Flow‐through polarographic cell for flow‐injection analysis. Determination of nifedipine in pharmaceutical formulations

Richter, Pablo; Toral, M. Inés; Quiroz, Gabriela; Jaque, Pablo

doi:10.1002/(sici)1098-2728(1997)9:5<255::aid-lra5>3.0.co;2-#

Cited by 14 publications

(10 citation statements)

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“…These analytical techniques include spectrophotometry [37-42], HPLC [43-47], high performance thin layer chromatography [48], micellar electrokinetic chromatography [49], electroanalytical methods [50,51], flow injection analysis [52], and mass spectrometry [53,54]. …”

Section: Introductionmentioning

confidence: 99%

Development and validation of LC/MS/MS method for the simultaneous determination of montelukast, gliclazide, and nifedipine and its application to a pharmacokinetic study

Ezzeldin

Abo-Talib

Tammam

et al. 2014

Chemistry Central Journal

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BackgroundMontelukast is a leukotriene receptor antagonist for treatment of asthma, gliclazide is an oral hypoglycemic antidiabetic agent, and nifedipine is a calcium channel blocker used for treatment of angina pectoris and hypertension. These drugs may be prescribed to patients suffering from these chronic diseases. A survey of the literature reveals that there is no reported method for the simultaneous determination of montelukast, gliclazide, and nifedipine in pharmaceutical preparations or biological fluids.ResultsA simple, sensitive, and rapid method for the simultaneous quantification of montelukast, gliclazide, and nifedipine in human plasma was developed and validated. Montelukast, gliclazide, and nifedipine were resolved using rapid resolution LC/MS/MS Agilent system and SB-C18 (50 × 4.6 mm) 1.8 μm particle size column. The mobile phase consisted of acetonitrile: 0.1% formic acid (84:16). The three drugs were simultaneously extracted from plasma by protein precipitation with acetonitrile using zaferolukast as an internal standard. The method was validated according to FDA guidelines with good reproducibility and linearity of 0.999 and the limits of quantification were 0.11, 0.04, and 0.07 ng/mL for montelukast, gliclazide, and nifedipine, respectively. The accuracies of the three QCs for the three drugs were 99.48% (montelukast), 106.53% (gliclazide), and 108.03% (nifedipine) in human plasma. The validated method was applied to a pharmacokinetic study in human volunteers after oral administration of the three drugs. The applied LC/MS/MS method was shown to be sufficiently sensitive and suitable for pharmacokinetic studies.ConclusionThe LC/MS/MS method was validated and successfully applied for the determination of montelukast, gliclazide, and nifedipine concentrations in human plasma.

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Section: Introductionmentioning

confidence: 99%

Development and validation of LC/MS/MS method for the simultaneous determination of montelukast, gliclazide, and nifedipine and its application to a pharmacokinetic study

Ezzeldin

Abo-Talib

Tammam

et al. 2014

Chemistry Central Journal

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“…Several analytical methods have been described for the assay of nifedipine in pharmaceutical formulations and biological fluids. These methods include spectrophotometry [3,4,5,6], gas chromatography [5,6,7,8,9,10,11,12,13,14], liquid chromatography [6,15,16], high-performance thin-layer chromatography [17], high-performance liquid chromatography [18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41], flow-injection tandem mass spectrometry [42] polarography [43,44], linear-sweep voltammetry [45] and differential-pulse stripping voltammetry [46,47].…”

Section: Introductionmentioning

confidence: 99%

Cathodic adsorptive stripping square-wave voltammetric determination of nifedipine drug in bulk, pharmaceutical formulation and human serum

2003

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Nifedipine is a calcium-channel antagonist drug used in the management of angina pectoris and hypertension through inhibition of calcium influx. A fully validated sensitive cathodic adsorptive stripping square-wave voltammetry procedure was optimized for the determination of the drug at trace levels. The procedure was based on the reduction of the nitrophenyl group after the interfacial accumulation of the drug onto a hanging mercury drop electrode in Britton-Robinson buffer of pH 11.0. The optimal conditions of the procedure were found to be: accumulation potential=-0.9 V vs. Ag/AgCl/KCl(s)), accumulation time=30 s, scan increment=10 mV, pulse amplitude=50 mV and frequency=120 Hz. Under these conditions, a well-defined peak was obtained; its peak current showed a linear dependence on drug concentration in the range of 2x10(-9)-2x10(-7) mol L(-1) bulk nifedipine. The mean recoveries based on eight replicate measurements for 1x10(-8) and 5x10(-8) mol L(-1) bulk nifedipine solutions were 98.46+/-0.86% and 98.23+/-0.92%, respectively. A detection limit of 3.42x10(-10) mol L(-1) bulk nifedipine was achieved. The procedure was successfully applied for assay of the drug in tablets and spiked human serum with mean recoveries of 101.95+/-1.42% and 98.70+/-0.63%, respectively. The limit of detection of the drug in spiked human serum was found to be 3.90x10(-10) mol L(-1).

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“…These include high performance thin layer chromatography, 4 high performance liquid chromatography, 5 gas chromatography coupled with mass spectrometry, 6 micellar electrokinetic chromatography, 7 flow injection analysis, 8 electroanalytical methods 9 and UV spectrophotometry. 10 The estimation of nifedipine in single and combined dosage forms has been made using second order 11 and first order 12 derivative spectra, respectively.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Rahman¹,

Azmi²

2006

ScienceAsia

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A validated spectrophotometric method has been described for the assay of nifedipine in bulk and commercial dosage forms. The method is based on the oxidation of drug with Fe(III) at pH 1.42. The reduced Fe(II) subsequently reacts with 1,10-phenanthroline to produce a red colored tris(1,10-phenanthroline) iron(II) complex, which absorbs maximally at 505 nm. Beer's law is obeyed in the concentration range 0.5 -14.0 µg mL -1 with molar absorptivity and Sandell' s sensitivity of 2.805×10 4 L mol -1 cm -1 and 0.012 µg cm -2 per 0.001 absorbance unit, respectively. The various experimental parameters were optimized. The method has been successfully applied for the quantitation of the drug in commercial dosage forms. The results of analysis were statistically compared with those of a reference method showing acceptable recovery and precision. The experimental true bias of all samples based on recovery experiments were within ± 2 %.

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Flow‐through polarographic cell for flow‐injection analysis. Determination of nifedipine in pharmaceutical formulations

Abstract: A simple design of a polarographic flow-through cell is proposed in which

Cited by 14 publications

References 15 publications

Development and validation of LC/MS/MS method for the simultaneous determination of montelukast, gliclazide, and nifedipine and its application to a pharmacokinetic study

Development and validation of LC/MS/MS method for the simultaneous determination of montelukast, gliclazide, and nifedipine and its application to a pharmacokinetic study

Cathodic adsorptive stripping square-wave voltammetric determination of nifedipine drug in bulk, pharmaceutical formulation and human serum

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