Flip--an Ibm-704 Code to Solve the Pl and Double-Pl Equations in Slab Geometry

Abstract

This document is an interim memorandum prepared primarily for internal reference and does not represent a final expression of the opinion of Westinghouse. When this memorandum is distributed externally, it is with the express understanding that Westinghouse makes no representation as to completeness, accuracy, or usability of information' contnincd therein.

Enzymatic Assay for Rapid Measurement of Antiretroviral Drug Levels

“…Serial dilutions of TFV-DP in buffer spanning a concentration range of 1 -10,000 nM were prepared to span two orders of magnitude above and below the clinically relevant range for adherence measurement as described in pharmacokinetic studies. 19,41 RESTRICT assay optimization experiments were completed at 100, 300, 1560, and 6250 nM dNTP concentration.…”

“…The RESTRICT assay could provide information on antiretroviral drug levels prior to treatment failure and thus could be a useful and objective tool for monitoring long-term adherence to ART and PrEP in clinical practice and implementation studies. For example, the RESTRICT assay could be used to identify patients with low antiretroviral drug levels (< 2 doses per week) 29,41 who are at risk of treatment failure. Objective measures of ART adherence could be used to compare the effectiveness of behavioral interventions designed to improve medication adherence and HIV treatment and prevention outcomes.…”

“…Building on recent reports of the accumulation of TFV-DP in red blood cells (RBCs) and pharmacokinetic data about drug levels corresponding to ART and PrEP adherence, 19,41,42 we designed the RESTRICT assay to measure antiretroviral drug levels in RBCs with whole blood dilution as a simple sample preparation strategy. We developed and optimized the RESTRICT assay using designer single-stranded DNA templates, primers, and intercalating fluorescence dyes to measure TFV-DP spiked in buffer and blood at clinically relevant concentrations.…”

A modular nodal method for solving the neutron transport equation using spherical harmonics in two dimensions

“…Along with the developments at the theoretical front, the practical applications also began to surface in the form of the computer codes. One of the earlier codes, which solved the Pn and double Pn equations in slab geometry, was reported by B. Anderson [9]. Another computer code for two dimensional Cartesian geometry for the third order approximation was developed by E. Gelbard in 1962 [10].…”