Flexible Implementation of the BASIL CURE

Roberts, Rebecca; Hall, Bonnie L.; Daubner, Colette; Goodman, Anya; Pikaart, Michael J.; Sikora, Arthur; Craig, P.

doi:10.1002/bmb.21287

Cited by 19 publications

(37 citation statements)

References 26 publications

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“…A recent article by Bell et al suggested the need for CUREs that focus on protein biochemistry 19 . Two such CUREs were mentioned at the IUBMB Education Conference 2019: the Malate Dehydrogenase CURE Community (http://home.sandiego.edu/~josephprovost/MCC.html) and BASIL, 20 a project involving the author and faculty members on 14 campuses.…”

Section: Figurementioning

confidence: 99%

“…BASIL (Biochemistry Authentic Scientific Inquiry Lab) is a CURE where students focus on predicting protein function, 20 using in silico (sequence alignment, structure alignment, and docking) and in vitro approaches (protein expression, purification, quantitation, SDS‐PAGE, enzyme activity and kinetics) to explore individual protein structures (Figure 1). Some methods are well established, but even simple methods have potential pitfalls.…”

Section: Figurementioning

confidence: 99%

“…The in silico and in vitro path for protein function prediction in the BASIL Curriculum (used with permission from Reference 20)…”

Section: Figurementioning

confidence: 99%

“…19 Two such CUREs were mentioned at the IUBMB Education Conference 2019: the Malate Dehydrogenase CURE Community (http://home.sandiego.edu/~josephprovost/ MCC.html) and BASIL, 20 a project involving the author and faculty members on 14 campuses. BASIL (Biochemistry Authentic Scientific Inquiry Lab) is a CURE where students focus on predicting protein function, 20 using in silico (sequence alignment, structure alignment, and docking) and in vitro approaches (protein expression, purification, quantitation, SDS-PAGE, enzyme activity and kinetics) to explore individual protein structures (Figure 1). Some methods are well established, but even simple methods have potential pitfalls.…”

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confidence: 99%

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Something old, something new: Teaching the BMB lab

Craig

2020

Biochem Molecular Bio Educ

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Lab courses are a significant component of biochemistry and molecular biology (BMB) education. In teaching the labs, we combine established techniques with novel approaches. Lab formats have also moved from traditional cookbook style labs to guided inquiry to course-based undergraduate research experiences (CUREs), where faculty bring their own research interests into the course setting with a larger number of students in a much more restricted time frame. This presentation is designed to explore some of these ideas and challenge the reader to introduce research opportunities to all students, not just the smaller group of students in their research labs. K E Y W O R D S computational biology, computers in research and teaching, enzymes and catalysis, genomics proteomics bioinformatics, integration of research into undergraduate teaching, laboratory exercises, molecular visualization, new course development

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Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

“…The in silico and in vitro path for protein function prediction in the BASIL Curriculum (used with permission from Reference 20)…”

Section: Figurementioning

confidence: 99%

mentioning

confidence: 99%

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Something old, something new: Teaching the BMB lab

Craig

2020

Biochem Molecular Bio Educ

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“…The camp was designed and directed by members from the IQB and the RCSB Protein Data Bank, facilitated by nine mentors from Rutgers and six mentors associated with the BASIL Consortium (https://basilbiochem.github.io/basil/index.html 6 ). Student researchers were selected from the RISE program at Rutgers (https://www.rise.rutgers.edu/), from other Rutgers‐affiliated programs, and from the campuses of the BASIL mentors.…”

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confidence: 99%

Virtual Boot Camp: COVID‐19 evolution and structural biology

Burley

Bromberg

Craig

et al. 2020

Biochem Molecular Bio Educ

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PDB‐101: Educational resources supporting molecular explorations through biology and medicine

et al. 2021

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The Protein Data Bank (PDB) archive is a rich source of information in the form of atomic‐level three‐dimensional (3D) structures of biomolecules experimentally determined using macromolecular crystallography, nuclear magnetic resonance (NMR) spectroscopy, and electron microscopy (3DEM). Originally established in 1971 as a resource for protein crystallographers to freely exchange data, today PDB data drive research and education across scientific disciplines. In 2011, the online portal PDB‐101 was launched to support teachers, students, and the general public in PDB archive exploration (http://pdb101.rcsb.org). Maintained by the Research Collaboratory for Structural Bioinformatics PDB, PDB‐101 aims to help train the next generation of PDB users and to promote the overall importance of structural biology and protein science to nonexperts. Regularly published features include the highly popular Molecule of the Month series, 3D model activities, molecular animation videos, and educational curricula. Materials are organized into various categories (Health and Disease, Molecules of Life, Biotech and Nanotech, and Structures and Structure Determination) and searchable by keyword. A biennial health focus frames new resource creation and provides topics for annual video challenges for high school students. Web analytics document that PDB‐101 materials relating to fundamental topics (e.g., hemoglobin, catalase) are highly accessed year‐on‐year. In addition, PDB‐101 materials created in response to topical health matters (e.g., Zika, measles, coronavirus) are well received. PDB‐101 shows how learning about the diverse shapes and functions of PDB structures promotes understanding of all aspects of biology, from the central dogma of biology to health and disease to biological energy.

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Flexible Implementation of the BASIL CURE

Cited by 19 publications

References 26 publications

Something old, something new: Teaching the BMB lab

Something old, something new: Teaching the BMB lab

Virtual Boot Camp: COVID‐19 evolution and structural biology

PDB‐101: Educational resources supporting molecular explorations through biology and medicine

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