Floor Pen Studies on the Anticoccidial Efficacy of Arprinocid in Turkeys

Abstract

Arprinocid was tested against coccidiosis in turkeys reared in floor pens. Contamination of pens with Eimeria meleagrimitis, E. adenoeides, and E. gallopavonis was accomplished by the infected seeder bird technique. Performance improved with increasing levels of arprinocid through 120 ppm, but weight gains were depressed at 180 ppm. Lesion scores were significantly and progressively reduced by treatment with 60, 90, 120, and 180 ppm of arprinocid. Control of lesion scores and performance of birds treated with 120 ppm of arprinocid were comparable to the amprolium (125 ppm) treatment. In a separate experiment, the oocyst passage of E. meleagrimitis and of E. adenoeides was progressively reduced by increasing levels of arprinocid, and sporulation rate was decreased. Sportulation was not obtained in oocysts from birds fed arprinocid at 120 ppm or higher.

The interactions between drugs and the parasite surface

“…Arprinocid, 9-(2-chloro-6-fluorobenzyl) adenine, is an effective anticoccidial drug (Miller, McManus, Olson, Schleim, Van Iderstine, Graham, Brown & Rogers, 1977;McDougald & Johnson, 1979;Wang, 1982). Good control of coccidiosis can be achieved by oral administration of either arprinocid or arprinocid-1-iV-oxide.…”

Coccidiosis in the turkey

“…Other synthetic drugs shown to have anticoccidial activity in turkeys include arprinocid (McDougald & Johnson, 1979), buquinolate (Edgar & Flanagan, 1968), clopidol (Joyner & Norton, 1970), decoquinate (Joyner & Norton, 1970), diclazuril (Vanparijs et al, 1989a,b), ethopabate (Joyner & Norton, 1973), halofuginone (Ross, 1974), nicarbazin (Ott et al, 1956), robenidine (Joyner & Norton, 1972), toltrazuril (Greuel et al, 1991), and zoalene (Hymas & Stevenson, 1962). Nicarbazin has activity against E. gallopavonis and E. meleagrimitis but is 8 to 16 times less potent than sulfaquinoxaline (Ott et al, 1956).…”

Συμβολη Στη Μελετη Της Παρασιτικης Πανιδας Της Ινδορνιθας Σε Περιοχες Μακεδονιας Και Θεσσαλιας

“…9) Robeniden 0,0066% μέσα στην τροφή από την ηλικία των 18 ημερών και χια 12 συνεχείς ημέρες (Joyner & Norton, 1972). 10) Aprlnocid 90-120 ppm μέσα στην τροφή συνεχώς (McDougald & Johnson, 1979). 11) Lacalocid (νατριούχο) 0,015, Q,0125, 0,01, 0,0075 και 0,005% μέσα στην τροφή από την ηλικία των 12 ημερών και χια 9 συνεχείς ημέρες (Mitrovic et al, 1979).…”