Flexible pressure sensors that can maintain their pressure sensing ability with arbitrary deformation play an essential role in a wide range of applications, such as aerospace, prosthetics, robotics, healthcare, human–machine interfaces, and electronic skin. Flexible pressure sensors with diverse conversion principles and structural designs have been extensively studied. At present, with the development of 5G and the Internet of Things, there is a huge demand for flexible pressure sensor arrays with high resolution and sensitivity. Herein, we present a brief description of the present flexible pressure sensor arrays with different transduction mechanisms from design to fabrication. Next, we discuss the latest progress of flexible pressure sensor arrays for applications in human–machine interfaces, healthcare, and aerospace. These arrays can monitor the spatial pressure and map the trajectory with high resolution and rapid response beyond human perception. Finally, the outlook of the future and the existing problems of pressure sensor arrays are presented.