Flexural strength, biocompatibility, and antimicrobial activity of a polymethyl methacrylate denture resin enhanced with graphene and silver nanoparticles

Nanotechnology has recently emerged as a rapidly growing field with numerous biomedical science applications. At the same time, silver has been adopted as an antimicrobial material and disinfectant that is relatively free of adverse effects. Silver nanoparticles possess a broad spectrum of antibacterial, antifungal and antiviral properties. Silver nanoparticles have the ability to penetrate bacterial cell walls, changing the structure of cell membranes and even resulting in cell death. Their efficacy is due not only to their nanoscale size but also to their large ratio of surface area to volume. They can increase the permeability of cell membranes, produce reactive oxygen species, and interrupt replication of deoxyribonucleic acid by releasing silver ions. Researchers have studied silver nanoparticles as antimicrobial agents in dentistry. For instance, silver nanoparticles can be incorporated into acrylic resins for fabrication of removable dentures in prosthetic treatment, composite resin in restorative treatment, irrigating solution and obturation material in endodontic treatment, adhesive materials in orthodontic treatment, membrane for guided tissue regeneration in periodontal treatment, and titanium coating in dental implant treatment. Although not all authorities have acknowledged the safety of silver nanoparticles, no systemic toxicity of ingested silver nanoparticles has been reported. A broad concern is their potential hazard if they are released into the environment. However, the interaction of nanoparticles with toxic materials and organic compounds can either increase or reduce their toxicity. This paper provides an overview of the antibacterial use of silver nanoparticles in dentistry, highlighting their antibacterial mechanism, potential applications and safety in clinical treatment.

show abstract

“…Moreover, they can increase the thermal conductivity and compressive strength of the acrylic base. 24…”

Section: Prosthetic Treatmentmentioning

confidence: 99%

<p>The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry</p>

Yin¹,

Zhang²,

Zhao³

et al. 2020

IJN

1,208

681

View full text Add to dashboard Cite

show abstract

“…Bacali et al [ 38 ] evaluated some clinical and chemo-physical features of modified denture resins. The authors evaluated the feature of auto-polymerizing acrylic resin loaded with 1% and 2% of G-AgNp (graphene–Ag nanoparticles).…”

Section: Resultsmentioning

confidence: 99%

“…According to Bacali et al [ 38 ], PMMA resin loaded with G-AgNp promise good antibacterial properties. Alfaifi et al [ 39 ] affirmed that nicotine and caffeine could affect metabolic activity and biofilm formation of C. albicans .…”

Section: Discussionmentioning

confidence: 99%

“…According to Bacali et al [ 38 ], PMMA resin loaded with G-AgNp caused minimal toxicity to human cells in vitro. Lee et al [ 42 ] evaluated different resin denture materials’ cytotoxicity.…”

Section: Discussionmentioning

confidence: 99%

“…Flexural strength result improved in PMMA resin loaded with G-AgNp [ 38 ]. Al-Thobity et al [ 40 ] in their study, showed how different cleansing solutions could modify denture resin properties.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Biological and Chemo-Physical Features of Denture Resins

et al. 2020

View full text Add to dashboard Cite

In the dental field, the study of materials has always been the basis of the clinical practice. Over the years, with the evolution of materials, it has been possible to produce safe and predictable prosthetic devices, with ever better aesthetic features, biocompatibility and patient satisfaction. This review briefly analyzes the features of dental resin materials to underline the biological, microbiological and chemo-physical characteristics. The main aim of prosthodontics is to rehabilitate patients and therefore improve their quality of life. Dental resins are the main materials used for the production of dentures. Once solidified, these polymers have different mechanical or surface characteristics. The results of the literature on these characteristics were analyzed and some new brand dental resins, known as modern resin, were subsequently evaluated. The new materials are undoubtedly a step forward in the creation of dental prostheses, and also in all subsequent maintenance phases. This review shows how changing the chemical structure of the resins could have microbiological influences on the growth and management of the biofilm, and also physical influences in terms of its mechanical characteristics. The development of new materials is a constant goal in dentistry in order to obtain increasingly predictable rehabilitations.

show abstract

Functionalization of PMMA/TiO₂ nanocomposites: Synthesis, characterization and their antioxidant and antibacterial evaluation

Singh

Mirza

Mondal

et al. 2021

J of Applied Polymer Sci

View full text Add to dashboard Cite

The present work reports the functionalization of PMMA and its nanocomposites were synthesized via simple solution mixing method. Functionalization of PMMA with different amino containing groups, that is, ethylene diamine (ED) and 4‐amino benzoic acid (PA) and used with low dosage (1 wt% and 3 wt%) of TiO2 nanoparticles (NPs) to form nanocomposites. The morphology was determined by SEM, average particle size (50 nm) of TiO2 NPs was measured by TEM. The pore radius (14.47 A°) and specific surface area (157.89 m2/g) of TiO2 NPs were measured by BET analysis. FT‐IR and NMR analysis confirms the functionalization of PMMA. The antioxidant activity of functionalized PMMA and its nanocomposites have been analyzed by using 2,2 diphenyl‐1‐picryhydrazyl (DPPH) assay. The antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) of functionalized polymer nanocomposites were investigated. The result revealed that functionalized PMMA (PMPA) shows maximum antioxidant activity. The increase in concentration of TiO2 NPs efficiently augments the bacterial inhibition against Gram‐negative and Gram‐positive bacteria. The maximum zone of inhibition (ZOI) was recorded against E. coli ATCC 25922 (30 mm) and S. aureus ATCC 29213 (31 mm) and minimum inhibitory concentration (MIC) over E. coli (64 μg/ml) and S. aureus (32 μg/ml) by PMPA2. The synthesized functionalized PMMA nanocomposites can be considered as promising material for biological applications.

show abstract

Flexural strength, biocompatibility, and antimicrobial activity of a polymethyl methacrylate denture resin enhanced with graphene and silver nanoparticles

Cited by 83 publications

References 64 publications

<p>The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry</p>

<p>The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry</p>

Biological and Chemo-Physical Features of Denture Resins

Functionalization of PMMA/TiO₂ nanocomposites: Synthesis, characterization and their antioxidant and antibacterial evaluation

Contact Info

Product

Resources

About

Flexural strength, biocompatibility, and antimicrobial activity of a polymethyl methacrylate denture resin enhanced with graphene and silver nanoparticles

Cited by 83 publications

References 64 publications

<p>The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry</p>

<p>The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry</p>

Biological and Chemo-Physical Features of Denture Resins

Functionalization of PMMA/TiO2 nanocomposites: Synthesis, characterization and their antioxidant and antibacterial evaluation

Contact Info

Product

Resources

About

Functionalization of PMMA/TiO₂ nanocomposites: Synthesis, characterization and their antioxidant and antibacterial evaluation