Flow Cytometry Analysis of Pparα Receptors in Metabolic Syndrome / Studiul Receptorilor Pparα prin Metoda Citometriei în Flux în Sindromul Metabolic

Popa, Elena; Zugun‐Eloae, Florin; Zlei, Mihaela; Jitaru, Daniela; Pintilie, Oana Maria; Coman, Adorata Elena; Traian, Maria Gabriela; Ungureanu, Didona; Carasevici, E

doi:10.2478/rrlm-2014-0036

Cited by 4 publications

(1 citation statement)

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“…Altered endothelial cell function may be an important part of idiopathic PAN, or a consequence of it; in PAN-HVB, viral replication can lead to direct injury to the vascular wall [ 20 ]. Endothelial dysfunction can perpetuate inflammation via cytokine and adhesion molecule production [ 1 , 2 , 19 , 21 ]. In polyarteritis nodosa, the affected vessels become thickened and inflamed due to intimal proliferation.…”

Section: Discussionmentioning

confidence: 99%

The “Viral” Form of Polyarteritis Nodosa (PAN)—A Distinct Entity: A Case Based Review

Pașa,

Popa,

Poroch

et al. 2023

Medicina

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Classic polyarteritis nodosa (PAN) is a vasculitis with systemic manifestations that is characterized by inflammatory and necrotizing lesions affecting medium and small muscular arteries, most frequently at the bifurcation of the vessels. These lesions lead to the formation of microaneurysms, hemorrhaging ruptured aneurysms, thrombosis, and, consequently, ischemia or organ infarction. Background and Objectives: We present a complex clinical case of a patient with a late diagnosis of polyarteritis nodosa with multiorgan involvement. Materials and Methods: The 44-year-old patient, in an urban environment, presented on her own in the emergency room for acute ischemia phenomena and forearm and right-hand compartment syndrome, requiring surgical decompression in the Plastic Surgery Clinic. Results: Significant inflammatory syndrome is noted, alongside severe normocytic hypochromic iron deficiency anemia, nitrogen retention syndrome, hyperkalemia, hepatic syndrome, and immunological disturbances: absence of cANCA, pANCA, anti Scl 70 Ac, antinuclear Ac, and anti dDNA Ac, as well as a low C3 fraction of the plasmatic complement system. The morphological aspect described in the right-hand skin biopsy correlated with the clinical data supports the diagnosis of PAN. Conclusions: The viral form of PAN seems to be individualized as a distinct entity, requiring early, aggressive medication.

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Section: Discussionmentioning

confidence: 99%

The “Viral” Form of Polyarteritis Nodosa (PAN)—A Distinct Entity: A Case Based Review

Pașa,

Popa,

Poroch

et al. 2023

Medicina

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Peroxisome Proliferator-Activated Receptors - Alpha in Chronic Inflammation - Mini-Review

Popa

Zugun‐Eloae

Zlei

et al. 2019

IJPPE

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The pathogeny of the metabolic syndrome (MetS) is not fully elucidated, but a link between visceral obesity and the increase of the proinflammatory response was proven. Atherosclerosis, perceived as a metabolic complication, draws attention to the peroxisome proliferator-activated receptors-alpha (PPARα). PPARα receptors are transcription factors involved in lipid metabolism, inflammation and atheromatosis. Hence, it interferes in the pathogeny of cardiovascular diseases and other chronic diseases too (neurological, psychical, neoplasical). The study of the expression of PPARα and its modulation on different level may be beneficial in the treatment of metabolic syndrome, intervening in the modulation of another proinflammatory factors. PPAR -Mechanism of ActionThe peroxisome proliferator-activated receptors (PPAR), which comprise three PPAR isoform: PPARα, PPARγ and PPARδ (10), act as transcription factors, belonging to the nuclear receptor superfamily [4-6], The mechanism of action of PPARα (Fig. 1) is similar to that of other nuclear receptors (thyroid or that of vitamin D) [7][8][9]11]. The activation of the PPAR receptor determines a change in the structure of the receptor complex, followed by changes in the expression of coded genes. PPAR acts as a ligand-activated transcription factor [7,12].

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Polycystic ovary syndrome (PCOS) – role of chronic inflammation in the expression of dysmetabolic phenotype

Popa¹,

Chiş-Şerban²,

Coman³

2023

Medic.ro

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Flow Cytometry Analysis of Pparα Receptors in Metabolic Syndrome / Studiul Receptorilor Pparα prin Metoda Citometriei în Flux în Sindromul Metabolic

Abstract: Introduction. Metabolic syndrome (MS) is a cluster of distinct metabolic alterations with an increased car-

Cited by 4 publications

References 42 publications

The “Viral” Form of Polyarteritis Nodosa (PAN)—A Distinct Entity: A Case Based Review

The “Viral” Form of Polyarteritis Nodosa (PAN)—A Distinct Entity: A Case Based Review

Peroxisome Proliferator-Activated Receptors - Alpha in Chronic Inflammation - Mini-Review

Polycystic ovary syndrome (PCOS) – role of chronic inflammation in the expression of dysmetabolic phenotype

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