2010
DOI: 10.1039/b9ay00283a
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Flow injection analysis of paracetamol using a biomimetic sensor as a sensitive and selective amperometric detector

Abstract: This work describes the coupling of a biomimetic sensor to a flow injection system for the sensitive determination of paracetamol. The sensor was prepared as previously described in the literature (M. D. P. T. Sotomayor, A. Sigoli, M. R. V. Lanza, A. A. Tanaka and L. T. Kubota, J. Braz. Chem. Soc., 2008, 19, 734) by modifying a glassy carbon electrode surface with a Nafion Ò membrane doped with iron tetrapyridinoporphyrazine (FeTPyPz), a biomimetic catalyst of the P450 enzyme. The performance of the sensor f… Show more

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Cited by 24 publications
(7 citation statements)
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“…In 2010, Oliveira et al [138] developed a biosensor for the determination of paracetamol using a biomimetic sensor coupled to a flow injection analysis FIA system, based on a modified glassy carbon electrode surface with a Nafion ® membrane doped with iron tetrapyridinoporphyrazine (FeTPyPz). On the other hand, anti-inflammatory refers to the property of a substance or treatment that reduces inflammation.…”
Section: Analgesics and Anti-inflammatory Compoundsmentioning
confidence: 99%
“…In 2010, Oliveira et al [138] developed a biosensor for the determination of paracetamol using a biomimetic sensor coupled to a flow injection analysis FIA system, based on a modified glassy carbon electrode surface with a Nafion ® membrane doped with iron tetrapyridinoporphyrazine (FeTPyPz). On the other hand, anti-inflammatory refers to the property of a substance or treatment that reduces inflammation.…”
Section: Analgesics and Anti-inflammatory Compoundsmentioning
confidence: 99%
“…The biomimetic sensor was constructed as previously described [10,11]. First, a solution containing 5 mg mL −1 of the FeTPyPz in DMF was prepared.…”
Section: Electroanalytical Flow Systemmentioning
confidence: 99%
“…In previous papers [10,11] were described the studies carried out to develop an amperometric sensor based on the use of iron tetrapyridinoporphyrazine (FeTPyPz), a biomimetic catalysts of the P450 enzyme, and its coupling and application satisfactory in the paracetamol detection in an FIA system. Due to the excellent characteristics shown by this FIA system using the biomimetic sensor as detector, and being recognized the importance of the degradation of organic compounds by means electrochemistry, this paper intends to demonstrate the viability of the use of sensors highly selective, stable, and durable, in monitoring online and in real-time of the paracetamol electrochemical degradation, as an alternative tool to existing methods for the offline monitoring, that may be time consuming, expensive, pollutants, and often not selective, as are the cases of the chemical oxygen demand and total organic carbon (TOC).…”
Section: Introductionmentioning
confidence: 99%
“…Presence of PCT has been extensively studied in human plasma and urine, but is also being studied in the aquatic environment with reports of up to 10 µg/L in natural water as reported by Kolpin 13. A number of methods have been used for determination of PCT, such as HPLC, flow injection analysis (FIA), and spectrophotometry 14–16. Electrochemical techniques have received more attention in detection of PCT due to the presence of electroactive groups of hydroxyl and acetamido in PCT molecule.…”
Section: Introductionmentioning
confidence: 99%