, Hongzhong; Zhao, Tingting; Jiang, Weitao; Jia, Rui; Dong, Ning; Qiu, Guanglin; Lin, Fan; Li, Xin; Liu, Weihua; Chen, Bangdao; Shi, Yongsheng; Yin, Lei; Lu, Bingheng

doi:10.1002/adfm.201502752

Cited by 51 publications

(31 citation statements)

References 40 publications

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“…The minimum coil diameter of the implants demonstrated by Poon et al is 1.6 mm [9]. Other powering methods have been explored, including power transfer by near-infrared light [10], [11] and energy harvesters (e.g. piezoelectric [12] and natural processes of the body such as electric potentials of the inner ear [13]).…”

Section: Introductionmentioning

confidence: 99%

Demonstration of 2 mm Thick Microcontrolled Injectable Stimulators Based on Rectification of High Frequency Current Bursts

Becerra-Fajardo

Schmidbauer

Ivorra

2017

IEEE Trans. Neural Syst. Rehabil. Eng.

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Existing implantable stimulators use powering approaches that result in stiff and bulky systems or result in systems incapable of producing the current magnitudes required for neuromuscular stimulation. This hampers their use in neuroprostheses for paralysis. We previously demonstrated an electrical stimulation method based on electronic rectification of high frequency (HF) current bursts. The implants act as rectifiers of HF current that flows through the tissues by galvanic coupling, transforming this current into low frequency current capable of performing neuromuscular stimulation. Here we developed 2 mm thick, semi-rigid, injectable and addressable stimulators made of off-the-shelf components and based on this method. The devices were tested in vitro to illustrate how they are powered by galvanic coupling. In addition they were tried in an animal model to demonstrate their ability to perform controlled electrical stimulation. The implants were deployed by injection into two antagonist muscles of an anesthetized rabbit and were addressed resulting in independent isometric contractions. Low frequency currents of 2 mA were delivered by the implants. The HF currents are safe in terms of unwanted electrostimulation and tissue heating according to standards. This indicates that the proposed electrical stimulation method will allow unprecedented levels of miniaturization for neuroprostheses.

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Section: Introductionmentioning

confidence: 99%

Demonstration of 2 mm Thick Microcontrolled Injectable Stimulators Based on Rectification of High Frequency Current Bursts

Becerra-Fajardo

Schmidbauer

Ivorra

2017

IEEE Trans. Neural Syst. Rehabil. Eng.

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“…W. Jiang et al. investigated the pyroelectric properties of PVDF and its remote‐manipulation capability with near‐infrared irradiation and designed a wirelessly powered flexible implantable device that can provide regulatable electrical pulses to stimulate biological neural transmissions by infrared irradiation without additional power supply …”

Section: Thermal Energy Harvesting With Pyroelectric Effect and Matermentioning

confidence: 99%

Harvesting Energy from Human Activity: Ferroelectric Energy Harvesters for Portable, Implantable, and Biomedical Electronics

Zhang

et al. 2018

Energy Tech

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Energy harvesters based on ferroelectric materials, which are capable of converting mechanical and thermal energies into electric power, have drawn unprecedented attention in both academic and industrial fields because of their great potential in harvesting human‐activity‐induced and other energies of the human body to drive low‐power, personal, portable, and implantable electronics. Based on previous works that uncovered the features of advanced materials and the nanotechnologies for the fabrication of ferroelectric generators, we emphasize the potential of ferroelectric energy harvesters in biomedical applications, with not only traditional ferroelectrics but also newly developed ferroelectric biomaterials. In addition, the latest representative integration schemes of hybrid generators with ferroelectric materials are outlined, which could markedly extend the functions of energy harvesters, especially for implantable and biomedical applications.

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“…Flexible electronics have captured tremendous attention in recent years due to their potential applications in wearable devices, implanted systems, and brain–machine interfaces, and it is often desired that they possess multiple functionalities, tunable properties, low‐power consumption, as well as mechanical reliability and performance robustness, even under demanding environment. One particular system of extensive interests is flexible ferroelectric field effect transistors (FeFETs), which are capable of both low power sensing and nonvolatile data storage that are attractive for smart wearable devices, and the ability to continuously tune and program their multiple conduction states makes them promising for emerging memristor applications as well, e.g., as artificial synapses in neuromorphic computing .…”

Section: Introductionmentioning

confidence: 99%

Highly Robust Flexible Ferroelectric Field Effect Transistors Operable at High Temperature with Low‐Power Consumption

Ren

Zhong

Xiao

et al. 2019

Adv Funct Materials

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Flexible ferroelectric field effect transistors (FeFETs) with multiple functionalities and tunable properties are attractive for low power sensing, nonvolatile data storage, as well as emerging memristor applications such as artificial synapses, though the state-of-art flexible FeFETs based on organic materials possess low polarization, large coercivity, and high operating voltage, and suffer from poor thermal stability. Here, developed is an all-inorganic flexible FeFET based on epitaxial Pb(Zr 0.1 Ti 0.9 )O 3 /ZnO heterostructure on a mica substrate, which not only operates under a small voltage (±6 V) and thus consumes low power with an excellent on/off ratio of 10 4 as well as retention characteristics, but also shows robust FeFET performance under large bending deformation (4 mm), extended bending cycling (500 cycles), and high temperature operation at 200 °C. Importantly, the FeFET characteristics depend on temperature, but not on temperature history, critical for operation under repeated thermal loading. The excellent mechanical flexibility and functional robustness of the flexible FeFET originate from the unique van der Waals bonded layer structure of mica, facilitating a small bending radius yet modest strain. This work demonstrates the great promise of mica as a universal platform to integrate complicated functional devices for flexible electronics, especially under harsh environment.

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Flexible Battery‐Less Bioelectronic Implants: Wireless Powering and Manipulation by Near‐Infrared Light

Cited by 51 publications

References 40 publications

Demonstration of 2 mm Thick Microcontrolled Injectable Stimulators Based on Rectification of High Frequency Current Bursts

Demonstration of 2 mm Thick Microcontrolled Injectable Stimulators Based on Rectification of High Frequency Current Bursts

Harvesting Energy from Human Activity: Ferroelectric Energy Harvesters for Portable, Implantable, and Biomedical Electronics

Highly Robust Flexible Ferroelectric Field Effect Transistors Operable at High Temperature with Low‐Power Consumption

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