Flexible Imputation of Missing Data

Buuren, Stef van

doi:10.1201/b11826

Cited by 1,794 publications

(1,650 citation statements)

References 0 publications

Supporting

Mentioning

1,606

Contrasting

Unclassified

Order By: Relevance

“…In addition to including all model 4 covariates, the imputation model included the event indicator and the NelsonAalen estimator of the cumulative marginal hazard H(T), where T is the time to event or censoring (9). Imputations were performed separately by year of ESRD therapy initiation and assumed a joint modeling approach (10). Log HR from the models applied to each imputation dataset were then combined, as described by Little and Rubin (11).…”

Section: Statistical Analysesmentioning

confidence: 99%

Patient Characteristics and Outcomes by GN Subtype in ESRD

O’Shaughnessy

Montez‐Rath

Lafayette

et al. 2015

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Background and objectives Outcomes-based research rarely focuses on patients with ESRD caused by GN. The hypotheses were that the GN subtype would clinically discriminate patient groups and independently associate with survival after ESRD therapy initiation.Design, setting, participants, & measurements Data were extracted from the US Renal Data System for adult patients with incident (1996-2011) ESRD attributed to six GN subtypes: FSGS, IgA nephropathy (IgAN), membranous nephropathy, membranoproliferative glomeruonephritis, lupus nephritis (LN), and vasculitis. ESRD attributed to diabetes and autosomal dominant polycystic kidney disease served as non-GN comparators. Unadjusted and adjusted mortality hazard ratios (aHRs) with 95% confidence intervals (95% CIs) were estimated using Cox regression (reference, IgAN). Models sequentially adjusted for sociodemographic (model 2), comorbidity/laboratory (model 3), and ESRD treatment modality (model 4) variables.Results Among 84,301 patients with ESRD attributed to GN, the median age ranged from 39 (LN) to 66 (vasculitis) years, male sex ranged from 18% (LN) to 68% (IgAN), and black race ranged from 7% (IgAN) to 49% (LN). Patients with IgAN had the fewest comorbidities and lowest use of hemodialysis (70.1%). After a median followup of 2.5 (interquartile range, 1.0-4.9) years, crude mortality was lowest in IgAN (3.7 deaths/100 person years). Compared to IgAN, adjusted mortality was highest in LN (model 4 aHR=1.75; 95% CI, 1.68 to 1.83) and in diabetes (aHR=1.73; 95% CI, 1.67 to 1.79), and was also higher in all other GN subtypes (membranous nephropathy: aHR=1.23; 95% CI, 1.17 to 1.29; FSGS: aHR=1.37; 95% CI, 1.32 to 1.42; membranoproliferative GN: aHR=1.38; 95% CI, 1.31 to 1.45; vasculitis: aHR=1.51; 95% CI, 1.45 to 1.58) and in autosomal dominant polycystic kidney disease (aHR=1.22; 95% CI, 1.18 to 1.27).Conclusions This study exposes substantial heterogeneity across GN subtypes at ESRD therapy initiation and identifies independent associations between GN subtype and post-ESRD mortality. These survival discrepancies warrant further study, and the utility of current research practice to group GN subtypes together when evaluating ESRD outcomes should be questioned.

show abstract

Section: Statistical Analysesmentioning

confidence: 99%

Patient Characteristics and Outcomes by GN Subtype in ESRD

O’Shaughnessy

Montez‐Rath

Lafayette

et al. 2015

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

show abstract

“…The distributions for child and parental educational levels and for geographical regions were compared with the national distributions (31) to check for representativeness. We used the multivariate imputation by chained equation method (32,33) to correct for educational levels or geographical regions that were underrepresented. The imputation model was based on age, sex, height SDS, weight SDS, waist SDS, hip SDS, parental height, birth weight, ethnicity, socioeconomic status score (34), educational levels of the children and parents, and geographical region.…”

Section: Statistical Analysesmentioning

confidence: 99%

The world’s tallest nation has stopped growing taller: the height of Dutch children from 1955 to 2009

et al. 2012

Self Cite

View full text Add to dashboard Cite

“…Also, multiple ratio imputation is not limited to the EMB algorithm. Depending on the nature of imputation, multiple ratio imputation may be implemented by way of other multiple imputation algorithms, such as MCMC and Fully Conditional Specification (FCS) (van Buuren, 2012). reg An option to perform regression analysis.…”

Section: Resultsmentioning

confidence: 99%