Florodeoxyglucose imaging: A method to assess the proliferative activity of human cancer in vivo. Comparison with DNA flow cytometry in head and neck tumors

Minn, Heikki; Joensuu, Heikki; Ahonen, Aapo; Klemi, Pekka

doi:10.1002/1097-0142(19880501)61:9<1776::aid-cncr2820610909>3.0.co;2-7

Cited by 224 publications

(84 citation statements)

References 17 publications

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“…An association has been demonstrated between FDG uptake and cellular proliferation and/or tumour growth rate in a number of cancers including head and neck, lung tumours and non-Hodgkin's lymphoma (Minn et al, 1988(Minn et al, , 1997Haberkorn et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

FDG–PET. A possible prognostic factor in head and neck cancer

et al. 2002

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Previous studies have shown that high uptake of 18 F-fluoro-2-deoxy-glucose in head and neck cancer, as determined by the standardized uptake value on positron emission tomography scan, was associated with poor survival. The aim of this study was to confirm the association and to establish whether a high standardized uptake value had prognostic significance. Seventythree consecutive patients with newly diagnosed squamous cell carcinoma of the head and neck underwent a positron emission tomography study before treatment. Age, gender, performance status tumour grade, stage, maximal tumour diameter and standardized uptake value were analyzed for their possible association with survival. The median standardized uptake value for all primary tumours was 7.16 (90% range 2.30 to 18.60). In univariate survival analysis the cumulative survival was decreased as the stage, tumour diameter and standardized uptake value increased. An standardized uptake value of 10 was taken as a cut-off for high and low uptake tumours. When these two groups were compared, an standardized uptake value 410 predicted for significantly worse outcome (P=0.003). Multivariate analysis demonstrated that an standardized uptake value 410 provided prognostic information independent of the tumour stage and diameter (P=0.002). We conclude that high FDG uptake (standardized uptake value410) on positron emission tomography is an important marker for poor outcome in primary squamous cell carcinoma of the head and neck. Standardized uptake value may be useful in distinguishing those tumours with a more aggressive biological nature and hence identifying patients that require intensive treatment protocols including hyperfractionated radiotherapy and/or chemotherapy.

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Section: Discussionmentioning

confidence: 99%

FDG–PET. A possible prognostic factor in head and neck cancer

et al. 2002

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“…6,7 Moreover, recent clinical studies of lung and breast cancers suggest that FDG uptake may have prognostic significance, in that patients with high FDG uptake had a less favorable outcome. 8,9 However, for head and neck carcinomas, the small series available in the literature are of limited usefulness regarding the question of the prognostic value of FDG uptake.…”

Section: A S Is the Case For Many Cancers Indicators Ofmentioning

confidence: 99%

Standardized Uptake Value of 2-[¹⁸F] Fluoro-2-Deoxy-d-Glucose in Predicting Outcome in Head and Neck Carcinomas Treated by Radiotherapy With or Without Chemotherapy

Allal

Dulguerov

Allaoua

et al. 2002

JCO

138

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S t a n d a r d i z e d U p t a k e V a l u e o f 2 -[ 1 8 F ] F l u o r o -2 -D e o x y -D -G l u c o s e i n P r e d i c t i n g O u t c o m e i n H e a d a n d N e c k C a r c i n o m a s T r e a t e d b y R a d i o t h e r a p y W i t h o r W i t h o u t C h e m o t h e r a p yPatients and Methods: We studied 63 patients with carcinomas of the head and neck who had an FDG-PET scan before radical RT. Tumor FDG uptake was measured with the semiquantitative standardized uptake value (SUV). All patients but one were treated with accelerated or hyperfractionated RT schedules. Thirteen patients received concomitant cisplatin-based chemotherapy.Results: In 25 patients who presented with any component of treatment failure, the SUV was significantly higher than in the remaining patients without any such failure. Patients having tumors with high FDG uptake had a significantly lower 3-year local control (55% v 86%, P ‫؍‬ .01) and DFS (42% v 79%, P ‫؍‬ .005) compared with patients having low uptake tumors. In the multivariate analysis, the only factor that retained its significance for DFS was SUV category, whereas T category was of borderline significance. For local control, T category remained a significant factor, whereas a lower local control was observed for tumors with a high SUV compared with those with low SUV.Conclusion: FDG uptake, as measured by the SUV, has potential value in predicting local control and DFS in head and neck carcinomas treated by RT. High FDG uptake may be a useful parameter for identifying patients requiring more aggressive treatment approaches.

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“…It was concentrated in granulomatous tissue and macrophages infiltrating the areas surrounding necrotic tumoral tissue. High accumulation of FDG in the tumour is believed to represent high metabolic activity of the viable tumour cells [43,44].…”

Section: Biological Characteristics Of 18-fdgmentioning

confidence: 99%

Oncological applications of positron emission tomography with fluorine-18 fluorodeoxyglucose

Rigo¹,

Paulus²,

et al. 1996

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Abstract. Positron emission tomography (PET) is now primarily used in oncological indication owing to the successful application of fluorine-18 fluorodeoxyglucose (FDG) in an increasing number of clinical indications at different stages of diagnosis, and for staging and followup. This review first considers the biological characteristics of FDG and then discusses methodological considerations regarding its use. Clinical indications are considered, and the results achieved in respect of various organs and tumour types are reviewed in depth. The review concludes with a brief consideration of the ways in which clinical PET might be improved.

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Florodeoxyglucose imaging: A method to assess the proliferative activity of human cancer in vivo. Comparison with DNA flow cytometry in head and neck tumors

Cited by 224 publications

References 17 publications

FDG–PET. A possible prognostic factor in head and neck cancer

FDG–PET. A possible prognostic factor in head and neck cancer

Standardized Uptake Value of 2-[¹⁸F] Fluoro-2-Deoxy-d-Glucose in Predicting Outcome in Head and Neck Carcinomas Treated by Radiotherapy With or Without Chemotherapy

Oncological applications of positron emission tomography with fluorine-18 fluorodeoxyglucose

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Florodeoxyglucose imaging: A method to assess the proliferative activity of human cancer in vivo. Comparison with DNA flow cytometry in head and neck tumors

Cited by 224 publications

References 17 publications

FDG–PET. A possible prognostic factor in head and neck cancer

FDG–PET. A possible prognostic factor in head and neck cancer

Standardized Uptake Value of 2-[18F] Fluoro-2-Deoxy-d-Glucose in Predicting Outcome in Head and Neck Carcinomas Treated by Radiotherapy With or Without Chemotherapy

Oncological applications of positron emission tomography with fluorine-18 fluorodeoxyglucose

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Standardized Uptake Value of 2-[¹⁸F] Fluoro-2-Deoxy-d-Glucose in Predicting Outcome in Head and Neck Carcinomas Treated by Radiotherapy With or Without Chemotherapy