Flow-mediated vasodilation assay indicates no endothelial dysfunction in hereditary angioedema patients with C1-inhibitor deficiency

Nébenführer, Zsuzsa; Szabó, Erika; Kajdácsi, Erika; Kőhalmi, Kinga Viktória; Karádi, István; Zsáry, András; Cervenak, László

doi:10.1016/j.anai.2018.10.004

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…A similar study by Birjmohun et al, which evaluated the effects of short-and long-term danazol treatment, revealed decreased apoA-I and HDL-cholesterol levels in short-term treated patients in comparison to the baseline measures, while long-term treatment did not adversely affect HDL-cholesterol concentration and apolipoproteins between patients and controls [36]. A more recent study by Nebenführer et al revealed that danazol treated patients suffering from hereditary angioedema with C1 inhibitor deficiency had higher cardiovascular risk, as evaluated by the high body mass index and LDL/HDL ratio, in comparison to healthy controls [238].…”

Section: Hdl In Angioedemamentioning

confidence: 95%

High-Density Lipoprotein (HDL) in Allergy and Skin Diseases: Focus on Immunomodulating Functions

Trakaki

Marsche

2020

Biomedicines

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From an evolutionary perspective, lipoproteins are not only lipid transporters, but they also have important functions in many aspects of immunity. High-density lipoprotein (HDL) particles are the most abundant lipoproteins and the most heterogeneous in terms of their composition, structure, and biological functions. Despite strong evidence that HDL potently influences the activity of several immune cells, the role of HDL in allergies and skin diseases is poorly understood. Alterations in HDL-cholesterol levels have been observed in allergic asthma, allergic rhinitis, atopic dermatitis (eczema), psoriasis, urticaria, and angioedema. HDL-associated apolipoprotein (apo) A-I, apoA-IV, and apoC-III, and lyso-phosphatidylcholines potently suppress immune cell effector responses. Interestingly, recent studies provided evidence that allergies and skin diseases significantly affect HDL composition, metabolism, and function, which, in turn, could have a significant impact on disease progression, but may also affect the risk of cardiovascular disease and infections. Interestingly, not only a loss in function, but also, sometimes, a gain in function of certain HDL properties is observed. The objective of this review article is to summarize the newly identified changes in the metabolism, composition, and function of HDL in allergies and skin diseases. We aim to highlight the possible pathophysiological consequences with a focus on HDL-mediated immunomodulatory activities.

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Section: Hdl In Angioedemamentioning

confidence: 95%

High-Density Lipoprotein (HDL) in Allergy and Skin Diseases: Focus on Immunomodulating Functions

Trakaki

Marsche

2020

Biomedicines

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“…However, the topic is still controversial and Nebenfuhrer et al in a very recent study report no signs of endothelial dysfunction in HAE patients [91]. They performed ultrasound assessment of endothelium-dependent flow-mediated dilation of the brachial artery in 33 C1-INH-HAE patients and in 30 healthy matched controls.…”

Section: Measurement Of Impaired Endothelial Functionmentioning

confidence: 99%

The central role of endothelium in hereditary angioedema due to C1 inhibitor deficiency

Bova

Berra

et al. 2020

International Immunopharmacology

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“…Hereditary angioedema is a rare genetic disorder that is caused by a deficiency or dysfunction of C1 esterase inhibitor (C1 INH), which leads to recurrent episodes of bradykinin‐mediated edema 1 . Triggers for attacks vary by patient, and the consequences can range from pain in the swollen area to life‐threatening airway restriction 2 .…”

Section: Introductionmentioning

confidence: 99%

Transition to lanadelumab‐flyo from three medications for a hereditary angioedema patient with a variant in the SYTL2 gene: A case report

Burns

Lewis²

2021

Clinical Case Reports

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Flow-mediated vasodilation assay indicates no endothelial dysfunction in hereditary angioedema patients with C1-inhibitor deficiency

Cited by 4 publications

References 37 publications

High-Density Lipoprotein (HDL) in Allergy and Skin Diseases: Focus on Immunomodulating Functions

High-Density Lipoprotein (HDL) in Allergy and Skin Diseases: Focus on Immunomodulating Functions

The central role of endothelium in hereditary angioedema due to C1 inhibitor deficiency

Transition to lanadelumab‐flyo from three medications for a hereditary angioedema patient with a variant in the SYTL2 gene: A case report

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