We read with great interest the case report by Hisagi and associates. 1 We congratulate them on their excellent result. We thoroughly agree with their prompt and aggressive workup, including transesophageal echocardiography, to detect a source of embolism.There are several points to be discussed. First, we believe that the context may be misunderstood. They commented that the neurological event was suspected to be a transient ischemic attack, not a stroke/cerebral hemorrhage, which was confi rmed by magnetic resonance imaging. Therefore, the last sentence of the discussion is not consistent with their position.Second, the timing of the operation is a matter of concern. The operation was performed 5 days after admission despite evidence of splenic embolization during the clinical course. 1 Even though the size of the thrombus was getting smaller with anticoagulation, we believe that surgery should have been performed earlier. Some previous reports have shown catastrophic consequences of a fl oating thrombus in the ascending aorta, such as acute myocardial infarct (AMI) and cerebrovascular accident (CVA). 2-4 In reviewing those 12 reports, a fl oating thrombus in the ascending aorta had been associated with three AMIs (25%), three CVAs (25%), three peripheral embolisms (25%), and two visceral embolisms (17%) including one fatal superior mesenteric artery embolism. [2][3][4] We strongly suggest surgical removal of the fl oating thrombus in the ascending aorta as soon as possible when no contraindication for cardiopulmonary bypass exists, such as a cerebral infarct or hemorrhage (or both) and lethal liver dysfunction. To avoid the worst scenario, one should not procrastinate about surgery for this entity.Recently we encountered a case similar to that presented by Hisagi et al. The patient was a 62-year-old man transferred to our hospital with a shock vital due to AMI. Computed tomography showed a thrombus on the ascending aorta (Fig. 1), and coronary angiography revealed occlusion of the left main coronary trunk. Recanalization of the artery was accomplished while waiting for emergency surgery. A thrombus measuring 40 × 20 mm was attached to the left Valsalva sinus and extended to the proximal ascending aorta without a stalk. It was easily removed, and a stent placed at the left main trunk was confi rmed. The aortic valve, Valsalva sinus, and the ascending aorta were macroscopically normal. Coronary artery bypass grafting was performed concomitantly. The patient expired 5 days after the operation from low cardiac output syndrome.