Flinders sensitive line rats are resistant to infarction following transient occlusion of the middle cerebral artery

Bay, Vibeke; Happ, Denise F.; Ardalan, Maryam; Quist, Alexandra; Oggiano, Florian; Chumak, Tetyana; Hansen, Karl B.; Ding, Ming; Mallard, Carina; Tasker, R. Andrew; Wegener, Gregers

doi:10.1016/j.brainres.2020.146797

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…Thus, the genetic strains of laboratory rats simulating human patholo gies have been developed: for example, the Zucker strain for human obesity, hypertension, type II diabetes and heart disease (Schmidt, 2002); the reelin-deficient shaking rat Kawasaki for schizophrenia and autism (Aikawa et al, 1988); and the Brattleboro strain for hypothalamic diabetes insipidus (Ideno et al, 2003). To date, there are about 1,000 inbred strains of laboratory rats developed by genetic breeding that have "fixed" alleles for natural diseases (Greenhouse et al, 1990), such as mental disorders (Taylor et al, 2002), depression (Bay et al, 2020) and chronic renal failure (Zhang H.F. et al, 2019). The Wistar and SpragueDawley strains are the most commonly used laboratory rats (Sengupta, 2013).…”

Section: Introductionmentioning

confidence: 99%

RatDEGdb: a knowledge base of differentially expressed genes in the rat as a model object in biomedical research

Chadaeva,

Filonov,

Zolotareva

et al. 2023

Vestn. VOGiS

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The animal models used in biomedical research cover virtually every human disease. RatDEGdb, a knowledge base of the differentially expressed genes (DEGs) of the rat as a model object in biomedical research is a collection of published data on gene expression in rat strains simulating arterial hypertension, age-related diseases, psychopathological conditions and other human afflictions. The current release contains information on 25,101 DEGs representing 14,320 unique rat genes that change transcription levels in 21 tissues of 10 genetic rat strains used as models of 11 human diseases based on 45 original scientific papers. RatDEGdb is novel in that, unlike any other biomedical database, it offers the manually curated annotations of DEGs in model rats with the use of independent clinical data on equal changes in the expression of homologous genes revealed in people with pathologies. The rat DEGs put in RatDEGdb were annotated with equal changes in the expression of their human homologs in affected people. In its current release, RatDEGdb contains 94,873 such annotations for 321 human genes in 836 diseases based on 959 original scientific papers found in the current PubMed. RatDEGdb may be interesting first of all to human geneticists, molecular biologists, clinical physicians, genetic advisors as well as experts in biopharmaceutics, bioinformatics and personalized genomics. RatDEGdb is publicly available at https://www.sysbio.ru/RatDEGdb.

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