2013
DOI: 10.1002/mus.23796
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Flexor hallucis brevis spasm

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“…These approaches and their practical utility in patient-specific hiPSCs have been recently reviewed elsewhere (Hendriks et al 2016 ). Genome editing technologies are particularly relevant to monogenic diseases rather than complex genetic disorders or sporadic disease (Shribman et al 2013 ; Samani et al 2015 ; Patani et al 2013 ; Athappily et al 2013 ). An ideal approach for mendelian disorders is to generate reciprocal isogenic lines for a given mutation being studied—i.e., the mutation is corrected to create one isogenic pair, and it is separately inserted into a control line to generate a second isogenic pair (Liu et al 2012 ).…”
Section: Genomic Variation Between Hipsc Linesmentioning
confidence: 99%
“…These approaches and their practical utility in patient-specific hiPSCs have been recently reviewed elsewhere (Hendriks et al 2016 ). Genome editing technologies are particularly relevant to monogenic diseases rather than complex genetic disorders or sporadic disease (Shribman et al 2013 ; Samani et al 2015 ; Patani et al 2013 ; Athappily et al 2013 ). An ideal approach for mendelian disorders is to generate reciprocal isogenic lines for a given mutation being studied—i.e., the mutation is corrected to create one isogenic pair, and it is separately inserted into a control line to generate a second isogenic pair (Liu et al 2012 ).…”
Section: Genomic Variation Between Hipsc Linesmentioning
confidence: 99%