Flexible wound healing system for pro-regeneration, temperature monitoring and infection early warning

Lou, Dong; Pang, Qian; Pei, Xiachuan; Dong, Shurong; Li, Shijian; Tan, Wei‐Qiang; Ma, Lie

doi:10.1016/j.bios.2020.112275

Cited by 79 publications

(73 citation statements)

References 33 publications

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“…Therefore, monitoring the subtle temperature changes at the wound is quite necessary for ideal wound healing [ 188 ]. To eliminate the "black box" state in the wound healing process and grasp the wound's situation in real-time, Lou et al [ 189 ] proposed a transparent and soft, closed-loop wound healing system to promote wound healing real-time monitoring of the wound. The flexible wound healing system (FWHS) and flexible wound temperature sensing device (FWTSD) likes the form of band-aids, their flexible device in the shape of a double-layered band-aid can be directly attached to the wound.…”

Section: Resultsmentioning

confidence: 99%

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Printable, Highly Sensitive Flexible Temperature Sensors for Human Body Temperature Monitoring: A Review

Chen

et al. 2020

Nanoscale Res Lett

169

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In recent years, the development and research of flexible sensors have gradually deepened, and the performance of wearable, flexible devices for monitoring body temperature has also improved. For the human body, body temperature changes reflect much information about human health, and abnormal body temperature changes usually indicate poor health. Although body temperature is independent of the environment, the body surface temperature is easily affected by the surrounding environment, bringing challenges to body temperature monitoring equipment. To achieve real-time and sensitive detection of various parts temperature of the human body, researchers have developed many different types of high-sensitivity flexible temperature sensors, perfecting the function of electronic skin, and also proposed many practical applications. This article reviews the current research status of highly sensitive patterned flexible temperature sensors used to monitor body temperature changes. First, commonly used substrates and active materials for flexible temperature sensors have been summarized. Second, patterned fabricating methods and processes of flexible temperature sensors are introduced. Then, flexible temperature sensing performance are comprehensively discussed, including temperature measurement range, sensitivity, response time, temperature resolution. Finally, the application of flexible temperature sensors based on highly delicate patterning are demonstrated, and the future challenges of flexible temperature sensors have prospected.

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Section: Resultsmentioning

confidence: 99%

“…The FWTSD with a Band-Aid shape tightly contacts with the wound site. Temperature variation is detected by temperature sensor [189]. c Optical image of a multifunctional balloon catheter in deflated and inflated states [191].…”

Section: Applicationsmentioning

confidence: 99%

Printable, Highly Sensitive Flexible Temperature Sensors for Human Body Temperature Monitoring: A Review

Chen

et al. 2020

Nanoscale Res Lett

169

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“…Lastly, the TCR variance of 46 sensors from a single batch was below 2%. Based on the high linearity and constant TCR values, we conclude that the microfabricated sensors, with ±0.2 °C accuracy, are suitable for precise temperature monitoring for detecting inflammation, which is expected to increase gradually by 1.5 to 4 °C and remain for several days [ 20 , 36 , 37 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…In addition to chemical and biological changes, temperature is a targeting parameter that correlates with inflammation. In fact, various types of temperature sensors and fully implantable or wearable supporting systems have been developed and successfully applied for monitoring in various organs such as cardiac tissue [ 16 ], abdomen [ 17 ], intracranial surface [ 18 ], and skin [ 19 , 20 ]. For oral diagnostics, a periodontal temperature probe has been developed for detecting small temperature changes on localized periodontal sites [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Development of a Dental Implantable Temperature Sensor for Real-Time Diagnosis of Infectious Disease

Kim

Stafford

Beauchamp

et al. 2020

Sensors

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Implantable sensors capable of real-time measurements are powerful tools to diagnose disease and maintain health by providing continuous or regular biometric monitoring. In this paper, we present a dental implantable temperature sensor that can send early warning signals in real time before the implant fails. Using a microfabrication process on a flexible polyimide film, we successfully fabricated a multi-channel temperature sensor that can be wrapped around a dental implant abutment wing. In addition, the feasibility, durability, and implantability of the sensor were investigated. First, high linearity and repeatability between electrical resistance and temperature confirmed the feasibility of the sensor with a temperature coefficient of resistance (TCR) value of 3.33 × 10–3/°C between 20 and 100 °C. Second, constant TCR values and robust optical images without damage validated sufficient thermal, chemical, and mechanical durability in the sensor’s performance and structures. Lastly, the elastic response of the sensor’s flexible substrate film to thermal and humidity variations, simulating in the oral environment, suggested its successful long-term implantability. Based on these findings, we have successfully developed a polymer-based flexible temperature sensor for dental implant systems.

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“…The sensor testing method was carried out as described in a previous study (Lou et al ., 2020). Briefly, the sensor chip was placed in a constant temperature shaker (LYZ‐100B; Longyue, Shanghai, China), and the temperature was gradually increased.…”

Section: Methodsmentioning

confidence: 99%

Flexible integrated sensing platform for monitoring wound temperature and predicting infection

Zhang¹,

Lin²,

Huang³

et al. 2021

Microbial Biotechnology

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Wound infection is a challenging clinical problem that imposes substantial economic and psychological burdens on patients. However, the wound covered by a dressing is in an 'unknown' state. Recently, researchers have focused on understanding the condition of the wound without removing the dressing. Here, we presented a flexible integrated sensing platform (FISP) that can monitor multiple indicators, including local temperature. The platform consists of a flexible sensor chip (FSC), a controlled printed circuit board (CPCB) and a customized application installed on a smartphone that can receive and display data from the sensor chip through Bluetooth Low Energy 4.0 (BLE4.0) and upload real-time wound information. This device exhibits satisfactory measurement accuracy, stability, durability, skin compliance and biocompatibility. It was applied to infected wounds on the back of rabbits to reveal the temperature changes characteristic of wounds infected with different bacteria, and this information was compared with the changes in the core body temperature of animals. We found differences in the temperature among wounds infected with different pathogens and the temperature of the wound infection occurred earlier than the change in anal temperature. The combined application of the FISP and dressings might help identify the 'unknown' state of wounds in the clinic.

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Flexible wound healing system for pro-regeneration, temperature monitoring and infection early warning

Cited by 79 publications

References 33 publications

Printable, Highly Sensitive Flexible Temperature Sensors for Human Body Temperature Monitoring: A Review

Printable, Highly Sensitive Flexible Temperature Sensors for Human Body Temperature Monitoring: A Review

Development of a Dental Implantable Temperature Sensor for Real-Time Diagnosis of Infectious Disease

Flexible integrated sensing platform for monitoring wound temperature and predicting infection

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