Flow maldistribution represents a problem of particular interest in the engineering field for several thermal systems. In flat plate solar collectors, the thermal efficiency strongly depends on the flow distribution through the riser tubes, where a uniform distribution causes a uniform temperature distribution and therefore a higher efficiency. In this work, a Computational Fluid Dynamics (CFD) numerical analysis has been carried out using the commercial software FLUENT ® , in order to determine the flow distribution, pressure drop and hence the thermal efficiency of a solar collector with distribution flow plates inside the manifolds. The obtained numerical solution for this type of thermal systems has been validated with experimental results available in literature for laminar and turbulent flow. Four distribution plate configurations were analyzed. Results show that using two distribution plates in each of both manifolds improves the flow uniformity up to 40% under the same operating conditions when distribution plates are not used. Besides, it is shown that there exists an increase in the overall pressure drop which is practically negligible for the tilt angles commonly employed in the installation of flat plate solar collectors in Mexico. The use of closed end distribution plates on the dividing and combining manifolds allows the thermal efficiency to become close to the ideal thermal efficiency which is obtained with a uniform flow distribution.